European Journal of Chemistry 2014, 5(2), 380-382 | doi: https://doi.org/10.5155/eurjchem.5.2.380-382.845 | Get rights and content

Issue cover





  Open Access OPEN ACCESS | Open Access PEER-REVIEWED | SHORT COMMUNICATION | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS

Spectrofluorometric determination of linagliptin in bulk and in pharmaceutical dosage form


Ramzia Ismail El-Bagary (1) , Ehab Farouk Elkady (2) , Bassam Mahfouz Ayoub (3,*)

(1) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
(2) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
(3) Pharmaceutical Chemistry Department, Faculty of Pharmacy, British University in Egypt, El-Sherouk City, Cairo 11837, Egypt
(*) Corresponding Author

Received: 04 Jun 2013 | Revised: 26 Jul 2013 | Accepted: 18 Aug 2013 | Published: 30 Jun 2014 | Issue Date: June 2014

Abstract


Simple and precise spectrofluorometric method has been developed and validated for the determination of linagliptin (LNG) in the range of 10-110 μg/mL. The results obtained were of good precision and statistically compared to the reference method using one-way analysis of variance (ANOVA). The method developed was satisfactorily applied to the analysis of the pharmaceutical formulation and proved to be specific and accurate for the quality control of linagliptin in its pharmaceutical dosage form. The development of spectrofluorometric method for the determination of LNG was of interest as no such methods have been reported.


Keywords


Tradjenta; Linagliptin; Fluorometry; DPP-4 Inhibitors; Statistical analysis; Pharmaceutical preparation

Full Text:

PDF
PDF    Open Access

DOI: 10.5155/eurjchem.5.2.380-382.845

Links for Article


| | | | | | |

| | | | | | |

| | |

Related Articles




Article Metrics

icon graph This Abstract was viewed 887 times | icon graph PDF Article downloaded 347 times


Citations

/


[1]. Mohamed Rizk, Ali K. Attia, Heba Y. Mohamed, Mona S. Elshahed
Validated Voltammetric Method for the Simultaneous Determination of Anti‐diabetic Drugs, Linagliptin and Empagliflozin in Bulk, Pharmaceutical Dosage Forms and Biological Fluids
Electroanalysis  32(8), 1737, 2020
DOI: 10.1002/elan.202000007
/

[2]. Ahmed. H. NAGGAR, Gamal. A. SALEH, Mahmoud. A. OMAR, Ahmed. M. HAREDY, Sayed. M. DERAYEA
Square-wave Adsorptive Anodic Stripping Voltammetric Determination of Antidiabetic Drug Linagliptin in Pharmaceutical Formulations and Biological Fluids Using a Pencil Graphite Electrode
Analytical Sciences  36(9), 1031, 2020
DOI: 10.2116/analsci.19P469
/

[3]. H.N. Deepakumari, B. Shyla, H.D. Revanasiddappa
Hypoglycemic Agents: Micro-Determination by Highly Sensitive and Validated Spectrophotometric Techniques
Analytical Chemistry Letters  8(2), 152, 2018
DOI: 10.1080/22297928.2018.1456360
/

[4]. Mahmoud A. Omar, Ahmed M. Haredy, Gamal A. Saleh, A.H. Naggar, Sayed M. Derayea
Diarylpyrrolone based fluorophore for the selective spectrofluorometric method for determination of Linagliptin antidiabetic drug in pharmaceutical tablets
Microchemical Journal  148, 555, 2019
DOI: 10.1016/j.microc.2019.05.046
/

[5]. Heba A. Aref, Sherin F. Hammad, Mohamed Saleh Elgawish, Khaled M. Darwish
Novel spectrofluorimetric quantification of linagliptin in biological fluids exploiting its interaction with 4‐chloro‐7‐nitrobenzofurazan
Luminescence  35(5), 626, 2020
DOI: 10.1002/bio.3767
/

[6]. Manal S. Elmasry, Mohamed A. Hasan, Wafaa S. Hassan, Hanan A. Merey, Israa M. Nour
Flourimetric study on antidiabetic combined drugs; empagliflozin and linagliptin in their pharmaceutical formulation and human plasma
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy  248, 119258, 2021
DOI: 10.1016/j.saa.2020.119258
/

References


[1] Kirby, M.; Yu, D.; Conor, S. Clin. Sci. 2010, 118, 31-41.
http://dx.doi.org/10.1042/CS20090047

[2] Sekaran, B.; Rani, P. Int. J. Pharm. Pharm. Sci. 2010, 2, 138-142.

[3] Lakshmi, B.; Reddy, T. J. Atom. Mol. 2012, 2, 155-164.

[4] El-Ashry, S.; El-Sherbeny, M.; El-Sherbeny, D. J. Pharm. Biomed. Anal. 2000, 22, 729-737.
http://dx.doi.org/10.1016/S0731-7085(99)00267-8

[5] Rizk, M.; Belal, F.; Ibrahim, F. Pharm. Acta Helv. 2000, 74, 371-377.
http://dx.doi.org/10.1016/S0031-6865(00)00025-X

[6] Belal, F.; Ibrahim, F.; Hassan, S. Anal. Chim. Acta 1991, 255, 103-106.
http://dx.doi.org/10.1016/0003-2670(91)85093-8

[7] Bebawy, L.; Abbas, S.; Fattah, L.; Refaat, H. Il Farmaco 2005, 60, 859-867.
http://dx.doi.org/10.1016/j.farmac.2005.06.009


How to cite


El-Bagary, R.; Elkady, E.; Ayoub, B. Eur. J. Chem. 2014, 5(2), 380-382. doi:10.5155/eurjchem.5.2.380-382.845
El-Bagary, R.; Elkady, E.; Ayoub, B. Spectrofluorometric determination of linagliptin in bulk and in pharmaceutical dosage form. Eur. J. Chem. 2014, 5(2), 380-382. doi:10.5155/eurjchem.5.2.380-382.845
El-Bagary, R., Elkady, E., & Ayoub, B. (2014). Spectrofluorometric determination of linagliptin in bulk and in pharmaceutical dosage form. European Journal of Chemistry, 5(2), 380-382. doi:10.5155/eurjchem.5.2.380-382.845
El-Bagary, Ramzia, Ehab Farouk Elkady, & Bassam Mahfouz Ayoub. "Spectrofluorometric determination of linagliptin in bulk and in pharmaceutical dosage form." European Journal of Chemistry [Online], 5.2 (2014): 380-382. Web. 2 Mar. 2021
El-Bagary, Ramzia, Elkady, Ehab, AND Ayoub, Bassam. "Spectrofluorometric determination of linagliptin in bulk and in pharmaceutical dosage form" European Journal of Chemistry [Online], Volume 5 Number 2 (30 June 2014)

The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item



DOI Link: https://doi.org/10.5155/eurjchem.5.2.380-382.845

CrossRef | Scilit | GrowKudos | Researchgate | Publons | Microsoft | scibey | Scite | Lens | OUCI

WorldCat Paperbuzz Citeas | Dimensions | Semanticscholar | Plumx | Kopernio | Zotero | Mendeley

ZoteroSave to Zotero MendeleySave to Mendeley



European Journal of Chemistry 2014, 5(2), 380-382 | doi: https://doi.org/10.5155/eurjchem.5.2.380-382.845 | Get rights and content

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c)




© Copyright 2010 - 2021 • Atlanta Publishing House LLC • All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2010-2021 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.