Email this article 
Hide
Show all
OPEN ACCESS | 
PEER-REVIEWED |
RESEARCH ARTICLE
|
DOWNLOAD PDF
|
VIEW FULL-TEXT PDF
| TOTAL VIEWS
Novel approach for UPLC-ESI-Tandem mass spectrometric method for simultaneous determination of olmesartan medoxomil and hydrochlorothiazide in their pharmaceutical combination with kinetic studies of forced degradation
Ahmed Abdalazim Mostafa (1,*)
, Maha Mahmoud Abou-El Alamin (2) (1) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, 11795, Cairo, Egypt
(2) Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, 11795, Cairo, Egypt
(*) Corresponding Author
Received: 11 May 2016 | Revised: 21 Jun 2016 | Accepted: 02 Jul 2016 | Published: 30 Sep 2016 | Issue Date: September 2016
Abstract
A simple, robust ultra-performance liquid chromatography coupled to ESI-Tandem mass spectrometric (UPLC-MS/MS) technique was developed for the simultaneous quantitation of olmesartan medoxomil (OLM) and hydrochlorothiazide (HCT) in bulk and their combined pharmaceutical formulation. Chromatographic separation was done on a Hypersil gold 50×2.1 mm (1.9 μm) column, with gradient elution of mobile phase consisted of acetonitrile and 0.1% formic acid aqueous solution. Detection of analytes was carried out using selective reaction monitoring (SRM) mode on a triple quadrupole mass spectrometer coupled with electrospray ionization (ESI). Linearity was achieved over concentration ranges of 2.0-200.0 and 3.0-50.0 ng/mL for OLM and HCT, respectively. Intra and inter day reproducibility were acceptable. The lower limits of detection were found to be 0.627 and 0.583 ng/mL and lower limits of quantitation were 1.900 and 1.767 ng/mL for OLM and HCT, respectively. The method was successfully applied for determination the cited drugs in their combined pharmaceutical dosage form. The method was applied to study the kinetic of forced degradation of both drugs under different conditions. The method was validated according to ICH guidelines and there is no significance difference between the proposed method and the reported method. The simplicity and sensitivity of this method allows the utilization of method in quality control of the cited drugs.
Announcements
Our editors have decided to support scientists to publish their manuscripts in European Journal of Chemistry without any financial constraints.
1- The article processing fee will not be charged from the articles containing the single-crystal structure characterization or a DFT study between September 15, 2023 and October 31, 2023 (Voucher code: FALL2023).
2. A 50% discount will be applied to the article processing fee for submissions made between September 15, 2023 and October 31, 2023 by authors who have at least one publication in the European Journal of Chemistry (Voucher code: AUTHOR-3-2023).
3. Young writers will not be charged for the article processing fee between September 15, 2023 and October 31, 2023 (Voucher code: YOUNG2023).
Editor-in-Chief
European Journal of Chemistry
Keywords
Full Text:
PDF
DOI: 10.5155/eurjchem.7.3.309-314.1450
Links for Article
| | | | | | |
| | | | | | |
| | | |
Related Articles
Article Metrics
This Abstract was viewed 1518 times |
PDF Article downloaded 545 times
Funding information
The Pharmaceutical Services Centre and LC-MS Unit, Faculty of Pharmacy, Helwan University, Cairo, Egypt
Citations
[1]. Selvia Maged Adly, Maha Mohamed Abdelrahman, Nada Sayed Abdelwahab, Nourudin Wageh Ali
Different spectrophotometric and TLC-densitometric methods for determination of olmesartan medoxomil and hydrochlorothiazide and their degradation products
European Journal of Chemistry 9(4), 400, 2018
DOI: 10.5155/eurjchem.9.4.400-407.1784
[2]. Mohamed M. Al-Sanea, Mohamed A. Abdelgawad, Khalid S. Alharbi, Selvia M. Adly, Nada S. Abdelwahab, Nourudin W. Ali, Maha M. Abdelrahman
Simultaneous analysis of several antihypertensive drugs in different combinations: Application for determination of drug degradation products and process impurities
Microchemical Journal 166, 106203, 2021
DOI: 10.1016/j.microc.2021.106203
References
[1]. Bramlage, P.; Zemmrich, C.; Ketelhut, R.; Wolf, W. P.; Fronk, E. M.; Schmieder, R. E. Vasc. Health Risk Manag. 2013, 9, 475-483.
http://dx.doi.org/10.2147/VHRM.S49118
[2]. Mohan, J. C.; Jain, R.; Chamle, V.; Bhargava, A. J. Clin. Diagn. Res. 2015, 9(8), OC10-3.
[3]. Chrysant, S. G.; Weber, M. A.; Wang, A. C.; Hinman, D. J. Am. Soc. Hypertens 2004, 17, 252-259.
http://dx.doi.org/10.1016/j.amjhyper.2003.11.003
[4]. Sellin, L.; Stegbauer, J.; Laeis, P.; Rump, L. C. J. Hyperten. 2005, 23, 2083-2092.
http://dx.doi.org/10.1097/01.hjh.0000186022.74245.01
[5]. Laeis, P.; Püchler, K.; Kirch, W. J. Hypertens Suppl. 2001, 19(1), S21-32.
http://dx.doi.org/10.1097/00004872-200106001-00004
[6]. Rote, A. R.; Bari, P. D. Indian J. Pharm. Sci. 2010, 72, 111-113.
http://dx.doi.org/10.4103/0250-474X.62245
[7]. Merey, H. A.; Ramadan, N. K.; Diab, S. S.; Moustafa, A. A. Spectrochim. Acta A 2014, 125, 138-146.
http://dx.doi.org/10.1016/j.saa.2014.01.095
[8]. Darwish, H. W. Chem. Cent. J. 2013, 7, 22-22.
http://dx.doi.org/10.1186/1752-153X-7-22
[9]. Solanki, T. B.; Shah, P. A.; Patel, K. G. Indian J. Pharm. Sci. 2014, 76, 179-187.
