European Journal of Chemistry 2014, 5(2), 272-276. doi:10.5155/eurjchem.5.2.272-276.1005

Application of π receptors to the spectrophotometric determination of naftidrofuryl oxalate in pure form and its pharmaceutical preparation


Kareem Mahmoud Younes (1,*) , Mai Adel Basha (2) , Maissa Yacoub Salem (3)

(1) Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, ET-11562, Cairo, Egypt
(2) Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, ET-11562, Cairo, Egypt
(3) Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, ET-11562, Cairo, Egypt
(*) Corresponding Author

Received: 22 Dec 2013, Accepted: 04 Jan 2014, Published: 30 Jun 2014

Abstract


Three different spectrophotometric methods are developed for the determination of naftidrofuryl oxalate (NAF) in pure form and its pharmaceutical preparation. The methods are based on charge transfer complexation reactions of NAF as n-electron donor with either p-chloranilic acid (PCA) or 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) or tetracyano ethylene (TCNE) as π-receptors to give highly colored anion radicals species. The colored products were quantified spectrophotometrically at 515, 588 and 396 nm in PCA, DDQ and TCNE methods, respectively. Under the optimized experimental conditions, Beer's law is obeyed over the concentration ranges of 75.0-300.0, 25.0-150.0 and 15.0- 50.0 μg/mL NAF for PCA, DDQ and TCNE methods, respectively. The proposed methods were applied successfully to the determination of NAF in pure form and its commercial tablets with good accuracy and precision. Statistical comparison of the results was performed using Student's t-test and F-ratio at 95% confidence level, showing that there is no significant difference between the reference and the proposed methods with regard to accuracy and precision. Further, the validity of the proposed methods was confirmed by standard addition technique.


Keywords


Chloranilic acid; Tetracyanoethylene; Naftidrofuryl oxalate; Pharmaceutical preparation; Charge transfer complexation; 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone

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DOI: 10.5155/eurjchem.5.2.272-276.1005

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[1]. Fawzia A. Ibrahim, Amina M. Elbrashy, Jenny Jeehan M. Nasr, Mostafa M. Badr El-Dien
Application of π acceptors to the spectrophotometric and spectrofluorimetric determination of vincamine and naftidrofuryl oxalate in their pharmaceutical preparations
Luminescence  32(4), 555, 2017
DOI: 10.1002/bio.3221
/


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How to cite


Younes, K.; Basha, M.; Salem, M. Eur. J. Chem. 2014, 5(2), 272-276. doi:10.5155/eurjchem.5.2.272-276.1005
Younes, K.; Basha, M.; Salem, M. Application of π receptors to the spectrophotometric determination of naftidrofuryl oxalate in pure form and its pharmaceutical preparation. Eur. J. Chem. 2014, 5(2), 272-276. doi:10.5155/eurjchem.5.2.272-276.1005
Younes, K., Basha, M., & Salem, M. (2014). Application of π receptors to the spectrophotometric determination of naftidrofuryl oxalate in pure form and its pharmaceutical preparation. European Journal of Chemistry, 5(2), 272-276. doi:10.5155/eurjchem.5.2.272-276.1005
Younes, Kareem, Mai Adel Basha, & Maissa Yacoub Salem. "Application of π receptors to the spectrophotometric determination of naftidrofuryl oxalate in pure form and its pharmaceutical preparation." European Journal of Chemistry [Online], 5.2 (2014): 272-276. Web. 22 Sep. 2019
Younes, Kareem, Basha, Mai, AND Salem, Maissa. "Application of π receptors to the spectrophotometric determination of naftidrofuryl oxalate in pure form and its pharmaceutical preparation" European Journal of Chemistry [Online], Volume 5 Number 2 (30 June 2014)

DOI Link: https://doi.org/10.5155/eurjchem.5.2.272-276.1005

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