

A novel method for tizanidine hydrochloride determination in aqueous solution based on fluorescence quenching of functionalised CdS quantum dots as luminescent probes
Marwa Ahmed Fouad (1,*)


(1) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo-11562, Egypt
(2) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo-11562, Egypt
(*) Corresponding Author
Received: 14 Jul 2011 | Revised: 19 Aug 2011 | Accepted: 21 Aug 2011 | Published: 31 Mar 2012 | Issue Date: March 2012
Abstract
A novel, sensitive and convenient method for the determination of tizanidine hydrochloride (TZD) based on the fluorescence quenching of thioglycolic acid-capped CdS quantum dots (TGA-CdS QDs) is proposed. Luminescent CdS semiconductor quantum dots modified by thioglycolic acid were synthesized from cadmium nitrate and sodium sulfide in alkaline aqueous solution. The modified CdS QDs are water-soluble, stable and highly luminescent. When TZD was added into the CdS QDs colloidal solution, the surface of CdS QDs generates the electrostatic interaction in aqueous medium, which induces the quenching of fluorescence emission at 518 nm upon excitation at 340 nm. Under the optimal conditions, the Stern-Volmer calibration plot of Fο/F against concentration of TZD was linear in the range of 3.0-18.0 μg/mL with a correlation coefficient of 0.9953. The detection limit was 1.35 μg/mL. The relative standard deviation for five determinations of 9 μg/mL TZD was 2.29%. The proposed method was successfully applied to commercial tablets with satisfactory results. The results were found to be in good agreement with those obtained by the reference method. The possible fluorescence quenching mechanism for the reaction is also discussed.
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DOI: 10.5155/eurjchem.3.1.40-43.485
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Citations
[1]. J. Shah, M. Rasul Jan, Tasmia, M. Yousaf
Cadmium Sulfide Quantum Dots as a Fluorescent Probe for Quantitative Determination of Cefixime
Journal of Applied Spectroscopy 83(2), 248, 2016
DOI: 10.1007/s10812-016-0277-2

[2]. Laxmi S. Killedar, Mahesh M. Shanbhag, Shweta J. Malode, Gangadhar B. Bagihalli, Supratim Mahapatra, Ronald J. Mascarenhas, Nagaraj P. Shetti, Pranjal Chandra
Ultra-sensitive detection of tizanidine in commercial tablets and urine samples using zinc oxide coated glassy carbon electrode
Microchemical Journal 172, 106956, 2022
DOI: 10.1016/j.microc.2021.106956

[3]. Ramzia Ismail El-Bagary, Asmaa Ahmed El-Zaher, Ehab Farouk Elkady, Asmaa Abdelkerim Mandour
A novel method for determination of tinidazole and metronidazole in aqueous solutions based on fluorescence quenching of functionalized CdS quantum dots as luminescent probes
Future Journal of Pharmaceutical Sciences 4(2), 185, 2018
DOI: 10.1016/j.fjps.2018.03.003

References
[1]. Kaul, N.; Dhaneshwar, S. R.; Agrawal, H.; Kakad, A.; Patil, B. J. Pharm. Biomed. Anal. 2005, 37, 27-38.
http://dx.doi.org/10.1016/j.jpba.2004.09.036
PMid:15664740
[2]. Sujatha, K.; Chitra, K.; Hettiarachchi, D. S.; Krishna, V. M.; Vasantha, J. Indian J. Pharm. Sci. 2003, 65, 519-520.
[3]. Shankar, M. B.; Shah, D. A.; Geetha, M.; Mehta, F. A.; Mehta, R. S.; Bhatt, K. K. Indian J. Pharm. Sci. 2004, 66, 332-336.
[4]. Lee, J.; Seo, J. H.; Kim, D. H. Analyst 2002, 127, 917-920.
http://dx.doi.org/10.1039/b202271k
PMid:12173650
[5]. Mahadik, K. R.; Paradkar, A. R.; Agrawal, H.; Kaul, N. J. Pharm. Biomed. Anal. 2003, 33, 545-552.
http://dx.doi.org/10.1016/S0731-7085(03)00304-2
[6]. Qi, M.; Wang, P.; Wang, L. Anal. Chim. Acta. 2003, 478, 171-177.
http://dx.doi.org/10.1016/S0003-2670(02)01525-8
[7]. Gandhimathi, M.; Ravi, T. K.; Varghese, S. J. J. Pharm. Biomed. Anal. 2005, 37, 183-185.
http://dx.doi.org/10.1016/j.jpba.2004.09.039
PMid:15664760
[8]. Battu, P. R. Int. J. ChemTech Res. 2009, 1, 499-501.
[9]. Healzlewood, V.; Symoniw, P.; Maruff, P.; Eadie, M. J. Eur. J. Clin. Pharmacol. 1983, 25, 65-72.
http://dx.doi.org/10.1007/BF00544016
PMid:6617726
[10]. Peng, J.; Hu, X. J. Lumin. 2011, 131, 952-955.
http://dx.doi.org/10.1016/j.jlumin.2010.12.030
[11]. Gore, A. H.; Mote, U. S.; Tele, S. S.; Anbhule, P. V.; Rath, M. C.; Patil, S. R.; Kolekar, G. B. Analyst 2011, 136, 2606-2612.
http://dx.doi.org/10.1039/c0an01038c
PMid:21519628
[12]. Dong, F.; Hu, K.; Han, H.; Liang. J. Microchim. Acta 2009, 165, 195-201.
http://dx.doi.org/10.1007/s00604-008-0120-4
[13]. Winter, J. O.; Gomez, N.; Gatzert, S.; Schmidt, C. E.; Korgel, B. A. Colloids Surf. A: Physicochem. Eng. Aspects. 2005, 254, 147-157.
http://dx.doi.org/10.1016/j.colsurfa.2004.11.024
[14]. Liu, M.; Xu, L.; Cheng, W.; Zeng, Y.; Yan, Z. Spectrochim. Acta Part A 2008, 70, 1198-1202.
http://dx.doi.org/10.1016/j.saa.2007.10.040
PMid:18201928
[15]. Liang, J. G.; Huang, S.; Zeng, D. Y.; He, Z. K.; Ji, X. H.; Ai, X. P.; Yang, X. H. Talanta 2006, 69, 126-130.
http://dx.doi.org/10.1016/j.talanta.2005.09.004
PMid:18970543
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DOI Link: https://doi.org/10.5155/eurjchem.3.1.40-43.485

















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