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Novel isoquinoline derivatives from isochromen-1,3-dione
Mahmoud Refaee Mahmoud (1)
, Manal Mohamed El-Shahawi (2) , Eman Abd El-Fattah El-Bordany (3) , Fatma Saber Mohamed Abu El-Azm (4,*) (1) Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
(2) Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
(3) Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
(4) Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
(*) Corresponding Author
Received: 21 Apr 2010 | Accepted: 12 May 2010 | Published: 15 Jun 2010 | Issue Date: June 2010
Abstract
A number of novel isoquinoline derivatives have been synthesized using the readily obtainable (E)-4-(3,4-dimethoxybenzylidene)-4H-isochromene-1,3-dione, 2, via the reaction with different nitrogen nucleophiles such as cyanoethanoic hydrazide, cyclohexylamine, 2-aminothiophenol and p-toluenesulfonohydrazide. Furthermore, the reactivity of 2 towards thiophenol, and ethylcyanoacetate has been investigated.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.1.2.134-139.71
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Citations
[1]. Mahmoud R. Mahmoud, Manal M. El-Shahawi, Wael S. I. Abou-Elmagd, Mohamed H. Hekal
Novel Synthesis of Isoquinoline Derivatives Derived from (Z)-4-(1,3-Diphenylpyrazol-4-yl)isochromene-1,3-dione
Synthetic Communications 45(14), 1632, 2015
DOI: 10.1080/00397911.2015.1030760
[2]. Anuj Kumar, Nikhil Kumar, Partha Roy, S. M. Sondhi, Anuj Sharma
Microwave-assisted synthesis of benzenesulfonohydrazide and benzenesulfonamide cyclic imide hybrid molecules and their evaluation for anticancer activity
Medicinal Chemistry Research 24(10), 3760, 2015
DOI: 10.1007/s00044-015-1414-9
[3]. Mahmoud R. Mahmoud, Wael S.I. Abou-Elmagd, Hamed A. Derbala, Mohamed H. Hekal
Novel Synthesis of Some Phthalazinone Derivatives
Chinese Journal of Chemistry 29(7), 1446, 2011
DOI: 10.1002/cjoc.201180264
[4]. Mahmoud Refaee Mahmoud, Manal Mohamed El-Shahawi, Fatma Saber Mohamed Abu El-Azm
Synthesis of novel quinazolinone and fused quinazolinones
European Journal of Chemistry 2(3), 404, 2011
DOI: 10.5155/eurjchem.2.3.404-409.267
[5]. Mohamed H. Hekal, Fatma S. M. Abu El-Azm
Efficient MW-Assisted Synthesis of Some New Isoquinolinone Derivatives WithIn VitroAntitumor Activity
Journal of Heterocyclic Chemistry 54(6), 3056, 2017
DOI: 10.1002/jhet.2916
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DOI Link: https://doi.org/10.5155/eurjchem.1.2.134-139.71
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