

Synthesis of novel quinazolinone and fused quinazolinones
Mahmoud Refaee Mahmoud (1)



(1) Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
(2) Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
(3) Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
(*) Corresponding Author
Received: 28 Aug 2010 | Accepted: 04 Jan 2011 | Published: 30 Sep 2011 | Issue Date: September 2011
Abstract
A number of novel quinazolinone derivatives have been synthesized using the readily obtainable 2-[(1Z,3E)-1-benzamido-4-phenyl-1,3-butadien-1-yl]-3,1-benzoxazin-4(H)one (1) via the reaction with different nitrogen nucleophiles such as azines, Schiff’s base, primary aromatic amines, diamines, hydrazine hydrate and hydroxylamine.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.2.3.404-409.267
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Citations
[1]. M.R. Mahmoud, F.S.M. Abu El-Azm
Synthesis and Spectral Study of Novel Benzopyrone and Quinolinone Derivatives
Journal of Chemical Research 37(9), 535, 2013
DOI: 10.3184/174751913X13738962423671

[2]. Manal M. Elshahawi, Ahmed K. EL-Ziaty, Jehan M. Morsy, Aly F. Aly
Synthesis and Insecticidal Efficacy of Novel Bis Quinazolinone Derivatives
Journal of Heterocyclic Chemistry 53(5), 1443, 2016
DOI: 10.1002/jhet.2445

[3]. Mohamed H. Hekal, Fatma S. M. Abu El-Azm
New potential antitumor quinazolinones derived from dynamic 2-undecyl benzoxazinone: Synthesis and cytotoxic evaluation
Synthetic Communications 48(18), 2391, 2018
DOI: 10.1080/00397911.2018.1490433

[4]. Mahmoud R. Mahmoud, Ahmed K. El-Ziaty, Fatma S. M. Abu El-Azm, Mahmoud F. Ismail, Sayed A. Shiba
Utility of Cyano-N-(2-oxo-1,2-dihydroindol-3-ylidene)acetohydrazide in the Synthesis of Novel Heterocycles
Journal of Chemical Research 37(2), 80, 2013
DOI: 10.3184/174751912X13567100793191

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