European Journal of Chemistry

Spectrofluorometric determination of linagliptin in bulk and in pharmaceutical dosage form

Article Sidebar

PDF
Published: Jun 30, 2014
DOI: https://doi.org/10.5155/eurjchem.5.2.380-382.845
Keywords:
Tradjenta, Linagliptin, Fluorometry, DPP-4 Inhibitors, Statistical analysis, Pharmaceutical preparation
Section
Short Communication
Issue
Vol. 5 No. 2 (2014): June 2014
Dates
Received 2013-06-04
Accepted 2013-08-18
Published 2014-06-30


Main Article Content

Ramzia Ismail El-Bagary
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
Ehab Farouk Elkady
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
Bassam Mahfouz Ayoub
Pharmaceutical Chemistry Department, Faculty of Pharmacy, British University in Egypt, El-Sherouk City, Cairo 11837, Egypt

Abstract

Simple and precise spectrofluorometric method has been developed and validated for the determination of linagliptin (LNG) in the range of 10-110 μg/mL. The results obtained were of good precision and statistically compared to the reference method using one-way analysis of variance (ANOVA). The method developed was satisfactorily applied to the analysis of the pharmaceutical formulation and proved to be specific and accurate for the quality control of linagliptin in its pharmaceutical dosage form. The development of spectrofluorometric method for the determination of LNG was of interest as no such methods have been reported.


icon graph This Abstract was viewed 1934 times | icon graph Article PDF downloaded 974 times

How to Cite
(1)
El-Bagary, R. I.; Elkady, E. F.; Ayoub, B. M. Spectrofluorometric Determination of Linagliptin in Bulk and in Pharmaceutical Dosage Form. Eur. J. Chem. 2014, 5, 380-382.

Article Details

Share
Links for Article


Crossref - Scopus - Google - European PMC
Crossref
Scopus
Google Scholar
Europe PMC
References

[1] Kirby, M.; Yu, D.; Conor, S. Clin. Sci. 2010, 118, 31-41.
http://dx.doi.org/10.1042/CS20090047

[2] Sekaran, B.; Rani, P. Int. J. Pharm. Pharm. Sci. 2010, 2, 138-142.

[3] Lakshmi, B.; Reddy, T. J. Atom. Mol. 2012, 2, 155-164.

[4] El-Ashry, S.; El-Sherbeny, M.; El-Sherbeny, D. J. Pharm. Biomed. Anal. 2000, 22, 729-737.
http://dx.doi.org/10.1016/S0731-7085(99)00267-8

[5] Rizk, M.; Belal, F.; Ibrahim, F. Pharm. Acta Helv. 2000, 74, 371-377.
http://dx.doi.org/10.1016/S0031-6865(00)00025-X

[6] Belal, F.; Ibrahim, F.; Hassan, S. Anal. Chim. Acta 1991, 255, 103-106.
http://dx.doi.org/10.1016/0003-2670(91)85093-8

[7] Bebawy, L.; Abbas, S.; Fattah, L.; Refaat, H. Il Farmaco 2005, 60, 859-867.
http://dx.doi.org/10.1016/j.farmac.2005.06.009

Supporting Agencies

Most read articles by the same author(s)

Most read articles by the same author(s)

TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2025 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).