European Journal of Chemistry

Synthesis, characterization and acute toxicity of new Schiff base derived from L-arginine and vanillin

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Published: Sep 30, 2016
DOI: https://doi.org/10.5155/eurjchem.7.3.280-282.1431
Keywords:
Vanillin, Schiff base, L-Arginine, Amino acid, Acute toxicity, Median lethal dose
Section
Research Article
Issue
Vol. 7 No. 3 (2016): September 2016
Dates
Received 2016-03-25
Accepted 2016-04-29
Published 2016-09-30


Main Article Content

Wasfi Aboud Al-Masoudi
Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, University of Basrah, Basrah, 61001, Iraq
Mohammed Ali Al-Diwan
Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, University of Basrah, Basrah, 61001, Iraq
Orass Saad Khayoon
Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, University of Basrah, Basrah, 61001, Iraq

Abstract

Condensation of L-arginine with 4-hydroxy-3-methoxy benzaldehyde (vanillin) yielded a novel Schiff base derivative of arginine in good yield. This new Schiff base was characterized by elemental analysis, IR and 1H NMR spectroscopy. The toxicity of the compound was also assayed via the determination of their LD50 value by using Dixon method. Studied compound was found to have an LD50 of 718.6 mg/kg of body weight.


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Al-Masoudi, W. A.; Al-Diwan, M. A.; Khayoon, O. S. Synthesis, Characterization and Acute Toxicity of New Schiff Base Derived from L-Arginine and Vanillin. Eur. J. Chem. 2016, 7, 280-282.

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Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, Al-Basrah University, Iraq
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