

Solvatochromic absorption and fluorescence studies of adenine, thymine and uracil thio-derived acyclonucleosides
Hassan Hasan Hammud (1)




(1) Department of Chemistry, Faculty of Science, King Faisal University, Al-Ahsa, 31982, Saudi Arabia
(2) Department of Chemistry, Faculty of Science, Beirut Arab University, Debbieh, 11-5020, Lebanon
(3) Department of Chemistry, Faculty of Science, Beirut Arab University, Debbieh, 11-5020, Lebanon
(4) Department of Chemistry, Faculty of Arts and Sciences, American University of Beirut, Beirut, 11-0236, Lebanon
(*) Corresponding Author
Received: 09 Jun 2015 | Revised: 08 Jul 2015 | Accepted: 15 Jul 2015 | Published: 30 Sep 2015 | Issue Date: September 2015
Abstract
Adenine, thymine and uracil thio-derived acyclonucleosides were synthesized and characterized by UV-Vis, FT-IR, 1H and 13C NMR spectroscopic techniques. The photophysical properties of the derivatives were evaluated in solvents with diverse polarities and at various pH values. The solvent dependent absorbance and emission spectral shifts were analysed using physical parameters of the selected solvents. The regression and correlation coefficients were calculated using multiple regression techniques. The fitting coefficients gave an estimate of the contribution of each interaction to the total spectral shift in various solutions. Multiple linear regression studies, Kamlet-Taft equation and stokes shift correlation with orientation polarizability provide valuable information concerning spectroscopic characteristics of the studied molecules.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.6.3.325-336.1282
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Funding information
Kamal Shair Central Research Science Laboratory (KAS-CRSL); Lebanese National Research Council (LNCSR) and the University Research Board (URB) at the American University of Beirut, Lebanon
Citations
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