[10]. Verma, P. K.; Kamboj, V. K. Pak. J. Pharm. Sci. 2013, 26(1), 209-215.
[11]. Vidyadhara, S.; Reddyvalam, L. C. S.; Rao, B. V.; Tejaswi, K.; Reshma, M. Oriental J. Chem. 2014, 30(1), 195-201.
[12]. Yunoos, M.; Sankar, D. G. Int. J. Pharm. Sci. Drug. Res. 2015, 7(3), 290-297.
[13]. Srikanth, R. R.; Murali, K. R.; Vekaria, N. A.; Rao, S. V.; Mantena, B. P. V. J. Chromatogr. B. 2015, 38, 1343-1354.
[14]. Gorain, B.; Choudhury, H.; Biswas, E.; Barik, A.; Jaisankar, P.; Pal, T. K. RSC Advances 2013, 3, 10887-10893.
http://dx.doi.org/10.1039/c3ra41452c
[15]. Kumar, A.; Verma, P. R. P.; Monif, T.; Khuroo, A. H.; Iyer, S. S.; Singh, A. K. J. Chromatogr. B. 2012, 35, 59-78.
[16]. Chae, J. W.; Baek, I. H.; Seo, J. W.; Jung, S. H.; Back, H. M.; Song, B. J.; Lee, B. Y.; Yun, H. Y.; Kang, W.; Kwon, K. I. Int. J. Clin. Pharmacol. Ther. 2014, 52(8), 676-683.
http://dx.doi.org/10.5414/CP202046
[17]. Ebeid, W. M.; Elkady, E. F.; El-Zaher, A. A.; El-Bagary, R. I.; Patonay, G. Anal. Bioanal. Chem. 2014, 406, 6701-6712.
http://dx.doi.org/10.1007/s00216-014-8085-0
[18]. Kumar, K. K.; Rao, C. K.; Madhusudan, G.; Mukkanti, K. Am. J. Analyt. Chem. 2012, 3, 50-58.
http://dx.doi.org/10.4236/ajac.2012.31008
[19]. Jain, P. S.; Patel, M. K.; Gorle, A. P.; Chaudhari, A. J.; Surana, S. J. J. Chromatogr. Sci. 2012, 50, 680-687.
http://dx.doi.org/10.1093/chromsci/bms067
[20]. Mowaka, S.; Mohamed, D. RSC Advances 2015, 5, 60467-60481.
http://dx.doi.org/10.1039/C5RA11448A
[21]. Mohamed, D; Mowaka, S.; Mostafa, A. Eur. J. Chem. 2014, 5, 181-85.
http://dx.doi.org/10.5155/eurjchem.5.1.181-185.942
[22]. ICH Harmonized Tripartite Guideline, Validation of Analytical Procedures: Text and Methodology, Q2(R1), Current Step 4 Version, Parent Guidelines on Methodology, 2005.
[23]. Shrivastava, A.; Gupta, V. Methods for the determination of limit of detection and limit of quantitation of the analytical methods, 2011; Vol. 2.
[24]. El-Gizawy, S. M.; Abdelmageed, O. H.; Omar, M. A.; Deryea, S. M.; Abdel-Megied, A. M. Am. J. Analyt. Chem. 2012, 3, 422-430.
http://dx.doi.org/10.4236/ajac.2012.36055
[25]. Adamovics, J. A. Chromatographic analysis of pharmaceuticals; Marcel Dekker Inc., New York, 1997.
[26]. ICH Harmonized Tripartite Guideline, Validation of Analytical Procedures: Text and Methodology, Q2 (R1), Current Step 4 Version, Parent Guidelines on Methodology Dated November 6; 1996, incorporated in November 2005.
[27]. Murakami, T.; Konno, H.; Fukutsu, N.; Onodera, M.; Kawasaki, T.; Kusu, F. J. Pharm. Biomed. Anal. 2008, 47, 553-559.
http://dx.doi.org/10.1016/j.jpba.2008.02.021
[28]. Mahajan, A. A.; Thaker, A. K.; Mohanraj, K. J. Brazilian Chem. Soc. 2012, 23, 445-452.
[29]. Gorog, S. J. Pharm. Biomed. Anal. 2008, 48, 247-253.
http://dx.doi.org/10.1016/j.jpba.2007.10.038
[30]. Florence, D. A. A. T. Physicochemical Principles of Pharmacy, Macmillan Press, London 1998.
http://dx.doi.org/10.1007/978-1-349-14416-7
How to cite
The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item
DOI Link: https://doi.org/10.5155/eurjchem.7.3.309-314.1450
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
Save to Zotero
Save to Mendeley
European Journal of Chemistry 2016, 7(3), 309-314 | doi: https://doi.org/10.5155/eurjchem.7.3.309-314.1450 | Get rights and content
Refbacks
- There are currently no refbacks.
Copyright (c)
© Copyright 2010 - 2023 • Atlanta Publishing House LLC • All Right Reserved.
The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.
Copyright 2010-2023 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.