European Journal of Chemistry

Simple and straight forward synthesis of 2,4-disubstituted quinazolines in aqueous medium



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Madhav Bandaru
Narayana Murthy Sabbavarapu
Anil Kumar Bandam Santosh Pavan
Ashwan Kumar Akula
Nageswar Yadavalli Venkata Durga

Abstract

Efficient synthesis of diverse quinazolines from readily available starting materials was achieved in aqueous medium via one-pot protocol. A number of 2,4-disubstituted quinazolines were prepared in moderate to good yields under mild and catalyst-free conditions. Neutral reaction conditions, easy work-up procedures with wide substrate scope and atom economy are the remarkable features of this method.

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Bandaru, M.; Sabbavarapu, N. M.; Pavan, A. K. B. S.; Akula, A. K.; Durga, N. Y. V. Simple and Straight Forward Synthesis of 2,4-Disubstituted Quinazolines in Aqueous Medium. Eur. J. Chem. 2012, 3, 252-257.

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