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Simple and straight forward synthesis of 2,4-disubstituted quinazolines in aqueous medium
Madhav Bandaru (1)
, Narayana Murthy Sabbavarapu (2) , Anil Kumar Bandam Santosh Pavan (3) , Ashwan Kumar Akula (4) , Nageswar Yadavalli Venkata Durga (5,*) (1) Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad, 500607, India
(2) Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad, 500607, India
(3) Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad, 500607, India
(4) Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad, 500607, India
(5) Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad, 500607, India
(*) Corresponding Author
Received: 12 Sep 2011 | Revised: 12 Oct 2011 | Accepted: 13 Oct 2011 | Published: 30 Jun 2012 | Issue Date: June 2012
Abstract
Efficient synthesis of diverse quinazolines from readily available starting materials was achieved in aqueous medium via one-pot protocol. A number of 2,4-disubstituted quinazolines were prepared in moderate to good yields under mild and catalyst-free conditions. Neutral reaction conditions, easy work-up procedures with wide substrate scope and atom economy are the remarkable features of this method.
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DOI: 10.5155/eurjchem.3.2.252-257.527
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Council of Scientific and Industrial Research (CSIR), New Delhi, India
Citations
[1]. M.Carolina A. Carreira, M. Conceição Oliveira, Ana C. Fernandes
One-pot sustainable synthesis of valuable nitrogen compounds from biomass resources
Molecular Catalysis 518, 112094, 2022
DOI: 10.1016/j.mcat.2021.112094
[2]. Subrahmanya Ishwar Bhat, U. K. Das, Darshak R. Trivedi
An Efficient Three-component, One-pot Synthesis of Quinazolines under Solvent-free and Catalyst-free Condition
Journal of Heterocyclic Chemistry 52(4), 1253, 2015
DOI: 10.1002/jhet.2220
[3]. Xinglin Ye, Zhihan Yuan, Yirong Zhou, Qin Yang, Yepeng Xie, Zhihong Deng, Yiyuan Peng
Nickel-catalyzed Kumada Cross-coupling Reaction for the Synthesis of 2,4-Diarylquinazolines
Journal of Heterocyclic Chemistry 53(6), 1956, 2016
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[4]. Wing Cheung, Raymond J. Patch, Mark R. Player
Silver(II) oxide-mediated synthesis of 2,4-diarylquinazolines
Tetrahedron Letters 59(24), 2368, 2018
DOI: 10.1016/j.tetlet.2018.05.019
[5]. Wei Gao, Chun Gong, Qin Yang, Jianjun Yuan, Linchu Xu, Yiyuan Peng
Rh(III)-catalyzed oxidative ortho-C–H alkylation of 2,4-diarylquinazoline with potassium alkyltrifluoroborates
Canadian Journal of Chemistry 95(10), 1052, 2017
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[6]. Tanya Gupta, Ankit Rohilla, Ankita Pathak, Md Jawaid Akhtar, Md Rafi Haider, M. Shahar Yar
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Synthetic Communications 48(10), 1099, 2018
DOI: 10.1080/00397911.2018.1431282
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DOI Link: https://doi.org/10.5155/eurjchem.3.2.252-257.527
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