European Journal of Chemistry

Novel isoquinoline derivatives from isochromen-1,3-dione

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Mahmoud Refaee Mahmoud
Manal Mohamed El-Shahawi
Eman Abd El-Fattah El-Bordany
Fatma Saber Mohamed Abu El-Azm


A number of novel isoquinoline derivatives have been synthesized using the readily obtainable (E)-4-(3,4-dimethoxybenzylidene)-4H-isochromene-1,3-dione, 2, via the reaction with different nitrogen nucleophiles such as cyanoethanoic hydrazide, cyclohexylamine, 2-aminothiophenol and p-toluenesulfonohydrazide. Furthermore, the reactivity of 2 towards thiophenol, and ethylcyanoacetate has been investigated.


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Mahmoud, M. R.; El-Shahawi, M. M.; El-Bordany, E. A. E.-F.; Abu El-Azm, F. S. M. Novel Isoquinoline Derivatives from Isochromen-1,3-Dione. Eur. J. Chem. 2010, 1, 134-139.

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