European Journal of Chemistry

Synthesis, characterization and biological activity study of some new palladium(II) complexes containing amine or azomethine groups

Main Article Content

Adil Ali Al-Fregi
Ahmed Laith Al-Fadhly
Bushra Kamel Al-Salami


This study reports the preparative methods of two types of palladium(II) complexes. The first method revealed two newly palladium (II) complexes derived from bidentate amine ligands, and the second one describes six newly palladium(II) complexes derived from bidentate Schiff base ligands. All the synthesized complexes have been characterized by elemental analysis, conductivity measurements, UV-Visible, FT-IR and 1H NMR spectral data. In vitro, all the synthesized complexes have been tested for their growth inhibitory activity against Gram negative bacteria Escherichia coli and Gram positive Staphylococcus aureus as well as determining the minimum inhibitory concentration. In addition, the interactions between compounded complexes and human DNA were also studied.

icon graph This Abstract was viewed 1458 times | icon graph Article PDF downloaded 620 times

How to Cite
Al-Fregi, A. A.; Al-Fadhly, A. L.; Al-Salami, B. K. Synthesis, Characterization and Biological Activity Study of Some New palladium(II) Complexes Containing Amine or Azomethine Groups. Eur. J. Chem. 2017, 8, 155-161.

Article Details

Crossref - Scopus - Google - European PMC

[1]. Cragg, G. M.; Grothaus, P. G.; Newman, D. J. Chem. Rev. 2009, 109, 3012-3043.

[2]. Fuertes, A. M. A.; Perez, J. M. Chem. Rev. 2003, 103(3), 645-658.

[3]. Boulikas, T.; Vougiouka, M. Oncol. Reports 2003, 10, 1663-1671.

[4]. Bertini, I.; Gray, H. I.; Valentine, J. S. Biological Inorganic Chemistry: Structure and Reactivity, Science Books, Mill- Valley Publ., CA, 2005.

[5]. Galanski, M. V.; Arion, B.; Jakupec, M. A.; Keppler, B. K. Curr. Pharm. Design 2003, 9(25), 2078-2086.

[6]. Prestayko, A. W.; Crooke, S. T.; Carter, S. K. Cis-platin: Current Status and New Development, Academic Press, New York, 1980.

[7]. Mansori-Torshizi, H.; Saeidifar, M. F.; Khosravi, A.; Sabury, A. A.; Ghasemi, Z. Y. Bull. Korean Chem. Soc. 2011, 32, 947-956.

[8]. Abu-Surrah, A. S.; Al-Sa'doni, H. H.; Abdalla, M. Y. Cancer Therapy 2008, 6, 1-10.

[9]. Abu-Surrah, A. S.; Kettunen, M. Curr. Mid. Chem. 2006, 13, 1337-1357.

[10]. Dyson, P. J.; Sava, G. Dalton Trans. 2006, 16, 1929-1933.

[11]. Farrell, N., Metal Complexes in Tumor Diagnosis and as Anticancer Agents, Metal Ions in Biological Systems, Sigel, A.; Sigel, H. (eds.), Arcel Dekker, Inc, New York, 2004, 42.

[12]. Gill, D. S.; Hacker, M. P.; Douple, E. B.; Krakoff, I. H. Platinum Coordination in Cancer Chemotherapy, Martinus Nijhoff, Boston, 1984, pp. 267-273.

[13]. Mansori-Torshizi, H.; Srivastava, T. S.; Parekh, H. K.; Chitnis, M. P. J. Inorg. Biochem. 1992, 45, 145-153.

[14]. Abu-Surrah, A. S.; Al-Allaf, T. A. K.; Rashan, L. J.; Kilinga, M.; Leskela, M. Eur. J. Med. Chem. 2002, 37, 919-926.

[15]. Monneret, C. Ann. Pharm. Francaises 2011, 69, 286-293.

