European Journal of Chemistry 2012, 3(1), 40-43. doi:10.5155/eurjchem.3.1.40-43.485

A novel method for tizanidine hydrochloride determination in aqueous solution based on fluorescence quenching of functionalised CdS quantum dots as luminescent probes


Marwa Ahmed Fouad (1,*) , Ehab Farouk Elkady (2)

(1) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo-11562, Egypt
(2) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo-11562, Egypt
(*) Corresponding Author

Received: 14 Jul 2011, Accepted: 21 Aug 2011, Published: 31 Mar 2012

Abstract


A novel, sensitive and convenient method for the determination of tizanidine hydrochloride (TZD) based on the fluorescence quenching of thioglycolic acid-capped CdS quantum dots (TGA-CdS QDs) is proposed. Luminescent CdS semiconductor quantum dots modified by thioglycolic acid were synthesized from cadmium nitrate and sodium sulfide in alkaline aqueous solution. The modified CdS QDs are water-soluble, stable and highly luminescent. When TZD was added into the CdS QDs colloidal solution, the surface of CdS QDs generates the electrostatic interaction in aqueous medium, which induces the quenching of fluorescence emission at 518 nm upon excitation at 340 nm. Under the optimal conditions, the Stern-Volmer calibration plot of F­ο/F against concentration of TZD was linear in the range of 3.0-18.0 μg/mL with a correlation coefficient of 0.9953. The detection limit was 1.35 μg/mL. The relative standard deviation for five determinations of 9 μg/mL TZD was 2.29%. The proposed method was successfully applied to commercial tablets with satisfactory results. The results were found to be in good agreement with those obtained by the reference method. The possible fluorescence quenching mechanism for the reaction is also discussed.

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Keywords


Quantum dots; Determination; Nanotechnology; Fluorescence quenching; Tizanidine hydrochloride; Pharmaceutical preparation

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DOI: 10.5155/eurjchem.3.1.40-43.485

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Citations

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[1]. J. Shah, M. Rasul Jan, Tasmia, M. Yousaf
Cadmium Sulfide Quantum Dots as a Fluorescent Probe for Quantitative Determination of Cefixime
Journal of Applied Spectroscopy  83(2), 248, 2016
DOI: 10.1007/s10812-016-0277-2
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[2]. Ramzia Ismail El-Bagary, Asmaa Ahmed El-Zaher, Ehab Farouk Elkady, Asmaa Abdelkerim Mandour
A novel method for determination of tinidazole and metronidazole in aqueous solutions based on fluorescence quenching of functionalized CdS quantum dots as luminescent probes
Future Journal of Pharmaceutical Sciences  4(2), 185, 2018
DOI: 10.1016/j.fjps.2018.03.003
/


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How to cite


Fouad, M.; Elkady, E. Eur. J. Chem. 2012, 3(1), 40-43. doi:10.5155/eurjchem.3.1.40-43.485
Fouad, M.; Elkady, E. A novel method for tizanidine hydrochloride determination in aqueous solution based on fluorescence quenching of functionalised CdS quantum dots as luminescent probes. Eur. J. Chem. 2012, 3(1), 40-43. doi:10.5155/eurjchem.3.1.40-43.485
Fouad, M., & Elkady, E. (2012). A novel method for tizanidine hydrochloride determination in aqueous solution based on fluorescence quenching of functionalised CdS quantum dots as luminescent probes. European Journal of Chemistry, 3(1), 40-43. doi:10.5155/eurjchem.3.1.40-43.485
Fouad, Marwa, & Ehab Farouk Elkady. "A novel method for tizanidine hydrochloride determination in aqueous solution based on fluorescence quenching of functionalised CdS quantum dots as luminescent probes." European Journal of Chemistry [Online], 3.1 (2012): 40-43. Web. 17 Sep. 2019
Fouad, Marwa, AND Elkady, Ehab. "A novel method for tizanidine hydrochloride determination in aqueous solution based on fluorescence quenching of functionalised CdS quantum dots as luminescent probes" European Journal of Chemistry [Online], Volume 3 Number 1 (31 March 2012)

DOI Link: https://doi.org/10.5155/eurjchem.3.1.40-43.485

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