

Spectrofluorometric determination of linagliptin in bulk and in pharmaceutical dosage form
Ramzia Ismail El-Bagary (1)



(1) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
(2) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
(3) Pharmaceutical Chemistry Department, Faculty of Pharmacy, British University in Egypt, El-Sherouk City, Cairo 11837, Egypt
(*) Corresponding Author
Received: 04 Jun 2013 | Revised: 26 Jul 2013 | Accepted: 18 Aug 2013 | Published: 30 Jun 2014 | Issue Date: June 2014
Abstract
Simple and precise spectrofluorometric method has been developed and validated for the determination of linagliptin (LNG) in the range of 10-110 μg/mL. The results obtained were of good precision and statistically compared to the reference method using one-way analysis of variance (ANOVA). The method developed was satisfactorily applied to the analysis of the pharmaceutical formulation and proved to be specific and accurate for the quality control of linagliptin in its pharmaceutical dosage form. The development of spectrofluorometric method for the determination of LNG was of interest as no such methods have been reported.
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DOI: 10.5155/eurjchem.5.2.380-382.845
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Citations
[1]. Mohamed Rizk, Ali K. Attia, Heba Y. Mohamed, Mona S. Elshahed
Validated Voltammetric Method for the Simultaneous Determination of Anti‐diabetic Drugs, Linagliptin and Empagliflozin in Bulk, Pharmaceutical Dosage Forms and Biological Fluids
Electroanalysis 32(8), 1737, 2020
DOI: 10.1002/elan.202000007

[2]. Ahmed. H. NAGGAR, Gamal. A. SALEH, Mahmoud. A. OMAR, Ahmed. M. HAREDY, Sayed. M. DERAYEA
Square-wave Adsorptive Anodic Stripping Voltammetric Determination of Antidiabetic Drug Linagliptin in Pharmaceutical Formulations and Biological Fluids Using a Pencil Graphite Electrode
Analytical Sciences 36(9), 1031, 2020
DOI: 10.2116/analsci.19P469

[3]. H.N. Deepakumari, B. Shyla, H.D. Revanasiddappa
Hypoglycemic Agents: Micro-Determination by Highly Sensitive and Validated Spectrophotometric Techniques
Analytical Chemistry Letters 8(2), 152, 2018
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[4]. Mahmoud A. Omar, Ahmed M. Haredy, Gamal A. Saleh, A.H. Naggar, Sayed M. Derayea
Diarylpyrrolone based fluorophore for the selective spectrofluorometric method for determination of Linagliptin antidiabetic drug in pharmaceutical tablets
Microchemical Journal 148, 555, 2019
DOI: 10.1016/j.microc.2019.05.046

[5]. Heba A. Aref, Sherin F. Hammad, Mohamed Saleh Elgawish, Khaled M. Darwish
Novel spectrofluorimetric quantification of linagliptin in biological fluids exploiting its interaction with 4‐chloro‐7‐nitrobenzofurazan
Luminescence 35(5), 626, 2020
DOI: 10.1002/bio.3767

[6]. Manal S. Elmasry, Mohamed A. Hasan, Wafaa S. Hassan, Hanan A. Merey, Israa M. Nour
Flourimetric study on antidiabetic combined drugs; empagliflozin and linagliptin in their pharmaceutical formulation and human plasma
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 248, 119258, 2021
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DOI Link: https://doi.org/10.5155/eurjchem.5.2.380-382.845

















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