European Journal of Chemistry 2014, 5(2), 272-276 | doi: https://doi.org/10.5155/eurjchem.5.2.272-276.1005 | Get rights and content






  OPEN ACCESS | PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS

Application of π receptors to the spectrophotometric determination of naftidrofuryl oxalate in pure form and its pharmaceutical preparation


Kareem Mahmoud Younes (1,*) , Mai Adel Basha (2) , Maissa Yacoub Salem (3)

(1) Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, ET-11562, Cairo, Egypt
(2) Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, ET-11562, Cairo, Egypt
(3) Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, ET-11562, Cairo, Egypt
(*) Corresponding Author

Received: 22 Dec 2013 | Accepted: 04 Jan 2014 | Published: 30 Jun 2014 | Issue Date: June 2014

Abstract


Three different spectrophotometric methods are developed for the determination of naftidrofuryl oxalate (NAF) in pure form and its pharmaceutical preparation. The methods are based on charge transfer complexation reactions of NAF as n-electron donor with either p-chloranilic acid (PCA) or 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) or tetracyano ethylene (TCNE) as π-receptors to give highly colored anion radicals species. The colored products were quantified spectrophotometrically at 515, 588 and 396 nm in PCA, DDQ and TCNE methods, respectively. Under the optimized experimental conditions, Beer's law is obeyed over the concentration ranges of 75.0-300.0, 25.0-150.0 and 15.0- 50.0 μg/mL NAF for PCA, DDQ and TCNE methods, respectively. The proposed methods were applied successfully to the determination of NAF in pure form and its commercial tablets with good accuracy and precision. Statistical comparison of the results was performed using Student's t-test and F-ratio at 95% confidence level, showing that there is no significant difference between the reference and the proposed methods with regard to accuracy and precision. Further, the validity of the proposed methods was confirmed by standard addition technique.


Keywords


Chloranilic acid; Tetracyanoethylene; Naftidrofuryl oxalate; Pharmaceutical preparation; Charge transfer complexation; 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone

Full Text:

PDF /    /


DOI: 10.5155/eurjchem.5.2.272-276.1005

Links for Article


| | | | | | |

| | | | | | |

Related Articles




Article Metrics

This Abstract was viewed 659 times | PDF Article downloaded 420 times

Funding information


Minapharm Pharmaceutical Industries Company, Egypt

Citations

/


[1]. Fawzia A. Ibrahim, Amina M. Elbrashy, Jenny Jeehan M. Nasr, Mostafa M. Badr El-Dien
Application of π acceptors to the spectrophotometric and spectrofluorimetric determination of vincamine and naftidrofuryl oxalate in their pharmaceutical preparations
Luminescence  32(4), 555, 2017
DOI: 10.1002/bio.3221
/


References

[1]. Reynolds, J. E. F. (Ed.), Martindale: The Extra Pharmacopoeia, 35th edition, the Pharmaceutical Press, London, 2007.

[2]. British Pharmacopoeia-2009, Her Majesty Stationary Office, London, Vol: I, 2009.

[3]. Brodie, R. R.; Chasseaud, L. F.; Taylor, T.; Hunter, J. O.; Ciclitira, P. J. J. Chromatogr. 1979, 164, 534-540.
http://dx.doi.org/10.1016/S0378-4347(00)81559-5

[4]. Waaler, P. J.; Müller, B. W. Inter. J. Pharm. 1992, 1(3), 223-227.
http://dx.doi.org/10.1016/0378-5173(92)90246-X

[5]. Sabry, S. M.; Belal, T. S.; Barary, M. H; Ibrahim, M. E. J. Drug Test Anal. 2012, 5(6), 500-508.
http://dx.doi.org/10.1002/dta.421

[6]. Stehlik, P.; Houbova, H. Cesk. Farm. 1990, 39(9), 394-399.

[7]. Walmsley, L. M.; Wilkinson, P. A.; Brodie, R. R.; Chasseaud, L. F. J. Chromatogr. 1982, 338(2), 433-437.

