CsCO3-mediated facile synthesis, characterizations, and biological activities of 4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-ylidene)acetonitrile derivatives

Atul Shivaji Patil; Raosaheb Shivaji Patil; Pramod Pandurang Mahulikar; Gautam Prabhakar Sadawarte; Jamatsing Dabarsing Rajput

doi:10.5155/eurjchem.17.1.13-18.2727

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Published: Mar 31, 2026

DOI: https://doi.org/10.5155/eurjchem.17.1.13-18.2727

Keywords:

Cs2CO3, 2H-Pyran-2-one, Antioxidant activity, Pyrimidin-4-ylidene, Ring transformations, Antimicrobial activity

Section

Research Article

Issue

Vol. 17 No. 1 (2026): March 2026

Dates

Received 2025-12-03
Accepted 2026-02-15
Published 2026-03-31

Atul Shivaji Patil

School of Chemical Sciences, Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon, 425 001, India

https://orcid.org/0000-0001-9831-5526

Raosaheb Shivaji Patil

Vasantrao Naik Art’s, Science and Commerce College Dharni, Amravati, 444702, India

https://orcid.org/0000-0002-9173-8769

Pramod Pandurang Mahulikar

School of Chemical Sciences, Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon, 425 001, India

https://orcid.org/0000-0001-6648-9871

Gautam Prabhakar Sadawarte

Department of Chemistry, Faculty of Bhagirathi Purnapatre Arts, Sitabai Mangilal Agrawal Science and Kasturbai Khandu Chaudhari Commerce College Chalisgaon, Maharashtra, 424101, India

https://orcid.org/0000-0003-2002-0052

Jamatsing Dabarsing Rajput

Department of Chemistry, Faculty of Bhagirathi Purnapatre Arts, Sitabai Mangilal Agrawal Science and Kasturbai Khandu Chaudhari Commerce College Chalisgaon, Maharashtra, 424101, India

https://orcid.org/0000-0002-4588-1345

Abstract

In this study, we report the newer method for the synthesis of 4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-ylidene) acetonitrile and the biological activities of the derivatives were systematically evaluated. The antimicrobial potential of the compounds was assessed against three bacterial and three fungal strains using the agar diffusion method. Among the derivatives tested, compounds 3b, 3e, and 3h demonstrated notable antibacterial and antifungal activities. Furthermore, the antioxidant capacity of the selected compounds was investigated through the DPPH radical scavenging assay. Compounds 3e and 3f exhibited significant radical scavenging activity, achieving effective inhibition at a concentration of 0.1 mg/mL. These findings highlight the promising antimicrobial and antioxidant properties of the investigated thiazolopyrimidine derivatives and support their potential for further biological and pharmacological studies.

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Patil, A. S.; Patil, R. S.; Mahulikar, P. P.; Sadawarte, G. P.; Rajput, J. D. CsCO3-Mediated Facile Synthesis, Characterizations, and Biological Activities of 4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-ylidene)acetonitrile Derivatives. Eur. J. Chem. 2026, 17, 13-18.

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Supporting Agencies

Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon, 425 001, India.

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