European Journal of Chemistry 2014, 5(2), 380-382 | doi: https://doi.org/10.5155/eurjchem.5.2.380-382.845 | Get rights and content

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Spectrofluorometric determination of linagliptin in bulk and in pharmaceutical dosage form


Ramzia Ismail El-Bagary (1) , Ehab Farouk Elkady (2) , Bassam Mahfouz Ayoub (3,*)

(1) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
(2) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
(3) Pharmaceutical Chemistry Department, Faculty of Pharmacy, British University in Egypt, El-Sherouk City, Cairo 11837, Egypt
(*) Corresponding Author

Received: 04 Jun 2013 | Revised: 26 Jul 2013 | Accepted: 18 Aug 2013 | Published: 30 Jun 2014 | Issue Date: June 2014

Abstract


Simple and precise spectrofluorometric method has been developed and validated for the determination of linagliptin (LNG) in the range of 10-110 μg/mL. The results obtained were of good precision and statistically compared to the reference method using one-way analysis of variance (ANOVA). The method developed was satisfactorily applied to the analysis of the pharmaceutical formulation and proved to be specific and accurate for the quality control of linagliptin in its pharmaceutical dosage form. The development of spectrofluorometric method for the determination of LNG was of interest as no such methods have been reported.


Keywords


Tradjenta; Linagliptin; Fluorometry; DPP-4 Inhibitors; Statistical analysis; Pharmaceutical preparation

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DOI: 10.5155/eurjchem.5.2.380-382.845

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Citations

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[1]. Mohamed Rizk, Ali K. Attia, Heba Y. Mohamed, Mona S. Elshahed
Validated Voltammetric Method for the Simultaneous Determination of Anti‐diabetic Drugs, Linagliptin and Empagliflozin in Bulk, Pharmaceutical Dosage Forms and Biological Fluids
Electroanalysis  32(8), 1737, 2020
DOI: 10.1002/elan.202000007
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[2]. Ramji Rathod, Faraat Ali, Amrish Chandra, Robin Kumar, Meenakshi Dahiya, Gyanendra Nath Singh
Simultaneous Determination of Alogliptin, Linagliptin, Saxagliptin, and Sitagliptin in Bulk Drug and Formulation by UPLC Q-TOF-MS
Current Pharmaceutical Analysis  17(1), 95, 2020
DOI: 10.2174/1573412915666190708162012
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[3]. Ahmed. H. NAGGAR, Gamal. A. SALEH, Mahmoud. A. OMAR, Ahmed. M. HAREDY, Sayed. M. DERAYEA
Square-wave Adsorptive Anodic Stripping Voltammetric Determination of Antidiabetic Drug Linagliptin in Pharmaceutical Formulations and Biological Fluids Using a Pencil Graphite Electrode
Analytical Sciences  36(9), 1031, 2020
DOI: 10.2116/analsci.19P469
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[4]. Mohammad Reza Baezzat, Fatemeh Shojaei
Electrochemical sensor based on GCE modified with E-rGO/Poly (B-CD)/magnetic ZIF-67 nanocomposite for the measurement of Linagliptin
Diamond and Related Materials  114, 108345, 2021
DOI: 10.1016/j.diamond.2021.108345
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[5]. H.N. Deepakumari, B. Shyla, H.D. Revanasiddappa
Hypoglycemic Agents: Micro-Determination by Highly Sensitive and Validated Spectrophotometric Techniques
Analytical Chemistry Letters  8(2), 152, 2018
DOI: 10.1080/22297928.2018.1456360
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[6]. Mahmoud A. Omar, Ahmed M. Haredy, Gamal A. Saleh, A.H. Naggar, Sayed M. Derayea
Diarylpyrrolone based fluorophore for the selective spectrofluorometric method for determination of Linagliptin antidiabetic drug in pharmaceutical tablets
Microchemical Journal  148, 555, 2019
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[7]. Heba A. Aref, Sherin F. Hammad, Mohamed Saleh Elgawish, Khaled M. Darwish
Novel spectrofluorimetric quantification of linagliptin in biological fluids exploiting its interaction with 4‐chloro‐7‐nitrobenzofurazan
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[8]. Noha S. Abbas, Sayed M. Derayea, Mahmoud A. Omar, Gamal A. Saleh
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How to cite


El-Bagary, R.; Elkady, E.; Ayoub, B. Eur. J. Chem. 2014, 5(2), 380-382. doi:10.5155/eurjchem.5.2.380-382.845
El-Bagary, R.; Elkady, E.; Ayoub, B. Spectrofluorometric determination of linagliptin in bulk and in pharmaceutical dosage form. Eur. J. Chem. 2014, 5(2), 380-382. doi:10.5155/eurjchem.5.2.380-382.845
El-Bagary, R., Elkady, E., & Ayoub, B. (2014). Spectrofluorometric determination of linagliptin in bulk and in pharmaceutical dosage form. European Journal of Chemistry, 5(2), 380-382. doi:10.5155/eurjchem.5.2.380-382.845
El-Bagary, Ramzia, Ehab Farouk Elkady, & Bassam Mahfouz Ayoub. "Spectrofluorometric determination of linagliptin in bulk and in pharmaceutical dosage form." European Journal of Chemistry [Online], 5.2 (2014): 380-382. Web. 17 Oct. 2021
El-Bagary, Ramzia, Elkady, Ehab, AND Ayoub, Bassam. "Spectrofluorometric determination of linagliptin in bulk and in pharmaceutical dosage form" European Journal of Chemistry [Online], Volume 5 Number 2 (30 June 2014)

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