European Journal of Chemistry

Determination of binary mixture of ibuprofen and famotidine by different spectrophotometric methods

Main Article Content

Ahmed Aqeel Al-Shibly
Hany Hunter Monir
Mohamed Refaat El-Ghobashy
Sawsan Mohamed Amer


Four simple and specific spectrophotometric methods were developed and validated for the simultaneous determination of binary mixture of ibuprofen and famotidine, using unified regression equation. The proposed spectrophotometric procedures including, derivative ratio, ratio subtraction, dual wavelength and mean centering of ratio spectra do not require any separation steps. Accuracy, precision and linearity ranges of the proposed methods were determined and the specificity was assessed by analysing synthetic mixtures of both drugs. The methods were applied to a pharmaceutical formulation and the results obtained showed that there is no significant difference between the proposed methods and the reported one regarding both accuracy and precision.

icon graph This Abstract was viewed 1358 times | icon graph Article PDF downloaded 663 times

How to Cite
Al-Shibly, A. A.; Monir, H. H.; El-Ghobashy, M. R.; Amer, S. M. Determination of Binary Mixture of Ibuprofen and Famotidine by Different Spectrophotometric Methods. Eur. J. Chem. 2016, 7, 161-165.

Article Details

Crossref - Scopus - Google - European PMC

[1]. O'Neil, M. J. The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. 13th Edition, Whitehouse Station, NJ: Merck and Co., Inc., 2001.

[2]. Katzung, B. G.; Furst, D. E. Basic and clinical pharmacology, 7th ed., Appliton and Lang Stamford, Connecticut, 1998.

[3]. Elzanfaly, E. S.; H. E. Zaazaa.; Soudi, A. T.; Salem, M. Y. Acta Chim. Slov. 2015, 62, 45-51.

[4]. Brophy, G. M.; Bidwell, K. L. Neurocrit. Care 2010, 13, 176-181.

[5]. Kumar, S. A.; Debnath, M.; Rao, J. V. L. N. S.; Sankar, D. G. Int. J. Pharm. Sci. Res. 2014, 5(9), 3829-3839.

[6]. Gracy, S.; Kumar, S. A.; Debnath, M.; Rao, J. V. L. N. S.; Sankar, D. G.; Mounika, T. A. Int. J. Pharm. Sci. Res. 2014, 5(4), 300-305.

[7]. Sekhar, V. R.; Reddy, Y. P.; Ramalingam, P.; Theja, D. H. Der. Phar. Sinica 2013, 4(2), 160-170.

[8]. Shah, D. A.; Suthar, D. J.; Baldania, S. L.; Chhalotiya, U. K.; Bhatt, K. K. ISRN Anal. Chem. 2012, 2012, Article ID 674392, 1-5.

[9]. Nyola, N.; Jeyabalan G. S. J. Appl. Pharm. Sci. 2012, 2(5), 79-83.

[10]. Ahirrao, V. K.; Pawar, R. P. Res. J. Pharm. Sci. 2013, 2(4), 1-9.

[11]. Krishnaveni, G.; Sathyannarayana, P. V. V. Int. J. Pharma Bio Sci. 2013, 4(3), 655-662.

[12]. Algobahi, K. M.; Younis, Y. M. H. Int. J. Res. Pharm. Sci. 2012, 2(3), 69-80.

[13]. Prasad, P. R.; Bhuveneswari, K.; Murarilal, M.; Rajani, K. Der Pharmacia Let. 2015, 7(1), 232-237.

[14]. Wani, Y. B.; Patil, D. D. Int. J. Pharm. Pharm. Sci. 2013, 5(3), 358-363.

[15]. Lotfy, H. M.; Hegazy, M. A. M. Spectrochim. Acta A 2013, 113, 107-114.

[16]. Fayez, Y. M. Spectrochim. Acta A 2014, 132, 446-451.

[17]. Lotfy, H. M.; Hegazy, M. A. M.; Abdel-Gawad, S. A. N. Eur. J. Chem. 2013, 4(4), 414-421.

[18]. Validation of Analytical Procedures: Text and Methodology Q2 (R1), ICH, 1997.

[19]. Abdel-Aleem, E. A.; Hegazy, M. A.; Sayed, N. W.; Abdelkawy, M.; Abdelfatah, R. M. Spectrochim. Acta A 2015, 136, 707-713.

[20]. Zaazaa, H. E.; Elzanfaly, E. S.; Soudi, A. T.; Salem, M. Y. Spectrochim. Acta A 2015, 143, 251-255.

Supporting Agencies

Most read articles by the same author(s)

Most read articles by the same author(s)


Dimensions - Altmetric - scite_ - PlumX

Downloads and views


Download data is not yet available.


Metrics Loading ...
License Terms

License Terms


Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License ( By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License ( are administered by Atlanta Publishing House LLC (European Journal of Chemistry).