A simple, solvent and catalyst-free green synthetic protocol for α-amino phosphonates
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Accepted 2011-05-25
Published 2012-03-31
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Abstract
A simple and efficient method for the synthesis of α-amino phosphonates has been developed by using aromatic aldehydes, amines, and trimethyl/triethyl phosphite, under catalyst and solvent free conditions, with the formation of the product in good to excellent yields. This method involves milder reaction conditions, easy work-up, and cleaner reaction profiles, and may have wide spread application in organic synthesis.
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Council of Scientific and Industrial Research, New Delhi
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