Simple and straight forward synthesis of 2,4-disubstituted quinazolines in aqueous medium | European Journal of Chemistry

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Published: Jun 30, 2012

DOI: https://doi.org/10.5155/eurjchem.3.2.252-257.527

Keywords:

Catalyst free, Aqueous medium, One-pot synthesis, Ammonium acetate, 2-Amino carbonyl compounds, 2, 4-Disubstituted quinazolines

Section

Short Communication

Issue

Vol. 3 No. 2 (2012): June 2012

Dates

Received 2011-09-12
Accepted 2011-10-13
Published 2012-06-30

Madhav Bandaru

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Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad, 500607, India

Narayana Murthy Sabbavarapu

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Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad, 500607, India

Anil Kumar Bandam Santosh Pavan

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Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad, 500607, India

Ashwan Kumar Akula

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Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad, 500607, India

Nageswar Yadavalli Venkata Durga

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Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad, 500607, India

Abstract

Efficient synthesis of diverse quinazolines from readily available starting materials was achieved in aqueous medium via one-pot protocol. A number of 2,4-disubstituted quinazolines were prepared in moderate to good yields under mild and catalyst-free conditions. Neutral reaction conditions, easy work-up procedures with wide substrate scope and atom economy are the remarkable features of this method.

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Bandaru, M.; Sabbavarapu, N. M.; Pavan, A. K. B. S.; Akula, A. K.; Durga, N. Y. V. Simple and Straight Forward Synthesis of 2,4-Disubstituted Quinazolines in Aqueous Medium. Eur. J. Chem. 2012, 3, 252-257.

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Supporting Agencies

Council of Scientific and Industrial Research (CSIR), New Delhi, India

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