Email this article 
Hide
Show all
OPEN ACCESS | 
PEER-REVIEWED |
RESEARCH ARTICLE
|
DOWNLOAD PDF
|
VIEW FULL-TEXT PDF
| TOTAL VIEWS
Utilization of oxidation-reduction reaction of Folin-Ciocalteu’s phenol reagent in colorimetric determination of amlodipine in pharmaceutical dosage form
Ali Alshabrawy (1)
, Ahmed Mostafa (2,*) , Nageh Abotaleb (3) (1) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, 11795, Egypt
(2) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, 11795, Egypt
(3) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, 11795, Egypt
(*) Corresponding Author
Received: 12 May 2016 | Revised: 21 Jun 2016 | Accepted: 26 Jun 2016 | Published: 31 Dec 2016 | Issue Date: December 2016
Abstract
A simple visible spectrophotometric method has been developed for determination of amlodipine in commercial tablets. Amlodipine (AMO) is 1,4-dihydropyridine derivative, this group when reacted with Folin-Ciocaluts phenol reagent in presence of 10% sodium carbonate, intense blue color was formed that exhibits maximum absorbance at wave length 745 nm. The intensity of color was found to be affected by many parameters. Optimization of the method parameters was done. The method was validated over a concentration range of 10 to 110 µg/mL. The values of each validation items were within the acceptable range for precision and accuracy. The lower limit for quantitation and lower of detection were founded to be 3.21 and 9.72 µg/mL, respectively. The proposed method was successfully applied to the quantitative determination of amlodipine in tablets without interference from tablet additives. The simplicity and accuracy of this method will allow many laboratories to determine the concentration of amlodipine in dosage form in easy way.
Announcements
Our editors have decided to support scientists to publish their manuscripts in European Journal of Chemistry without any financial constraints.
1- The article processing fee will not be charged from the articles containing the single-crystal structure characterization or a DFT study between September 15, 2023 and October 31, 2023 (Voucher code: FALL2023).
2. A 50% discount will be applied to the article processing fee for submissions made between September 15, 2023 and October 31, 2023 by authors who have at least one publication in the European Journal of Chemistry (Voucher code: AUTHOR-3-2023).
3. Young writers will not be charged for the article processing fee between September 15, 2023 and October 31, 2023 (Voucher code: YOUNG2023).
Editor-in-Chief
European Journal of Chemistry
Keywords
Full Text:
PDF
DOI: 10.5155/eurjchem.7.4.387-390.1451
Links for Article
| | | | | | |
| | | | | | |
| | | |
Related Articles
Article Metrics
This Abstract was viewed 1532 times |
PDF Article downloaded 606 times
Funding information
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, 11795, Egypt
References
[1]. Mancia, G.; Asmar, R.; Amodeo, C.; Mourad, J. J.; Taddei, S.; Gamba, M. A. A.; Chazova, I. E.; Puig, J. G. J. Hypertens. 2015, 33, 401-411.
http://dx.doi.org/10.1097/HJH.0000000000000409
[2]. Khan, M. G. Cardiac Drug Therapy, 7th ed.; Humana Press, Totowa, New Jersey, USA, 2007.
[3]. Tiwari, R. N.; Shah, N.; Bhalani, V.; Mahajan, A. J. Pharm. Anal. 2015, 5, 33-42.
http://dx.doi.org/10.1016/j.jpha.2014.07.005
[4]. Wang, B.; Sheng, L.; Li, Y. J. Chromatogr. Sci. 2015, 53(10), 1708-1713.
[5]. Bodapati, K.; Vaidya, J. R.; Siddiraju, S.; Gowrisankar, D. J. Liq. Chrom. Relat. Tech. 2015, 38, 259-270.
http://dx.doi.org/10.1080/10826076.2014.903851
[6]. Gadepalli, S. G.; Deme, P.; Kuncha, M.; Sistla, R. J. Pharm. Anal. 2014, 4, 399-406.
http://dx.doi.org/10.1016/j.jpha.2013.12.003
[7]. Erden, P. E.; Tasdemir, I.; Kacar, C.; Kilic, E. Int. J. Electrochem. Sci. 2014, 9, 2208-2220.
[8]. Inglot, T.; Gumieniczek, A.; Mączka, P.; Rutkowska, E. Am. J. Anal. Chem. 2013, 4, 17-23.
http://dx.doi.org/10.4236/ajac.2013.41003
[9]. Yacoub, M.; Alawi, M.; Arafat, T. J. Chromatogr. B Biomed. Sci. Appl. 2013, 917, 36-47.
[10]. Banerjee, S. K.; Vasava, N. M. Bull. Pharm. Res. 2013, 3(1), 29-33.
[11]. Tengli, A. R.; Gurupadayya, B.; Soni, N. Int. J. Chem. Ana. Sci. 2013, 4, 33-38.
http://dx.doi.org/10.1016/j.ijcas.2013.03.003
[12]. Leite, H. D.; Santoro, M. I. R.; Porto, J.; Garcia, P. L.; Almeida, M. M. d.; Tavares, V. F.; Kedor-Hackmann, E. R. Am. J. Pharm. 2011, 30, 527-533.
