European Journal of Chemistry 2014, 5(1), 111-121 | doi: https://doi.org/10.5155/eurjchem.5.1.111-121.860 | Get rights and content






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Synthesis, reactions, antioxidant and anticancer evaluation of some novel coumarin derivatives using ethyl 2-(2-oxo-4-phenyl-2H-chromen-7-yloxy) acetate as a starting material


Ahmed Hamdy Halawa (1) , Ahmed Abd El-Hameed Hassan (2,*) , Mohamed Ahmed El-Nassag (3) , Mahmoud Mohamed Abd El-All (4) , GehadAbd El-Raheem Abd El-Jaleel (5) , Essam Mohamed Eliwa (6) , Ahmed Hammam Bedair (7)

(1) Chemistry Department, Faculty of Science, Al-Azhar University, 11884, Nasr City, Cairo, Egypt
(2) Chemistry Department, Faculty of Medicine, Jazan Universit y, 82621, Jazan, Saudi Arabia
(3) Chemistry Department, Faculty of Science, Al-Azhar University, 11884, Nasr City, Cairo, Egypt
(4) Chemistry Department, Faculty of Science and Art, Al-Baha University, 1988, Al-Baha, Saudi Arabia
(5) Pharmacology Department, National Research Center, 12622, Dokki, Cairo, Egypt
(6) Chemistry Department, Faculty of Science, Al-Azhar University, 11884, Nasr City, Cairo, Egypt
(7) Chemistry Department, Faculty of Science, Al-Azhar University, 11884, Nasr City, Cairo, Egypt
(*) Corresponding Author

Received: 15 Jun 2013 | Accepted: 15 Sep 2013 | Published: 31 Mar 2014 | Issue Date: March 2014

Abstract


We report on the synthesis of new coumarin derivatives coupled with heterocyclic and bifunctionalized moieties at position 7. The proposed structures were confirmed by correct elemental analysis and spectral data (IR, MS, 1H NMR and 13C NMR). Some selected derivatives were also screened for their antioxidant and anticancer activities. The results indicated that 7-{[6-(4-nitrophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl]methoxy}-4-phenyl-H-chromen-2-one has the highest antioxidant and anticancer activity in tested compounds.


Keywords


Triazole; Oxadiazole; Cytotoxicity; Benzoimidazole; Antioxidant activity; Coumarinacetohydrazide

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DOI: 10.5155/eurjchem.5.1.111-121.860

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Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt

Citations

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How to cite


Halawa, A.; Hassan, A.; El-Nassag, M.; Abd El-All, M.; Abd El-Jaleel, G.; Eliwa, E.; Bedair, A. Eur. J. Chem. 2014, 5(1), 111-121. doi:10.5155/eurjchem.5.1.111-121.860
Halawa, A.; Hassan, A.; El-Nassag, M.; Abd El-All, M.; Abd El-Jaleel, G.; Eliwa, E.; Bedair, A. Synthesis, reactions, antioxidant and anticancer evaluation of some novel coumarin derivatives using ethyl 2-(2-oxo-4-phenyl-2H-chromen-7-yloxy) acetate as a starting material. Eur. J. Chem. 2014, 5(1), 111-121. doi:10.5155/eurjchem.5.1.111-121.860
Halawa, A., Hassan, A., El-Nassag, M., Abd El-All, M., Abd El-Jaleel, G., Eliwa, E., & Bedair, A. (2014). Synthesis, reactions, antioxidant and anticancer evaluation of some novel coumarin derivatives using ethyl 2-(2-oxo-4-phenyl-2H-chromen-7-yloxy) acetate as a starting material. European Journal of Chemistry, 5(1), 111-121. doi:10.5155/eurjchem.5.1.111-121.860
Halawa, Ahmed, Ahmed Abd El-Hameed Hassan, Mohamed Ahmed El-Nassag, Mahmoud Mohamed Abd El-All, GehadAbd El-Raheem Abd El-Jaleel, Essam Mohamed Eliwa, & Ahmed Hammam Bedair. "Synthesis, reactions, antioxidant and anticancer evaluation of some novel coumarin derivatives using ethyl 2-(2-oxo-4-phenyl-2H-chromen-7-yloxy) acetate as a starting material." European Journal of Chemistry [Online], 5.1 (2014): 111-121. Web. 28 Nov. 2020
Halawa, Ahmed, Hassan, Ahmed, El-Nassag, Mohamed, Abd El-All, Mahmoud, Abd El-Jaleel, GehadAbd, Eliwa, Essam, AND Bedair, Ahmed. "Synthesis, reactions, antioxidant and anticancer evaluation of some novel coumarin derivatives using ethyl 2-(2-oxo-4-phenyl-2H-chromen-7-yloxy) acetate as a starting material" European Journal of Chemistry [Online], Volume 5 Number 1 (31 March 2014)

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DOI Link: https://doi.org/10.5155/eurjchem.5.1.111-121.860

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