European Journal of Chemistry

A simple, solvent and catalyst-free green synthetic protocol for α-amino phosphonates

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Ramesh Katla
Narayana Murthy Sabbavarapu
Karnakar Konkala
Nageswar Yadavalli Venkata Durga


A simple and efficient method for the synthesis of α-amino phosphonates has been developed by using aromatic aldehydes, amines, and trimethyl/triethyl phosphite, under catalyst and solvent free conditions, with the formation of the product in good to excellent yields. This method involves milder reaction conditions, easy work-up, and cleaner reaction profiles, and may have wide spread application in organic synthesis.


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How to Cite
Katla, R.; Sabbavarapu, N. M.; Konkala, K.; Durga, N. Y. V. A Simple, Solvent and Catalyst-Free Green Synthetic Protocol for α-Amino Phosphonates. Eur. J. Chem. 2012, 3, 119-124.

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