European Journal of Chemistry 2010, 1(2), 73-75. doi:10.5155/eurjchem.1.2.73-75.34

Synthesis, characterization and crystal structure of 1-(4-methylbenzoyl)-3-(4 aminosulfonylphenyl)thiourea


Aamer Saeed (1,*) , Amara Mumtaz (2) , Ulrich Florke (3)

(1) Department of Chemistry, Quaid-I-Azam University, Islamabad, 45320, Pakistan
(2) Department of Chemistry, Quaid-I-Azam University, Islamabad, 45320, Pakistan
(3) Department Chemie, Fakultät fur Naturwissenschaften, Universitat Paderborn, Warburgerstrasse 100, D-33098, Paderborn, Germany
(*) Corresponding Author

Received: 04 Apr 2010, Accepted: 09 Apr 2010, Published: 15 Jun 2010

Abstract


An efficient synthesis of the title compound, 1-(4-methylbenzoyl)-3-(4-aminosulfonyl phenyl)thiourea,  was carried out by reaction of 4-methylbenzoyl chloride with potassium thiocyanate in acetone to afford 4-methylbenzoyl isothiocyanate in situ followed by treatment with sulfanilamide. The structure was confirmed byspectroscopic data and elemental analyses. The molecular structure was determined from single crystal X-ray diffraction data. It crystallizes in the monoclinic space group P21/n with unit cell dimensions of a = 4.8116(9) Å, b = 17.150(3) Å, c = 18.677(3) Å, γ = 96.487(4) °, and V = 1531.4(5) Å3.

1_2_73_75_800



Keywords


Thiourea; Sulfonyl thiourea; Single crystal X-ray diffraction

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DOI: 10.5155/eurjchem.1.2.73-75.34

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How to cite


Saeed, A.; Mumtaz, A.; Florke, U. Eur. J. Chem. 2010, 1(2), 73-75. doi:10.5155/eurjchem.1.2.73-75.34
Saeed, A.; Mumtaz, A.; Florke, U. Synthesis, characterization and crystal structure of 1-(4-methylbenzoyl)-3-(4 aminosulfonylphenyl)thiourea. Eur. J. Chem. 2010, 1(2), 73-75. doi:10.5155/eurjchem.1.2.73-75.34
Saeed, A., Mumtaz, A., & Florke, U. (2010). Synthesis, characterization and crystal structure of 1-(4-methylbenzoyl)-3-(4 aminosulfonylphenyl)thiourea. European Journal of Chemistry, 1(2), 73-75. doi:10.5155/eurjchem.1.2.73-75.34
Saeed, Aamer, Amara Mumtaz, & Ulrich Florke. "Synthesis, characterization and crystal structure of 1-(4-methylbenzoyl)-3-(4 aminosulfonylphenyl)thiourea." European Journal of Chemistry [Online], 1.2 (2010): 73-75. Web. 23 Oct. 2019
Saeed, Aamer, Mumtaz, Amara, AND Florke, Ulrich. "Synthesis, characterization and crystal structure of 1-(4-methylbenzoyl)-3-(4 aminosulfonylphenyl)thiourea" European Journal of Chemistry [Online], Volume 1 Number 2 (15 June 2010)

DOI Link: https://doi.org/10.5155/eurjchem.1.2.73-75.34

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