European Journal of Chemistry 2011, 2(4), 514-518 | doi: https://doi.org/10.5155/eurjchem.2.4.514-518.479 | Get rights and content

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Synthesis and reactions of 3-aminotetrachloroquinazolin-2,4-dione


Mamdouh Adly Hassan (1) , Ahmed Mohamed Mosalem Younes (2) , Mohamed Mobark Taha (3) , Abou-Bakr Haredy Abdel-Monsef (4,*)

(1) Chemistry Department, Faculty of Science, South Valley University, Qena-83523, Egypt
(2) Chemistry Department, Faculty of Science, South Valley University, Qena-83523, Egypt
(3) Chemistry Department, Faculty of Science, South Valley University, Qena-83523, Egypt
(4) Chemistry Department, Faculty of Science, South Valley University, Qena-83523, Egypt
(*) Corresponding Author

Received: 21 Jun 2011 | Accepted: 31 Jul 2011 | Published: 31 Dec 2011 | Issue Date: December 2011

Abstract


N-phenylsulphonyloxytetrachlorophthalimide was obtained by treatment of N-hydroxy tetrachlorophthalimide with benzenesulphonyl chloride. Also, the titled compound 3 was obtained by reaction of compound 2 with hydrazine hydrate via Lossen rearrangement. Compound 3 used as starting material for the synthesis of new pyrimidine and quinazolinedione derivatives containing four chlorine atoms which have pharmacological activity.

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Keywords


Quinazolinedione; Hydrazine hydrate; Anti-inflammatory; Tetrachloroquinazolindione; N-Phenylsulphonyloxytetrachlorophthalimide; 3-(N-acetylamino)tetrachloroquinazolindione

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DOI: 10.5155/eurjchem.2.4.514-518.479

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Citations

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[5]. M. A. Hassan, A. M. M. Younes, M. M. Taha, A. Abdel-Monsef
Synthesis and Reactions of 3-(2-Chloromethyl-carbonylamino)tetrachloroquinazolin-2,4-dione
Organic Chemistry International  2012, 1, 2012
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[6]. Mamdouh Adly Hassan, Maghrabi Ali Seleem, Ahmed Mohamed Mosallem Younes, Mohamed Mobark Taha, Abou-Bakr Haredi Abdel-Monsef
Synthesis and spectral characterization of some heterocyclic nitrogen compounds
European Journal of Chemistry  4(2), 121, 2013
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[7]. Aboubakr H. Abdelmonsef, Ahmed M. Mosallam
Synthesis, in vitro biological evaluation and in silico docking studies of new quinazolin‐2,4‐dione analogues as possible anticarcinoma agents
Journal of Heterocyclic Chemistry  57(4), 1637, 2020
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[8]. Aboubakr H. Abdelmonsef, Mohamed A. Abdelhakeem, Ahmed M. Mosallam, Hussain Temairk, Mohamed El‐Naggar, Hend Okasha, Huda R. M. Rashdan
A search for antiinflammatory therapies: Synthesis, in silico investigation of the mode of action, and in vitro analyses of new quinazolin‐2,4‐dione derivatives targeting phosphodiesterase‐4 enzyme
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How to cite


Hassan, M.; Younes, A.; Taha, M.; Abdel-Monsef, A. Eur. J. Chem. 2011, 2(4), 514-518. doi:10.5155/eurjchem.2.4.514-518.479
Hassan, M.; Younes, A.; Taha, M.; Abdel-Monsef, A. Synthesis and reactions of 3-aminotetrachloroquinazolin-2,4-dione. Eur. J. Chem. 2011, 2(4), 514-518. doi:10.5155/eurjchem.2.4.514-518.479
Hassan, M., Younes, A., Taha, M., & Abdel-Monsef, A. (2011). Synthesis and reactions of 3-aminotetrachloroquinazolin-2,4-dione. European Journal of Chemistry, 2(4), 514-518. doi:10.5155/eurjchem.2.4.514-518.479
Hassan, Mamdouh, Ahmed Mohamed Mosalem Younes, Mohamed Mobark Taha, & Abou-Bakr Haredy Abdel-Monsef. "Synthesis and reactions of 3-aminotetrachloroquinazolin-2,4-dione." European Journal of Chemistry [Online], 2.4 (2011): 514-518. Web. 12 Aug. 2022
Hassan, Mamdouh, Younes, Ahmed, Taha, Mohamed, AND Abdel-Monsef, Abou-Bakr. "Synthesis and reactions of 3-aminotetrachloroquinazolin-2,4-dione" European Journal of Chemistry [Online], Volume 2 Number 4 (31 December 2011)

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