European Journal of Chemistry 2013, 4(2), 168-171 | doi: https://doi.org/10.5155/eurjchem.4.2.168-171.762 | Get rights and content

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Utility of (2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-acetic acid hydrazide in the synthesis of some heterocyclic nitrogen compounds


Mamdouh Adly Hassan (1) , Maghrabi Ali Seleem (2) , Ahmed Mohamed Mosallem Younes (3) , Mohamed Mobark Taha (4) , Abou-Bakr Haredi Abdel-Monsef (5,*)

(1) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Sinai University, 45518, Arish, Egypt
(2) Chemistry Department, Faculty of Science, South Valley University, Qena, 83523, Egypt
(3) Chemistry Department, Faculty of Science, South Valley University, Qena, 83523, Egypt
(4) Chemistry Department, Faculty of Science, South Valley University, Qena, 83523, Egypt
(5) Chemistry Department, Faculty of Science, South Valley University, Qena, 83523, Egypt
(*) Corresponding Author

Received: 01 Mar 2013 | Accepted: 30 Mar 2013 | Published: 30 Jun 2013 | Issue Date: June 2013

Abstract


An efficient synthesis of (2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-acetic acid hydrazide (3) has been achieved and described. The obtained hydrazide (3) was used in building of some interesting heterocycles such as, triazole, oxadiazole, pyrazole, phthalazine, and indol-2-one rings at position 3. The structures of the obtained compounds were confirmed by IR, 1H NMR, 13C NMR, MS spectral and elemental analysis.

4_2_168_171

Keywords


Isatine; Acetic acid; Phthalimide; Phenylisothiocyanate; Quinazoline-2,4-dione; Tetrachlorophthalic anhydride

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DOI: 10.5155/eurjchem.4.2.168-171.762

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[1]. Magda I. Marzouk, Soheir A. Shaker, Thoraya A. Farghaly, Maher A. El-Hashash, Shadia M. Hussein
Synthesis of Some Novel Quinazolinone Derivatives with Anticipated Biological Activity
Journal of Heterocyclic Chemistry  54(6), 3331, 2017
DOI: 10.1002/jhet.2953
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[2]. Mohamed El-Naggar, Mahmoud Eldeeb Mohamed, Ahmed Mohamed Mosallam, Wesam Salem, Huda RM Rashdan, Aboubakr Haredi Abdelmonsef
Synthesis, Characterization, Antibacterial Activity, and Computer-Aided Design of Novel Quinazolin-2,4-dione Derivatives as Potential Inhibitors Against Vibrio cholerae
Evolutionary Bioinformatics  16, 117693431989759, 2020
DOI: 10.1177/1176934319897596
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[3]. Bhawana Sharma, Preeti Singh, Ashawani Kumar Singh, Satish K. Awasthi
Advancement of chimeric hybrid drugs to cure malaria infection: An overview with special emphasis on endoperoxide pharmacophores
European Journal of Medicinal Chemistry  219, 113408, 2021
DOI: 10.1016/j.ejmech.2021.113408
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[4]. Hamdy S. El-Sheshtawy, Aboubakr Haredi Abdelmonsef, Sayed Moustafa Abboudy, Ahmed Mohamed Mosallem Younes, Mohamed Mobark Taha, Mamdouh Adly Hassan
Synthesis, Structural, and Theoretical Studies of Quinazoline-2,4-dione Derivatives
Polycyclic Aromatic Compounds  39(3), 279, 2019
DOI: 10.1080/10406638.2017.1325747
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[5]. Aboubakr H. Abdelmonsef, Mohamed A. Abdelhakeem, Ahmed M. Mosallam, Hussain Temairk, Mohamed El‐Naggar, Hend Okasha, Huda R. M. Rashdan
A search for antiinflammatory therapies: Synthesis, in silico investigation of the mode of action, and in vitro analyses of new quinazolin‐2,4‐dione derivatives targeting phosphodiesterase‐4 enzyme
Journal of Heterocyclic Chemistry  , , 2021
DOI: 10.1002/jhet.4395
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[6]. Aboubakr Haredi Abdelmonsef, Mahmoud Eldeeb Mohamed, Mohamed El-Naggar, Hussain Temairk, Ahmed Mohamed Mosallam
Novel Quinazolin-2,4-Dione Hybrid Molecules as Possible Inhibitors Against Malaria: Synthesis and in silico Molecular Docking Studies
Frontiers in Molecular Biosciences  7, , 2020
DOI: 10.3389/fmolb.2020.00105
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How to cite


Hassan, M.; Seleem, M.; Younes, A.; Taha, M.; Abdel-Monsef, A. Eur. J. Chem. 2013, 4(2), 168-171. doi:10.5155/eurjchem.4.2.168-171.762
Hassan, M.; Seleem, M.; Younes, A.; Taha, M.; Abdel-Monsef, A. Utility of (2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-acetic acid hydrazide in the synthesis of some heterocyclic nitrogen compounds. Eur. J. Chem. 2013, 4(2), 168-171. doi:10.5155/eurjchem.4.2.168-171.762
Hassan, M., Seleem, M., Younes, A., Taha, M., & Abdel-Monsef, A. (2013). Utility of (2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-acetic acid hydrazide in the synthesis of some heterocyclic nitrogen compounds. European Journal of Chemistry, 4(2), 168-171. doi:10.5155/eurjchem.4.2.168-171.762
Hassan, Mamdouh, Maghrabi Ali Seleem, Ahmed Mohamed Mosallem Younes, Mohamed Mobark Taha, & Abou-Bakr Haredi Abdel-Monsef. "Utility of (2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-acetic acid hydrazide in the synthesis of some heterocyclic nitrogen compounds." European Journal of Chemistry [Online], 4.2 (2013): 168-171. Web. 24 Jan. 2022
Hassan, Mamdouh, Seleem, Maghrabi, Younes, Ahmed, Taha, Mohamed, AND Abdel-Monsef, Abou-Bakr. "Utility of (2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-acetic acid hydrazide in the synthesis of some heterocyclic nitrogen compounds" European Journal of Chemistry [Online], Volume 4 Number 2 (30 June 2013)

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