

Utility of (2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-acetic acid hydrazide in the synthesis of some heterocyclic nitrogen compounds
Mamdouh Adly Hassan (1)





(1) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Sinai University, 45518, Arish, Egypt
(2) Chemistry Department, Faculty of Science, South Valley University, Qena, 83523, Egypt
(3) Chemistry Department, Faculty of Science, South Valley University, Qena, 83523, Egypt
(4) Chemistry Department, Faculty of Science, South Valley University, Qena, 83523, Egypt
(5) Chemistry Department, Faculty of Science, South Valley University, Qena, 83523, Egypt
(*) Corresponding Author
Received: 01 Mar 2013 | Accepted: 30 Mar 2013 | Published: 30 Jun 2013 | Issue Date: June 2013
Abstract
An efficient synthesis of (2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-acetic acid hydrazide (3) has been achieved and described. The obtained hydrazide (3) was used in building of some interesting heterocycles such as, triazole, oxadiazole, pyrazole, phthalazine, and indol-2-one rings at position 3. The structures of the obtained compounds were confirmed by IR, 1H NMR, 13C NMR, MS spectral and elemental analysis.

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DOI: 10.5155/eurjchem.4.2.168-171.762
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Citations
[1]. Magda I. Marzouk, Soheir A. Shaker, Thoraya A. Farghaly, Maher A. El-Hashash, Shadia M. Hussein
Synthesis of Some Novel Quinazolinone Derivatives with Anticipated Biological Activity
Journal of Heterocyclic Chemistry 54(6), 3331, 2017
DOI: 10.1002/jhet.2953

[2]. Mohamed El-Naggar, Mahmoud Eldeeb Mohamed, Ahmed Mohamed Mosallam, Wesam Salem, Huda RM Rashdan, Aboubakr Haredi Abdelmonsef
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Evolutionary Bioinformatics 16, 117693431989759, 2020
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[3]. Bhawana Sharma, Preeti Singh, Ashawani Kumar Singh, Satish K. Awasthi
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European Journal of Medicinal Chemistry , 113408, 2021
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[4]. Hamdy S. El-Sheshtawy, Aboubakr Haredi Abdelmonsef, Sayed Moustafa Abboudy, Ahmed Mohamed Mosallem Younes, Mohamed Mobark Taha, Mamdouh Adly Hassan
Synthesis, Structural, and Theoretical Studies of Quinazoline-2,4-dione Derivatives
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DOI: 10.1080/10406638.2017.1325747

[5]. Aboubakr Haredi Abdelmonsef, Mahmoud Eldeeb Mohamed, Mohamed El-Naggar, Hussain Temairk, Ahmed Mohamed Mosallam
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DOI: 10.3389/fmolb.2020.00105

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