European Journal of Chemistry 2016, 7(3), 290-297. doi:10.5155/eurjchem.7.3.290-297.1438

Silver and zinc oxide nanoparticles as potential weapons for enhancement of antibiotics activity against multi drug resistant microorganisms


Kholoud Mohammed Abou El-Nour (1) , Alaa Mohammed Hassan (2) , Omar Abdulrahman Abdulwahid (3,*)

(1) Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt
(2) Department of Botany, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt
(3) Department of Botany, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt
(*) Corresponding Author

Received: 09 Apr 2016, Accepted: 21 May 2016, Published: 30 Sep 2016

Abstract


Some microorganisms became less sensitive to several ordinary used antibiotics, causing the outbreak of infectious diseases. Therefore, the present study is carried out to investigate the antibacterial properties of silver and zinc oxide nanoparticles. Their physicochemical properties as well as the combined effects of antibiotics previously impregnated with the metal and metal oxide nanoparticles. Silver nanoparticles (AgNPs) were obtained using the chemical reduction method, while zinc oxide nanoparticles (ZnONPs) were synthesized using the precipitation method followed by calcination process. The formed nanoparticles (Nps) were characterized using UV-Visible spectroscopy, Fourier Transforms Infrared Spectroscopy (FT-IR), X-ray diffraction analysis (XRD) and Transmission Electron Microscopy (TEM). The antibacterial effect of AgNPs and ZnONPs was tested against four different genera: Staphylococcus aureus (Gram positive), Shigella boydii (Gram negative), Klebsiella pneumoniae (Gram negative) and Escherichia coli (Gram negative) and showed strong effect against all. Also, the synthesized nanoparticles were evaluated for their role in increasing the antibacterial activity of ten tested antibiotics which cover most antibiotics groups according to their mechanism of action. Enhancement in the antibiotic activities was recognized via increasing inhibition zone diameters (mm).


Keywords


Antibacterial effect; Silver nanoparticles; Precipitation method; Zinc oxide nanoparticles; Antibiotics enhancement; Chemical reduction method

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DOI: 10.5155/eurjchem.7.3.290-297.1438

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How to cite


El-Nour, K.; Hassan, A.; Abdulwahid, O. Eur. J. Chem. 2016, 7(3), 290-297. doi:10.5155/eurjchem.7.3.290-297.1438
El-Nour, K.; Hassan, A.; Abdulwahid, O. Silver and zinc oxide nanoparticles as potential weapons for enhancement of antibiotics activity against multi drug resistant microorganisms. Eur. J. Chem. 2016, 7(3), 290-297. doi:10.5155/eurjchem.7.3.290-297.1438
El-Nour, K., Hassan, A., & Abdulwahid, O. (2016). Silver and zinc oxide nanoparticles as potential weapons for enhancement of antibiotics activity against multi drug resistant microorganisms. European Journal of Chemistry, 7(3), 290-297. doi:10.5155/eurjchem.7.3.290-297.1438
El-Nour, Kholoud, Alaa Mohammed Hassan, & Omar Abdulrahman Abdulwahid. "Silver and zinc oxide nanoparticles as potential weapons for enhancement of antibiotics activity against multi drug resistant microorganisms." European Journal of Chemistry [Online], 7.3 (2016): 290-297. Web. 21 Oct. 2019
El-Nour, Kholoud, Hassan, Alaa, AND Abdulwahid, Omar. "Silver and zinc oxide nanoparticles as potential weapons for enhancement of antibiotics activity against multi drug resistant microorganisms" European Journal of Chemistry [Online], Volume 7 Number 3 (30 September 2016)

DOI Link: https://doi.org/10.5155/eurjchem.7.3.290-297.1438

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