European Journal of Chemistry 2012, 3(1), 119-124 | doi: https://doi.org/10.5155/eurjchem.3.1.119-124.449 | Get rights and content






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A simple, solvent and catalyst-free green synthetic protocol for α-amino phosphonates


Ramesh Katla (1) , Narayana Murthy Sabbavarapu (2) , Karnakar Konkala (3) , Nageswar Yadavalli Venkata Durga (4,*)

(1) Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500607, India
(2) Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500607, India
(3) Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500607, India
(4) Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500607, India
(*) Corresponding Author

Received: 30 Apr 2011 | Revised: 25 May 2011 | Accepted: 25 May 2011 | Published: 31 Mar 2012 | Issue Date: March 2012

Abstract


A simple and efficient method for the synthesis of α-amino phosphonates has been developed by using aromatic aldehydes, amines, and trimethyl/triethyl phosphite, under catalyst and solvent free conditions, with the formation of the product in good to excellent yields. This method involves milder reaction conditions, easy work-up, and cleaner reaction profiles, and may have wide spread application in organic synthesis.

3_1_119_124_800


Keywords


Amines; Solvent-free; Neat condition; Aromatic aldehydes; Multi component reaction; Trimethyl/triethyl phosphite

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DOI: 10.5155/eurjchem.3.1.119-124.449

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Funding information


Council of Scientific and Industrial Research, New Delhi

Citations

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How to cite


Katla, R.; Sabbavarapu, N.; Konkala, K.; Durga, N. Eur. J. Chem. 2012, 3(1), 119-124. doi:10.5155/eurjchem.3.1.119-124.449
Katla, R.; Sabbavarapu, N.; Konkala, K.; Durga, N. A simple, solvent and catalyst-free green synthetic protocol for α-amino phosphonates. Eur. J. Chem. 2012, 3(1), 119-124. doi:10.5155/eurjchem.3.1.119-124.449
Katla, R., Sabbavarapu, N., Konkala, K., & Durga, N. (2012). A simple, solvent and catalyst-free green synthetic protocol for α-amino phosphonates. European Journal of Chemistry, 3(1), 119-124. doi:10.5155/eurjchem.3.1.119-124.449
Katla, Ramesh, Narayana Murthy Sabbavarapu, Karnakar Konkala, & Nageswar Yadavalli Venkata Durga. "A simple, solvent and catalyst-free green synthetic protocol for α-amino phosphonates." European Journal of Chemistry [Online], 3.1 (2012): 119-124. Web. 24 Jan. 2020
Katla, Ramesh, Sabbavarapu, Narayana, Konkala, Karnakar, AND Durga, Nageswar. "A simple, solvent and catalyst-free green synthetic protocol for α-amino phosphonates" European Journal of Chemistry [Online], Volume 3 Number 1 (31 March 2012)

DOI Link: https://doi.org/10.5155/eurjchem.3.1.119-124.449

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