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Utility of (2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-acetic acid hydrazide in the synthesis of some heterocyclic nitrogen compounds
Mamdouh Adly Hassan (1)
, Maghrabi Ali Seleem (2) , Ahmed Mohamed Mosallem Younes (3) , Mohamed Mobark Taha (4) , Abou-Bakr Haredi Abdel-Monsef (5,*) (1) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Sinai University, 45518, Arish, Egypt
(2) Chemistry Department, Faculty of Science, South Valley University, Qena, 83523, Egypt
(3) Chemistry Department, Faculty of Science, South Valley University, Qena, 83523, Egypt
(4) Chemistry Department, Faculty of Science, South Valley University, Qena, 83523, Egypt
(5) Chemistry Department, Faculty of Science, South Valley University, Qena, 83523, Egypt
(*) Corresponding Author
Received: 01 Mar 2013 | Accepted: 30 Mar 2013 | Published: 30 Jun 2013 | Issue Date: June 2013
Abstract
An efficient synthesis of (2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-acetic acid hydrazide (3) has been achieved and described. The obtained hydrazide (3) was used in building of some interesting heterocycles such as, triazole, oxadiazole, pyrazole, phthalazine, and indol-2-one rings at position 3. The structures of the obtained compounds were confirmed by IR, 1H NMR, 13C NMR, MS spectral and elemental analysis.
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DOI: 10.5155/eurjchem.4.2.168-171.762
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[4]. Hamdy S. El-Sheshtawy, Aboubakr Haredi Abdelmonsef, Sayed Moustafa Abboudy, Ahmed Mohamed Mosallem Younes, Mohamed Mobark Taha, Mamdouh Adly Hassan
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[5]. Aboubakr H. Abdelmonsef, Mohamed A. Abdelhakeem, Ahmed M. Mosallam, Hussain Temairk, Mohamed El‐Naggar, Hend Okasha, Huda R. M. Rashdan
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[6]. Aboubakr Haredi Abdelmonsef, Mahmoud Eldeeb Mohamed, Mohamed El-Naggar, Hussain Temairk, Ahmed Mohamed Mosallam
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DOI Link: https://doi.org/10.5155/eurjchem.4.2.168-171.762
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European Journal of Chemistry 2013, 4(2), 168-171 | doi: https://doi.org/10.5155/eurjchem.4.2.168-171.762 | Get rights and content
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