European Journal of Chemistry

Synthesis, structural elucidation and X-ray crystallographic studies of 1-(3,5-bis(trifluoromethyl)phenyl)-3-(dimethylamino)prop-2-en-1-one

Article Sidebar

PDF CIF FILE
Published: Dec 31, 2019
DOI: https://doi.org/10.5155/eurjchem.10.4.381-385.1922
Keywords:
Enaminones, Acetophenone, Trifluoromethyl, X-ray crystallography, Geometric parameters, N, N-Dimethylformamide dimethyl acetal
Section
Research Article
Issue
Vol. 10 No. 4 (2019): December 2019
Dates
Received 2019-09-03
Accepted 2019-10-06
Published 2019-12-31
Crossmark


Main Article Content

Stability Nongrum
Organic Research Laboratory, Department of Chemical Science, Assam Don Bosco University, Tapesia Gardens, Kamarkuchi, Sonapur, 782 402 Assam, India
http://orcid.org/0000-0002-2427-6007
Susma Das
Organic Research Laboratory, Department of Chemical Science, Assam Don Bosco University, Tapesia Gardens, Kamarkuchi, Sonapur, 782 402 Assam, India
http://orcid.org/0000-0002-2391-8792
Shikpika Khanikar
Organic Research Laboratory, Department of Chemical Science, Assam Don Bosco University, Tapesia Gardens, Kamarkuchi, Sonapur, 782 402 Assam, India
http://orcid.org/0000-0001-9845-2002
Jai Narain Vishwakarma
Organic Research Laboratory, Department of Chemical Science, Assam Don Bosco University, Tapesia Gardens, Kamarkuchi, Sonapur, 782 402 Assam, India
http://orcid.org/0000-0001-9068-4554

Abstract

A new enaminone was synthesized by reacting 3,5-bis-(trifluoromethyl)acetophenones and N,N-dimethylformamide dimethyl acetal and its detailed structural and crystalline properties were studied. The crystal data were found to be as C13H11F6NO, monoclinic, space group P21/c (no. 14), a = 8.1556(8) Å, b = 24.877(3) Å, c = 7.6067(7) Å, β = 116.745(6)°, V = 1378.2(3) Å3, Z = 4, T = 293(2) K, μ(MoKα) = 0.150 mm-1, Dcalc = 1.500 g/cm3, 40777 reflections measured (5.594° ≤ 2Θ ≤ 56.786°), 3413 unique (Rint = 0.1040, Rsigma = 0.0584) which were used in all calculations. The final R1 was 0.0771 (I > 2σ(I)) and wR2 was 0.2541 (all data).


icon graph This Abstract was viewed 1705 times | icon graph Article PDF downloaded 760 times icon graph Article CIF FILE downloaded 0 times

How to Cite
(1)
Nongrum, S.; Das, S.; Khanikar, S.; Vishwakarma, J. N. Synthesis, Structural Elucidation and X-Ray Crystallographic Studies of 1-(3,5-bis(trifluoromethyl)phenyl)-3-(dimethylamino)prop-2-En-1-One. Eur. J. Chem. 2019, 10, 381-385.

Article Details

Share
Links for Article


Crossref - Scopus - Google - European PMC
Crossref
Scopus
Google Scholar
Europe PMC
References

[1]. Musumeci, D.; Irace, C.; Santamaria, R.; Montesarchio, D. Med. Chem. Commun. 2013, 4, 1405-1410.
https://doi.org/10.1039/c3md00159h

[2]. Wang, J.; Sanchez-Rosello, M.; Acena, L. J.; Pozo, del C.; Sorochinsky, E. A.; Fustero, S.; Soloshonok, A. V.; Liu, H. Chem. Rev. 2014, 114, 2432-2506.
https://doi.org/10.1021/cr4002879

[3]. Lisi, H.; Xinkan, Y.; Gavin, C. T. J. Org. Chem. 2017, 82, 6192-6201
https://doi.org/10.1021/acs.joc.7b00755

[4]. Purser, S.; Moore, P. R.; Swallow, S.; Gouverneur, V. Chem. Soc. Rev. 2008, 37, 320-330.
https://doi.org/10.1039/B610213C

[5]. Champagne, A. P.; Desroches, J.; Hamel, J. D.; Vandamme, M.; Paquin, J. F. Chem. Rev. 2015, 115, 9073-9174.
https://doi.org/10.1021/cr500706a

[6]. Charpentier, J.; Fruh, N.; Togni, A. Chem. Rev. 2015, 115, 650-682.
https://doi.org/10.1021/cr500223h

[7]. Vishwakarma, J. N.; Khanikar, S.; Kalita, U.; Kaping S.; Ray, M. Curr. Chem. Lett. 2018, 7, 35-44.
https://doi.org/10.5267/j.ccl.2018.3.001

[8]. Mohamed, A. R.; Omran, A. O. J. Heterocycl. Chem. 2016, 53, 1121-1128.
https://doi.org/10.1002/jhet.2359

[9]. Kalita, U.; Kaping, S.; Nongkynrih, R.; Sunn, M.; Boiss, I.; Singha, I. L.; Vishwakarma, J. N. Med. Chem. Res. 2015, 24(6), 2742-2755.
https://doi.org/10.1007/s00044-015-1332-x

[10]. Kalita, U.; Kaping, S.; Nellanant, J.; Helissey, P.; Vishwakarma, N. J. Heterocyclic Lett. 2014, 4(1), 137-145.

[11]. Bruker, APEX II, Bruker AXS Inc., Madison, WI, USA, 2004.

[12]. Sheldrick, G. M. SHELXS-97 and SHELXL-97, Program for Crystal Structure Solution and Refinement, University of Gottingen, Gottingen, 1997

[13]. Farrugia, L. J. J. Appl. Crystallogr. 1999, 32, 837-838.
https://doi.org/10.1107/S0021889899006020

Supporting Agencies

Department of Biotechnology, Government of India, India.
Most read articles by the same author(s)
TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2025 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).