European Journal of Chemistry

Bivalent metal complexes of a novel modified nicotinic acid hydrazide drug: Synthesis, characterization, and anti-tubercular studies

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Cyprian Chunkang Mikwa
Gwendoline Mochia Toh-Boyo
Romanus Nyako Njong
Bridget Ndosiri Ndoye
Christophe Adrien Ndamyabera
Natsuki Katsuumi
Yuta Mitani
Emmanuel Ngwang Nfor
Takashiro Akitsu

Abstract

Iron(II) and manganese(II) complexes of N'-(1-(pyridin-2-yl)ethylidene)nicotinohydrazide (LH) have been synthesized and characterized by elemental analysis, IR, and 1H NMR spectroscopy. The crystal structure of the ligand has been determined by single crystal X-ray diffraction and electronic spectroscopic techniques. Crystal data for LH, C13H12N4O: Orthorhombic, space group Pbcn (no. 60), a = 18.0824(3) Å, b = 7.86555(14) Å, c = 16.1614(3) Å, = 2298.60(7) Å3, Z = 8, T = 103 K, μ(Mo Kα) = 0.093 mm-1, Dcalc = 1.388 g/cm3, 36729 reflections measured (5.042° ≤ 2Θ ≤ 54.966°), 2633 unique (Rint = 0.0224, Rsigma = 0.0124) which were used in all calculations. The final R1 was 0.0383 (F2>2σ(F2)) and wR2 was 0.0988 (all data). The ligand was found to chelate to the metal ions through the azomethine nitrogen and amide oxygen atoms in a bidentate manner. The anti-tubercular activity of the ligand, its iron (II) and manganese (II) complexes were studied against Mycobacterium tuberculosis (ATTC 27294). The results revealed higher activity of the iron (II) complex with MIC value of 8.00±0.83 µM and a moderate activity of the manganese (II) complex having MIC value of 14.20±1.40 µM, compared to the reference drugs having MIC values of 9.41±0.92, 10.74±1.02, 25.34±2.6 µM and parent ligand with MIC value of 17.60±1.80 µM.


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Mikwa, C. C.; Toh-Boyo, G. M.; Njong, R. N.; Ndoye, B. N.; Ndamyabera, C. A.; Katsuumi, N.; Mitani, Y.; Nfor, E. N.; Akitsu, T. Bivalent Metal Complexes of a Novel Modified Nicotinic Acid Hydrazide Drug: Synthesis, Characterization, and Anti-Tubercular Studies. Eur. J. Chem. 2022, 13, 63-68.

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Supporting Agencies

Nanotechnology Platform of Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan, Number JPMXP09S20NR0016 and by a Grant-in-Aid for Scientific Research (KAKENHI) number 20H00336.
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