European Journal of Chemistry 2016, 7(2), 161-165. doi:10.5155/eurjchem.7.2.161-165.1407

Determination of binary mixture of ibuprofen and famotidine by different spectrophotometric methods


Ahmed Aqeel Al-Shibly (1,*) , Hany Hunter Monir (2) , Mohamed Refaat El-Ghobashy (3) , Sawsan Mohamed Amer (4)

(1) Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, 11562, Cairo, Egypt
(2) Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, 11562, Cairo, Egypt
(3) Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, 11562, Cairo, Egypt
(4) Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, 11562, Cairo, Egypt
(*) Corresponding Author

Received: 07 Feb 2016, Accepted: 12 Mar 2016, Published: 30 Jun 2016

Abstract


Four simple and specific spectrophotometric methods were developed and validated for the simultaneous determination of binary mixture of ibuprofen and famotidine, using unified regression equation. The proposed spectrophotometric procedures including, derivative ratio, ratio subtraction, dual wavelength and mean centering of ratio spectra do not require any separation steps. Accuracy, precision and linearity ranges of the proposed methods were determined and the specificity was assessed by analysing synthetic mixtures of both drugs. The methods were applied to a pharmaceutical formulation and the results obtained showed that there is no significant difference between the proposed methods and the reported one regarding both accuracy and precision.


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DOI: 10.5155/eurjchem.7.2.161-165.1407

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How to cite


Al-Shibly, A.; Monir, H.; El-Ghobashy, M.; Amer, S. Eur. J. Chem. 2016, 7(2), 161-165. doi:10.5155/eurjchem.7.2.161-165.1407
Al-Shibly, A.; Monir, H.; El-Ghobashy, M.; Amer, S. Determination of binary mixture of ibuprofen and famotidine by different spectrophotometric methods. Eur. J. Chem. 2016, 7(2), 161-165. doi:10.5155/eurjchem.7.2.161-165.1407
Al-Shibly, A., Monir, H., El-Ghobashy, M., & Amer, S. (2016). Determination of binary mixture of ibuprofen and famotidine by different spectrophotometric methods. European Journal of Chemistry, 7(2), 161-165. doi:10.5155/eurjchem.7.2.161-165.1407
Al-Shibly, Ahmed, Hany Hunter Monir, Mohamed Refaat El-Ghobashy, & Sawsan Mohamed Amer. "Determination of binary mixture of ibuprofen and famotidine by different spectrophotometric methods." European Journal of Chemistry [Online], 7.2 (2016): 161-165. Web. 16 Sep. 2019
Al-Shibly, Ahmed, Monir, Hany, El-Ghobashy, Mohamed, AND Amer, Sawsan. "Determination of binary mixture of ibuprofen and famotidine by different spectrophotometric methods" European Journal of Chemistry [Online], Volume 7 Number 2 (30 June 2016)

DOI Link: https://doi.org/10.5155/eurjchem.7.2.161-165.1407

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