[8]. Segura, C. A.; Cruces, B. C.; Canabate, D. B.; Fernandez, S. J. F.; Fernandez, G. A. Anal. Chim. Acta 2000, 417, 19-30.
http://dx.doi.org/10.1016/S0003-2670(00)00917-X

[9]. Munoz, P. A.; Espinosa, M. A.; Murillo, P. J. A.; Alanon, M. A.; Fernandez, L. P. Analyst 1998, 123, 2285-2290.
http://dx.doi.org/10.1039/a804632h

[10]. Ionescu, M. S.; Badea, V.; Baiulescu, G.; Cosofret, V. V. Talanta 1986, 33, 101-103.
http://dx.doi.org/10.1016/0039-9140(86)80021-2

[11]. Abbas, S. S.; Zaazaa, H. E.; El-Ghobashy, M. R.;Fayez, Y. M.; Fattah, S. A. Port. Electr. Acta 2012, 30(3), 177-188.
http://dx.doi.org/10.4152/pea.201203177

[12]. Fernandez, S. J. F.; Segura, C. A.; Cruces, B. C.;Fernandez, G. Anal. Chim. Acta 2002, 462, 217-224.
http://dx.doi.org/10.1016/S0003-2670(02)00348-3

[13]. Suzy, M. S.; Tarek, S. B.; Magda, H. B.; Mohammed, E. A. I. J. Biomed. Sci. 2009, 5(3), 283-292.

[14]. Ayad, M.; Abdellatef, H.; Hosny, M.; Sharaf, Y. Asian J Pharm. Clinic. Res. 2013, 6(1), 92-102.

[15]. Belal, T. S.; Barary, M. H.; Sabry, S. M.; Abdellatef, M. E. Food Drug Anal. 2009, 17(6), 415-423.

[16]. Abbas, S. S.; Zaazaa, H. E.; El-Ghobashy, M. R.; Fayez, Y. M.; Fattah, S. A. Anal. Chem., An Indian J. 2012, 11(11,12), 329-334.

[17]. Abbas, S. S.; Zaazaa, H. E.; El-Ghobashy, M. R.; Fayez, Y. M.; Fattah, S. A. Anal. Chem., An Indian J. 2009, 8(4), 613-620.

How to cite


Younes, K.; Basha, M.; Salem, M. Eur. J. Chem. 2014, 5(2), 272-276. doi:10.5155/eurjchem.5.2.272-276.1005
Younes, K.; Basha, M.; Salem, M. Application of π receptors to the spectrophotometric determination of naftidrofuryl oxalate in pure form and its pharmaceutical preparation. Eur. J. Chem. 2014, 5(2), 272-276. doi:10.5155/eurjchem.5.2.272-276.1005
Younes, K., Basha, M., & Salem, M. (2014). Application of π receptors to the spectrophotometric determination of naftidrofuryl oxalate in pure form and its pharmaceutical preparation. European Journal of Chemistry, 5(2), 272-276. doi:10.5155/eurjchem.5.2.272-276.1005
Younes, Kareem, Mai Adel Basha, & Maissa Yacoub Salem. "Application of π receptors to the spectrophotometric determination of naftidrofuryl oxalate in pure form and its pharmaceutical preparation." European Journal of Chemistry [Online], 5.2 (2014): 272-276. Web. 9 Aug. 2020
Younes, Kareem, Basha, Mai, AND Salem, Maissa. "Application of π receptors to the spectrophotometric determination of naftidrofuryl oxalate in pure form and its pharmaceutical preparation" European Journal of Chemistry [Online], Volume 5 Number 2 (30 June 2014)

The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item


DOI Link: https://doi.org/10.5155/eurjchem.5.2.272-276.1005

| | | | | | |

| | | | | |

Save to Zotero Save to Mendeley



European Journal of Chemistry 2014, 5(2), 272-276 | doi: https://doi.org/10.5155/eurjchem.5.2.272-276.1005 | Get rights and content

Refbacks

  • There are currently no refbacks.




Copyright (c)




© Copyright 2010 - 2020  Atlanta Publishing House LLC All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2010-2020 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.

hatay escort hatay escort corlu escort corum escort burgaz escort giresun escort aydin escort ordu escort erzincan escort hatay escort sivas escort rize escort edirne escort aksaray escort kibris escort isparta escort erzurum escort tekirdag escort usak escort urfa escort kastamonu escort kibris escort manisa escort giresun escort urfa escort nevsehir escort sivas escort yalova escort ordu escort hatay escort yalova escort amasya escort kayseri escort ordu escort maras escort canakkale escort yalova escort balikesir escort manisa escort urfa escort mugla escort trabzon escort bolu escort corlu escort diyarbakir escort isparta escort kutahya escort elazig escort erzurum escort sakarya escort afyon escort kutahya escort konya escort agri escort cesme escort sinop escort sivas escort konya escort kibris escort adapazari escort luleburgaz escort adana escort kibris escort rize escort sakarya escort alanya escort isparta escort burdur escort konya escort bitlis escort canakkale escort sivas escort amasya escort mus escort aydin escort van escort yalova escort kastamonu escort mardin escort bolu escort afyon escort sakarya escort isparta escort tokat escort trakya escort bayburt escort urfa escort mardin escort