European Journal of Chemistry 2021, 12(2), 154-158 | doi: https://doi.org/10.5155/eurjchem.12.2.154-158.2065 | Get rights and content

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Reactions under increased pressure: The reactivity of functionally substituted 3-oxo-2-arylhydrazones toward active methylene reagents in Q-tube


Douaa Salman AlMarzouq (1,*) orcid

(1) Department of Environmental Health, College of Health Sciences, The Public Authority of Applied Education and Training, Faiha, 72853, Kuwait
(*) Corresponding Author

Received: 10 Jan 2021 | Revised: 27 Jan 2021 | Accepted: 21 Apr 2021 | Published: 30 Jun 2021 | Issue Date: June 2021

Abstract


A one-pot two-component reaction of 3-oxo-2-arylhydrazones with active methylene nitriles under high pressure in a Q-tube safe reactor was reported. Comparison between conventional and Q-tube safe reactor-assisted synthesis of organic compounds was done by comparing total reaction time and percentage yield. The results show that the compound 5-cyano-6-oxo-1,4-diphenyl-1,6-dihydro-pyridazine-3-carboxylic acid ethyl ester (3) was synthesized within 2 h in a yield of 97%. In addition, the pyrazolo[3,4-c]pyridines 5b and 5c were obtained in yields of 93 and 95% within 1 h reaction time, respectively. The obtained results suggest that Q-tube safe reactor-assisted syntheses were led to higher product yields within very short reaction times.


Keywords


Q-tube; Record time; Green technology; 3-Oxo-2-arylhydrazones; Multi-component reaction; Reaction under increased pressure

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DOI: 10.5155/eurjchem.12.2.154-158.2065

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Funding information


Kuwait University Research Administration-RSP unit general facilities of the Faculty of Science, GFS GS 02/01, GS 03/01, GS 01/05), Kuwait.

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How to cite


AlMarzouq, D. Eur. J. Chem. 2021, 12(2), 154-158. doi:10.5155/eurjchem.12.2.154-158.2065
AlMarzouq, D. Reactions under increased pressure: The reactivity of functionally substituted 3-oxo-2-arylhydrazones toward active methylene reagents in Q-tube. Eur. J. Chem. 2021, 12(2), 154-158. doi:10.5155/eurjchem.12.2.154-158.2065
AlMarzouq, D. (2021). Reactions under increased pressure: The reactivity of functionally substituted 3-oxo-2-arylhydrazones toward active methylene reagents in Q-tube. European Journal of Chemistry, 12(2), 154-158. doi:10.5155/eurjchem.12.2.154-158.2065
AlMarzouq, Douaa. "Reactions under increased pressure: The reactivity of functionally substituted 3-oxo-2-arylhydrazones toward active methylene reagents in Q-tube." European Journal of Chemistry [Online], 12.2 (2021): 154-158. Web. 25 Jul. 2021
AlMarzouq, Douaa. "Reactions under increased pressure: The reactivity of functionally substituted 3-oxo-2-arylhydrazones toward active methylene reagents in Q-tube" European Journal of Chemistry [Online], Volume 12 Number 2 (30 June 2021)

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European Journal of Chemistry 2021, 12(2), 154-158 | doi: https://doi.org/10.5155/eurjchem.12.2.154-158.2065 | Get rights and content

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