European Journal of Chemistry

Spectrofluorometric determination of linagliptin in bulk and in pharmaceutical dosage form

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Published: Jun 30, 2014
DOI: https://doi.org/10.5155/eurjchem.5.2.380-382.845
Keywords:
Tradjenta, Linagliptin, Fluorometry, DPP-4 Inhibitors, Statistical analysis, Pharmaceutical preparation
Section
Short Communication
Issue
Vol. 5 No. 2 (2014): June 2014
Dates
Received 2013-06-04
Accepted 2013-08-18
Published 2014-06-30


Main Article Content

Ramzia Ismail El-Bagary
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
Ehab Farouk Elkady
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
Bassam Mahfouz Ayoub
Pharmaceutical Chemistry Department, Faculty of Pharmacy, British University in Egypt, El-Sherouk City, Cairo 11837, Egypt

Abstract

Simple and precise spectrofluorometric method has been developed and validated for the determination of linagliptin (LNG) in the range of 10-110 μg/mL. The results obtained were of good precision and statistically compared to the reference method using one-way analysis of variance (ANOVA). The method developed was satisfactorily applied to the analysis of the pharmaceutical formulation and proved to be specific and accurate for the quality control of linagliptin in its pharmaceutical dosage form. The development of spectrofluorometric method for the determination of LNG was of interest as no such methods have been reported.


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How to Cite
(1)
El-Bagary, R. I.; Elkady, E. F.; Ayoub, B. M. Spectrofluorometric Determination of Linagliptin in Bulk and in Pharmaceutical Dosage Form. Eur. J. Chem. 2014, 5, 380-382.

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