Email this article 
Hide
Show all
OPEN ACCESS | 
PEER-REVIEWED |
SHORT COMMUNICATION
|
DOWNLOAD PDF
|
VIEW FULL-TEXT PDF
| TOTAL VIEWS
Spectrofluorometric determination of linagliptin in bulk and in pharmaceutical dosage form
Ramzia Ismail El-Bagary (1)
, Ehab Farouk Elkady (2) , Bassam Mahfouz Ayoub (3,*) (1) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
(2) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
(3) Pharmaceutical Chemistry Department, Faculty of Pharmacy, British University in Egypt, El-Sherouk City, Cairo 11837, Egypt
(*) Corresponding Author
Received: 04 Jun 2013 | Revised: 26 Jul 2013 | Accepted: 18 Aug 2013 | Published: 30 Jun 2014 | Issue Date: June 2014
Abstract
Simple and precise spectrofluorometric method has been developed and validated for the determination of linagliptin (LNG) in the range of 10-110 μg/mL. The results obtained were of good precision and statistically compared to the reference method using one-way analysis of variance (ANOVA). The method developed was satisfactorily applied to the analysis of the pharmaceutical formulation and proved to be specific and accurate for the quality control of linagliptin in its pharmaceutical dosage form. The development of spectrofluorometric method for the determination of LNG was of interest as no such methods have been reported.
Keywords
Full Text:
PDF
DOI: 10.5155/eurjchem.5.2.380-382.845
Links for Article
| | | | | | |
| | | | | | |
| | |
Related Articles
Article Metrics
This Abstract was viewed 917 times |
PDF Article downloaded 357 times
Citations
[1]. Mohamed Rizk, Ali K. Attia, Heba Y. Mohamed, Mona S. Elshahed
Validated Voltammetric Method for the Simultaneous Determination of Anti‐diabetic Drugs, Linagliptin and Empagliflozin in Bulk, Pharmaceutical Dosage Forms and Biological Fluids
Electroanalysis 32(8), 1737, 2020
DOI: 10.1002/elan.202000007
[2]. Ahmed. H. NAGGAR, Gamal. A. SALEH, Mahmoud. A. OMAR, Ahmed. M. HAREDY, Sayed. M. DERAYEA
Square-wave Adsorptive Anodic Stripping Voltammetric Determination of Antidiabetic Drug Linagliptin in Pharmaceutical Formulations and Biological Fluids Using a Pencil Graphite Electrode
Analytical Sciences 36(9), 1031, 2020
DOI: 10.2116/analsci.19P469
[3]. Mohammad Reza Baezzat, Fatemeh Shojaei
Electrochemical sensor based on GCE modified with E-rGO/Poly (B-CD)/magnetic ZIF-67 nanocomposite for the measurement of Linagliptin
Diamond and Related Materials 114, 108345, 2021
DOI: 10.1016/j.diamond.2021.108345
[4]. H.N. Deepakumari, B. Shyla, H.D. Revanasiddappa
Hypoglycemic Agents: Micro-Determination by Highly Sensitive and Validated Spectrophotometric Techniques
Analytical Chemistry Letters 8(2), 152, 2018
DOI: 10.1080/22297928.2018.1456360
[5]. Mahmoud A. Omar, Ahmed M. Haredy, Gamal A. Saleh, A.H. Naggar, Sayed M. Derayea
Diarylpyrrolone based fluorophore for the selective spectrofluorometric method for determination of Linagliptin antidiabetic drug in pharmaceutical tablets
Microchemical Journal 148, 555, 2019
DOI: 10.1016/j.microc.2019.05.046
[6]. Heba A. Aref, Sherin F. Hammad, Mohamed Saleh Elgawish, Khaled M. Darwish
Novel spectrofluorimetric quantification of linagliptin in biological fluids exploiting its interaction with 4‐chloro‐7‐nitrobenzofurazan
Luminescence 35(5), 626, 2020
DOI: 10.1002/bio.3767
[7]. Noha S. Abbas, Sayed M. Derayea, Mahmoud A. Omar, Gamal A. Saleh
Innovative TLC-densitometric method with fluorescent detection for simultaneous determination of ternary anti-diabetic mixture in pharmaceutical formulations and human plasma
Microchemical Journal 165, 106131, 2021
DOI: 10.1016/j.microc.2021.106131
[8]. Manal S. Elmasry, Mohamed A. Hasan, Wafaa S. Hassan, Hanan A. Merey, Israa M. Nour
Flourimetric study on antidiabetic combined drugs; empagliflozin and linagliptin in their pharmaceutical formulation and human plasma
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 248, 119258, 2021
DOI: 10.1016/j.saa.2020.119258
References
[1] Kirby, M.; Yu, D.; Conor, S. Clin. Sci. 2010, 118, 31-41.
http://dx.doi.org/10.1042/CS20090047
[2] Sekaran, B.; Rani, P. Int. J. Pharm. Pharm. Sci. 2010, 2, 138-142.
[3] Lakshmi, B.; Reddy, T. J. Atom. Mol. 2012, 2, 155-164.
[4] El-Ashry, S.; El-Sherbeny, M.; El-Sherbeny, D. J. Pharm. Biomed. Anal. 2000, 22, 729-737.
http://dx.doi.org/10.1016/S0731-7085(99)00267-8
[5] Rizk, M.; Belal, F.; Ibrahim, F. Pharm. Acta Helv. 2000, 74, 371-377.
http://dx.doi.org/10.1016/S0031-6865(00)00025-X
[6] Belal, F.; Ibrahim, F.; Hassan, S. Anal. Chim. Acta 1991, 255, 103-106.
http://dx.doi.org/10.1016/0003-2670(91)85093-8
[7] Bebawy, L.; Abbas, S.; Fattah, L.; Refaat, H. Il Farmaco 2005, 60, 859-867.
http://dx.doi.org/10.1016/j.farmac.2005.06.009
How to cite
The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item
DOI Link: https://doi.org/10.5155/eurjchem.5.2.380-382.845
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
Save to Zotero
Save to Mendeley
European Journal of Chemistry 2014, 5(2), 380-382 | doi: https://doi.org/10.5155/eurjchem.5.2.380-382.845 | Get rights and content
Refbacks
- There are currently no refbacks.
Copyright (c)
© Copyright 2010 - 2021 • Atlanta Publishing House LLC • All Right Reserved.
The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.
Copyright 2010-2021 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.