European Journal of Chemistry

Synthesis, characterization and acute toxicity of new Schiff base derived from L-arginine and vanillin

Article Sidebar

PDF
Published: Sep 30, 2016
DOI: https://doi.org/10.5155/eurjchem.7.3.280-282.1431
Keywords:
Vanillin, Schiff base, L-Arginine, Amino acid, Acute toxicity, Median lethal dose
Section
Research Article
Issue
Vol. 7 No. 3 (2016): September 2016
Dates
Received 2016-03-25
Accepted 2016-04-29
Published 2016-09-30


Main Article Content

Wasfi Aboud Al-Masoudi
Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, University of Basrah, Basrah, 61001, Iraq
Mohammed Ali Al-Diwan
Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, University of Basrah, Basrah, 61001, Iraq
Orass Saad Khayoon
Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, University of Basrah, Basrah, 61001, Iraq

Abstract

Condensation of L-arginine with 4-hydroxy-3-methoxy benzaldehyde (vanillin) yielded a novel Schiff base derivative of arginine in good yield. This new Schiff base was characterized by elemental analysis, IR and 1H NMR spectroscopy. The toxicity of the compound was also assayed via the determination of their LD50 value by using Dixon method. Studied compound was found to have an LD50 of 718.6 mg/kg of body weight.


icon graph This Abstract was viewed 1957 times | icon graph Article PDF downloaded 992 times

How to Cite
(1)
Al-Masoudi, W. A.; Al-Diwan, M. A.; Khayoon, O. S. Synthesis, Characterization and Acute Toxicity of New Schiff Base Derived from L-Arginine and Vanillin. Eur. J. Chem. 2016, 7, 280-282.

Article Details

Share
Links for Article


Crossref - Scopus - Google - European PMC
Crossref
Scopus
Google Scholar
Europe PMC
References

[1]. Tapiero, H.; Mathe, G.; Couvreur, P.; Tew, K. D. Biomed. Pharmacother. 2002, 56(9), 439-445.
http://dx.doi.org/10.1016/S0753-3322(02)00284-6

[2]. Stechmiller, J. K.; Childress, B.; Cowan, L. Nutr. Clin. Prac. 2005, 20(1), 52-61.
http://dx.doi.org/10.1177/011542650502000152

[3]. Witte, M. B.; Barbul, A. Wound Repair Regen. 2003, 11(6), 419-423.
http://dx.doi.org/10.1046/j.1524-475X.2003.11605.x

[4]. Wascher, T. C.; Graier, W. F.; Dittrich, P.; Hussain, M. A.; Bahadori, B.; Wallner, S.; Toplak, H. Eur. J. Clin. Invest. 1997, 27(8), 690-695.
http://dx.doi.org/10.1046/j.1365-2362.1997.1730718.x

[5]. Lubec, B.; Hayn, M.; Kitzmuller, E.; Vierhapper, H.; Lubec, G. Free Radic. Biol. Med. 1997, 22(1-2), 355-357.
http://dx.doi.org/10.1016/S0891-5849(96)00386-3

[6]. Campbell, B. I.; La-Bounty, P. M.; Roberts, M. J. Int. Soc. Sports. Nutr. 2004, 1(2), 35-38.
http://dx.doi.org/10.1186/1550-2783-1-2-35

[7]. Collier, S. R.; Casey, D. P.; Kanaley, J. A. Growth Horm. IGF. Res. 2005, 15(2), 136-139.
http://dx.doi.org/10.1016/j.ghir.2004.12.004

[8]. Boger, R. H.; Bode-Boger, S. M.; Mugge, A.; Kienke, S.; Brandes, R.; Dwenger, A.; Frölich, J. C. Atherosclerosis 1995, 117(2), 273-284.
http://dx.doi.org/10.1016/0021-9150(95)05582-H

[9]. Grasemann, H.; Kurtz, F.; Ratjen, F. Am. J. Respir. Crit. Care Med. 2006, 174(2), 208-212.
http://dx.doi.org/10.1164/rccm.200509-1439OC

[10]. Angeli, G.; Turibio, L.; Daniel, F.; Marcelo, L. Rev. Bras. Med. Esporte. 2007, 13(2), 112-115.
http://dx.doi.org/10.1590/S1517-86922007000200012

[11]. Sari, N.; Gurkan, P. Z. Naturforsch. B 2004, 59, 692-698.

[12]. Walton, N. J.; Mayer, M. J.; Narbad, A. Phytochemistry 2003, 63, 505-515.
http://dx.doi.org/10.1016/S0031-9422(03)00149-3

[13]. Burrite, J.; Graf, M.; Lambelet, P.; Loliger, J. J. Sci. Food Agric. 1989, 48, 49-56.
http://dx.doi.org/10.1002/jsfa.2740480107

[14]. Kamat, J. P.; Ghosh, A.; Devasagayam, T. P. A. Mol. Cell. Biochem. 2000, 209, 47-53.
http://dx.doi.org/10.1023/A:1007048313556

[15]. Dixon, W. J. Ann. Res. Pharmacol. Toxicol. 1980, 20, 441-462.
http://dx.doi.org/10.1146/annurev.pa.20.040180.002301

Supporting Agencies

Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, Al-Basrah University, Iraq
Most read articles by the same author(s)
TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2025 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).