European Journal of Chemistry 2010, 1(2), 134-139. doi:10.5155/eurjchem.1.2.134-139.71

Novel isoquinoline derivatives from isochromen-1,3-dione


Mahmoud Refaee Mahmoud (1) , Manal Mohamed El-Shahawi (2) , Eman Abd El-Fattah El-Bordany (3) , Fatma Saber Mohamed Abu El-Azm (4,*)

(1) Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
(2) Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
(3) Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
(4) Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
(*) Corresponding Author

Received: 21 Apr 2010, Accepted: 12 May 2010, Published: 15 Jun 2010

Abstract


A number of novel isoquinoline derivatives have been synthesized using the readily obtainable (E)-4-(3,4-dimethoxybenzylidene)-4H-isochromene-1,3-dione, 2, via the reaction with different nitrogen nucleophiles such as cyanoethanoic hydrazide, cyclohexylamine, 2-aminothiophenol and p-toluenesulfonohydrazide. Furthermore, the reactivity of 2 towards thiophenol, and ethylcyanoacetate has been investigated.

1_2_134_139_800



Keywords


Isochromene-1,3-dione; Isoquinolines; 2-Cyanoethanoic hydrazide; Nitrogen nucleophiles

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DOI: 10.5155/eurjchem.1.2.134-139.71

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Citations

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[1]. Mahmoud R. Mahmoud, Manal M. El-Shahawi, Wael S. I. Abou-Elmagd, Mohamed H. Hekal
Novel Synthesis of Isoquinoline Derivatives Derived from (Z)-4-(1,3-Diphenylpyrazol-4-yl)isochromene-1,3-dione
Synthetic Communications  45(14), 1632, 2015
DOI: 10.1080/00397911.2015.1030760
/


[2]. Anuj Kumar, Nikhil Kumar, Partha Roy, S. M. Sondhi, Anuj Sharma
Microwave-assisted synthesis of benzenesulfonohydrazide and benzenesulfonamide cyclic imide hybrid molecules and their evaluation for anticancer activity
Medicinal Chemistry Research  24(10), 3760, 2015
DOI: 10.1007/s00044-015-1414-9
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[3]. Mahmoud R. Mahmoud, Wael S.I. Abou-Elmagd, Hamed A. Derbala, Mohamed H. Hekal
Novel Synthesis of Some Phthalazinone Derivatives
Chinese Journal of Chemistry  29(7), 1446, 2011
DOI: 10.1002/cjoc.201180264
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[4]. Mahmoud Refaee Mahmoud, Manal Mohamed El-Shahawi, Fatma Saber Mohamed Abu El-Azm
Synthesis of novel quinazolinone and fused quinazolinones
European Journal of Chemistry  2(3), 404, 2011
DOI: 10.5155/eurjchem.2.3.404-409.267
/


[5]. Mohamed H. Hekal, Fatma S. M. Abu El-Azm
Efficient MW-Assisted Synthesis of Some New Isoquinolinone Derivatives WithIn VitroAntitumor Activity
Journal of Heterocyclic Chemistry  54(6), 3056, 2017
DOI: 10.1002/jhet.2916
/


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How to cite


Mahmoud, M.; El-Shahawi, M.; El-Bordany, E.; Abu El-Azm, F. Eur. J. Chem. 2010, 1(2), 134-139. doi:10.5155/eurjchem.1.2.134-139.71
Mahmoud, M.; El-Shahawi, M.; El-Bordany, E.; Abu El-Azm, F. Novel isoquinoline derivatives from isochromen-1,3-dione. Eur. J. Chem. 2010, 1(2), 134-139. doi:10.5155/eurjchem.1.2.134-139.71
Mahmoud, M., El-Shahawi, M., El-Bordany, E., & Abu El-Azm, F. (2010). Novel isoquinoline derivatives from isochromen-1,3-dione. European Journal of Chemistry, 1(2), 134-139. doi:10.5155/eurjchem.1.2.134-139.71
Mahmoud, Mahmoud, Manal Mohamed El-Shahawi, Eman Abd El-Fattah El-Bordany, & Fatma Saber Mohamed Abu El-Azm. "Novel isoquinoline derivatives from isochromen-1,3-dione." European Journal of Chemistry [Online], 1.2 (2010): 134-139. Web. 11 Nov. 2019
Mahmoud, Mahmoud, El-Shahawi, Manal, El-Bordany, Eman, AND Abu El-Azm, Fatma. "Novel isoquinoline derivatives from isochromen-1,3-dione" European Journal of Chemistry [Online], Volume 1 Number 2 (15 June 2010)

DOI Link: https://doi.org/10.5155/eurjchem.1.2.134-139.71

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