European Journal of Chemistry

Utility of (2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-acetic acid hydrazide in the synthesis of some heterocyclic nitrogen compounds

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Mamdouh Adly Hassan
Maghrabi Ali Seleem
Ahmed Mohamed Mosallem Younes
Mohamed Mobark Taha
Abou-Bakr Haredi Abdel-Monsef


An efficient synthesis of (2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-acetic acid hydrazide (3) has been achieved and described. The obtained hydrazide (3) was used in building of some interesting heterocycles such as, triazole, oxadiazole, pyrazole, phthalazine, and indol-2-one rings at position 3. The structures of the obtained compounds were confirmed by IR, 1H NMR, 13C NMR, MS spectral and elemental analysis.


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Hassan, M. A.; Seleem, M. A.; Younes, A. M. M.; Taha, M. M.; Abdel-Monsef, A.-B. H. Utility of (2,4-Dioxo-1,4-Dihydro-2H-Quinazolin-3-Yl)-Acetic Acid Hydrazide in the Synthesis of Some Heterocyclic Nitrogen Compounds. Eur. J. Chem. 2013, 4, 168-171.

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