European Journal of Chemistry 2011, 2(4), 514-518 | doi: https://doi.org/10.5155/eurjchem.2.4.514-518.479 | Get rights and content

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Synthesis and reactions of 3-aminotetrachloroquinazolin-2,4-dione


Mamdouh Adly Hassan (1) , Ahmed Mohamed Mosalem Younes (2) , Mohamed Mobark Taha (3) , Abou-Bakr Haredy Abdel-Monsef (4,*)

(1) Chemistry Department, Faculty of Science, South Valley University, Qena-83523, Egypt
(2) Chemistry Department, Faculty of Science, South Valley University, Qena-83523, Egypt
(3) Chemistry Department, Faculty of Science, South Valley University, Qena-83523, Egypt
(4) Chemistry Department, Faculty of Science, South Valley University, Qena-83523, Egypt
(*) Corresponding Author

Received: 21 Jun 2011 | Accepted: 31 Jul 2011 | Published: 31 Dec 2011 | Issue Date: December 2011

Abstract


N-phenylsulphonyloxytetrachlorophthalimide was obtained by treatment of N-hydroxy tetrachlorophthalimide with benzenesulphonyl chloride. Also, the titled compound 3 was obtained by reaction of compound 2 with hydrazine hydrate via Lossen rearrangement. Compound 3 used as starting material for the synthesis of new pyrimidine and quinazolinedione derivatives containing four chlorine atoms which have pharmacological activity.

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Keywords


Quinazolinedione; Hydrazine hydrate; Anti-inflammatory; Tetrachloroquinazolindione; N-Phenylsulphonyloxytetrachlorophthalimide; 3-(N-acetylamino)tetrachloroquinazolindione

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DOI: 10.5155/eurjchem.2.4.514-518.479

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Citations

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How to cite


Hassan, M.; Younes, A.; Taha, M.; Abdel-Monsef, A. Eur. J. Chem. 2011, 2(4), 514-518. doi:10.5155/eurjchem.2.4.514-518.479
Hassan, M.; Younes, A.; Taha, M.; Abdel-Monsef, A. Synthesis and reactions of 3-aminotetrachloroquinazolin-2,4-dione. Eur. J. Chem. 2011, 2(4), 514-518. doi:10.5155/eurjchem.2.4.514-518.479
Hassan, M., Younes, A., Taha, M., & Abdel-Monsef, A. (2011). Synthesis and reactions of 3-aminotetrachloroquinazolin-2,4-dione. European Journal of Chemistry, 2(4), 514-518. doi:10.5155/eurjchem.2.4.514-518.479
Hassan, Mamdouh, Ahmed Mohamed Mosalem Younes, Mohamed Mobark Taha, & Abou-Bakr Haredy Abdel-Monsef. "Synthesis and reactions of 3-aminotetrachloroquinazolin-2,4-dione." European Journal of Chemistry [Online], 2.4 (2011): 514-518. Web. 3 Jun. 2023
Hassan, Mamdouh, Younes, Ahmed, Taha, Mohamed, AND Abdel-Monsef, Abou-Bakr. "Synthesis and reactions of 3-aminotetrachloroquinazolin-2,4-dione" European Journal of Chemistry [Online], Volume 2 Number 4 (31 December 2011)

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