[13]. Liu, W.; Zhang, Q. Herald of Medicine 2010, 6, 698-701.
[14]. Zarghi, A.; Foroutan, S.; Shafaati, A.; Khoddam, A. Il Farmaco 2005, 60, 789-792.
http://dx.doi.org/10.1016/j.farmac.2005.06.012
[15]. El-Kosasy, A. M.; Tawakkol, S. M.; Ayad, M. F.; Sheta, A. I. Talanta 2015, 143, 402-413.
http://dx.doi.org/10.1016/j.talanta.2015.05.012
[16]. Ibrahim, F.; El‐Enany, N.; Shalan, S.; Abo-Shabana, R. Luminescence 2015, 30(7), 1011-1019.
http://dx.doi.org/10.1002/bio.2852
[17]. Gohil, K.; Trivedi, P.; Molvi, K. Indian J. Pharm. Sci. 2005, 67, 376-378.
[18]. Shama, S. A.; Amin, A. S.; Mabrouk, E. S. M.; Omara, H. A. Arabian J. Chem. 2009, 2, 59-63.
http://dx.doi.org/10.1016/j.arabjc.2009.07.002
[19]. Almani, F.; Rind, F.; Memon, A.; Mughal, U.; Laghari, M.; Memon, N.; Maheshwari, M.; Khuhawar, M. Chem. Asian J. 2010, 22, 1205-1213.
[20]. Lakshmi, A. G.; Dhachinamoorthi, D.; Rao, J.; Rao, C.; Surekha, M. Res. J. Pharm. Technol. 2011, 4, 1432-1435.
[21]. Salem, H.; Mohamed, D. Spectrochim. Acta A 2015, 140, 166-173.
http://dx.doi.org/10.1016/j.saa.2014.12.099
[22]. Basavaiah, K.; Kumar, U. R. A. E-J. Chem. 2006, 3(4), 242-249.
[23]. Kazemipour, M.; Ansari, M.; Mohammadi, A.; Beitollahi, H.; Ahmadi, R. J. Anal. Chem. 2009, 64, 65-70.
http://dx.doi.org/10.1134/S1061934809010134
[24]. Goyal, R. N.; Bishnoi, S. Bioelectrochemistry 2010, 79, 234-240.
http://dx.doi.org/10.1016/j.bioelechem.2010.06.004
[25]. Stoiljkovic, Z. Z.; Avramov, I. M. L.; Petrovic, S. D.; Mijin, D. Z.; Stevanovic, S. I.; Lacnjevac, U. C.; Marinkovic, A. D. Int. J. Electrochem. Sci. 2012, 7, 2288-2303.
[26]. Basavaiah, K.; Prameela, H. C. Il Farmaco 2002, 57, 443-449.
http://dx.doi.org/10.1016/S0014-827X(02)01237-5
[27]. Ramesh, P. J.; Basavaiah, K.; Rajendraprasad, N. Acta Pharmaceutica 2010, 60, 445-454.
http://dx.doi.org/10.2478/v10007-010-0032-9
[28]. Swamy, N.; Prashanth, K. N.; Basavaiah, K.; Vinay, K. B. FABAD J. Pharm. Sci. 2012, 37(3), 141-149.
[29]. Ramesh, P. J.; Basavaiah, K.; Rajendraprasad, N.; Devi, O. Z.; Vinay, K. B. J. Appl. Spectrosc. 2011, 78, 383-391.
http://dx.doi.org/10.1007/s10812-011-9480-3
[30]. Maslov, K.; Egorov, A.; Akimova, T.; Kaminski, V. Chem. Heterocycl. Compd. 2002, 38, 560-563.
http://dx.doi.org/10.1023/A:1019509212864
[31]. ICH Harmonized Tripartite Guidelines. Validation of Analytical Procedures: Text and Methodology, Q2 (R1), Current Step 4 Version, Parent Guidelines on Methodology dated November 6 1996, Incorporated in November 2005.
[32]. Abdelrahman, M. M. J. Iran Chem. Soc. 2015, 12, 1439-1446.
http://dx.doi.org/10.1007/s13738-015-0612-1
[33]. Walash, M. I.; Rizk, M.; Sheribah, Z. A.; Salim, M. M. Int. J. Biomed. Res. 2008, 4, 238-244.
How to cite
The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item
DOI Link: https://doi.org/10.5155/eurjchem.7.4.387-390.1451
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
Save to Zotero
Save to Mendeley
European Journal of Chemistry 2016, 7(4), 387-390 | doi: https://doi.org/10.5155/eurjchem.7.4.387-390.1451 | Get rights and content
Refbacks
- There are currently no refbacks.
Copyright (c)
© Copyright 2010 - 2023 • Atlanta Publishing House LLC • All Right Reserved.
The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.
Copyright 2010-2023 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.