European Journal of Chemistry

Reactions under increased pressure: The reactivity of functionally substituted 3-oxo-2-arylhydrazones toward active methylene reagents in Q-tube

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Published: Jun 30, 2021
DOI: https://doi.org/10.5155/eurjchem.12.2.154-158.2065
Keywords:
Q-tube, Record time, Green technology, 3-Oxo-2-arylhydrazones, Multi-component reaction, Reaction under increased pressure
Section
Research Article
Issue
Vol. 12 No. 2 (2021): June 2021
Dates
Received 2021-01-10
Accepted 2021-02-06
Published 2021-06-30
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Douaa Salman AlMarzouq
Department of Environmental Health, College of Health Sciences, The Public Authority of Applied Education and Training, Faiha, 72853, Kuwait
https://orcid.org/0000-0002-4633-8168

Abstract

A one-pot two-component reaction of 3-oxo-2-arylhydrazones with active methylene nitriles under high pressure in a Q-tube safe reactor was reported. Comparison between conventional and Q-tube safe reactor-assisted synthesis of organic compounds was done by comparing total reaction time and percentage yield. The results show that the compound 5-cyano-6-oxo-1,4-diphenyl-1,6-dihydro-pyridazine-3-carboxylic acid ethyl ester (3) was synthesized within 2 h in a yield of 97%. In addition, the pyrazolo[3,4-c]pyridines 5b and 5c were obtained in yields of 93 and 95% within 1 h reaction time, respectively. The obtained results suggest that Q-tube safe reactor-assisted syntheses were led to higher product yields within very short reaction times.


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AlMarzouq, D. S. Reactions under Increased Pressure: The Reactivity of Functionally Substituted 3-Oxo-2-Arylhydrazones Toward Active Methylene Reagents in Q-Tube. Eur. J. Chem. 2021, 12, 154-158.

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