[16]. Marques, M. P. M.; Batista de Carvalho, L. A. E. Biomed. Soc. Trans. 2007, 35, 374-385.

[17]. Ornelas, C.; New J. Chem. 2011, 35, 1973-1980.

[18]. Zayed, E. M.; Zayed, M. A. Spectrochim. Acta A 2015, 143, 81-89.

[19]. Azhar, S.; Najam-Ul-Haq, M.; Atif, M.; Khan, S. A.; Alam, A. Acta Polon. Pharm. Drug Res. 2014, 71(4), 52-61.

[20]. Chatterjee, S.; Bhattacharyya, S. Asian J. Biochem. Pharm. Res. 2015, 5(4), 86-94.

[21]. Bushra, K.; Al-Fadhly, A. L.; Al-Fregi, A. A. Der Pharma Chemica 2016, 8(19), 488-496.

[22]. Doyle, J. R.; Slade, P. E.; Jonassen, H. B. Inorg. Synth. 1960, 6, 218-226.

[23]. Sheikh, C.; Hossain, M. S.; Easmin, M. S.; Rashid, M. Pak. J. Biol. Sci. 2004, 7(3), 333-341.

[24]. Hoog, D.; Boldrn, C. J. Med. Chem. 2007, 50, 3148-3158.

[25]. Sambrook, J.; Fritsch, E.; Mainiatis, T., Molecular cloning, a laboratory manual, Cold Spring Harbor Laboratory Press, New York, 1989.

[26]. Al-Fregi, A. A. Inter. J. Adv. Res. 2015, 3(3), 637-647.

[27]. Al-Fregi, A. A.; Adnan, M. A. Eur. J. Chem. 2016, 7(2), 195-200.

[28]. Silverstien, R. M.; Webster, F. X.; Kiemle, D. J. Spectrometric Identification of Organic Chemistry Compounds, 6th Ed., John Wiley and Sons, NY, 2005.

[29]. Husain, D. M.; Al-Fregi, A. A. Int. J. Appl. Sci. Techn. 2012, 2(4), 83-89.

[30]. Al-Assadi, M. J. B.; Al-Fregi, A. A.; Al-Wa'aly, A. A. S. Basrah J. Sci. C 2003, 21(1), 33-44.

[31]. Nakamoto, K. Infrared and Raman Spectra of Organic and Coordination Compounds, 7th Ed., John Wiley and Sons Ltd., USA, 2009.

[32]. Shriner, R. I.; Hermann, C. K. Spectroscopic Techniques for Organic Chemistry, John Wiley and Sons, N.Y., 2004.

[33]. Saadon, H. L.; Ali, B.; Al-Fregi, A. A. Optics Laser Techn. 2014, 58, 33-38.

[34]. Badran, H. A.; Al-Fregi, A. A. Int. J. Phys. Res. 2012, 2(1), 14-25.

[35]. Gray, H. B.; Sohn, Y. S.; Hendrickson, N. J. Amer. Chem. Soc. 1971, 93(15), 3603-3612.

[36]. Al-Rubaie, A. Z.; Al-Fregi, A. A.; Al-Jadaan, S. A. S. Phosphorus, Sulfur, and Silicon Relat. Elem. 2011, 186, 115-124.

[37]. Al-Fregi, A. A.; Shabeeb, G. M. Amer. Int. J. Res. Form. Appl. Nat. Sci. 2014, 6(20), 161-171.

[38]. Majeed, N. N.; Al-Fregi, A. A.; Abbas, F. A. J. Kerbala Univ. 2012, 10(3), 328-338.

Supporting Agencies

Department of Chemistry, College of Science, University of Basra, 61001, Basrah, Iraq

Dimensions - Altmetric - scite_ - PlumX

Downloads and views


Download data is not yet available.


Metrics Loading ...
License Terms

License Terms


Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License ( By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License ( are administered by Atlanta Publishing House LLC (European Journal of Chemistry).