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Glycerol mediated, one pot, multicomponent synthesis of dihydropyrano[2,3-c]pyrazoles
Harvinder Singh Sohal (1)
, Arun Goyal (2) , Rajeev Sharma (3) , Rajshree Khare (4) , Sanjay Kumar (5,*) (1) Department of Chemistry, Multani Mal Modi College, Patiala, 147001, Punjab, India
(2) Department of Chemistry, Multani Mal Modi College, Patiala, 147001, Punjab, India
(3) Department of Chemistry, Multani Mal Modi College, Patiala, 147001, Punjab, India
(4) Department of Chemistry, Maharishi Markandeshwar University, Mullana, 133207, Haryana, India
(5) Department of Chemistry, Multani Mal Modi College, Patiala, 147001, Punjab, India
(*) Corresponding Author
Received: 12 Mar 2013 | Revised: 13 Jun 2013 | Accepted: 14 Jun 2013 | Published: 31 Dec 2013 | Issue Date: December 2013
Abstract
Multi component, one pot synthesis of various dihydropyrano[2,3-c]pyrazole derivatives from the condensation of ethyl acetoacetate, hydrazine, aromatic aldehyde and malononitrile has been described using glycerol, as environmentally benign, economical, and easily available solvent. The targeted molecules are obtained in excellent yield without use of any additional catalyst.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.4.4.450-453.769
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Funding information
University Grants Commission (Sanction No. F.No.8-2 (52)/2011 (MRP/NCRB)), New Delhi, India
Citations
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BF3 bonded nano Fe3O4 (BF3/MNPs): an efficient magnetically recyclable catalyst for the synthesis of 1,4-dihydropyrano[2,3-c]pyrazole derivatives
RSC Advances 5(91), 74932, 2015
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[2]. Wenbo Li, Reyhangul Ruzi, Keyume Ablajan, Zulpiya Ghalipt
One-pot synthesis of highly functionalized pyrano[2,3-c]pyrazole-4,4′-diacetate and 6-oxo-pyrano[2,3-c]pyrazole derivatives catalyzed by urea
Tetrahedron 73(2), 164, 2017
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A Green, Novel and Efficient Protocol for the Preparation of Diverse 4H-Pyrans: The First Report on the Catalytic Activity of Water Extract ofElaeagnus angustifoliaLeaves in Organic Reactions
Polycyclic Aromatic Compounds 40(5), 1524, 2020
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[4]. Reza Kordnezhadian, Mohsen Shekouhy, Ali Khalafi-Nezhad
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Molecular Diversity 24(3), 737, 2020
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[5]. Harvinder Singh Sohal, Arun Goyal, Rajshree Khare, Kishanpal Singh, Rajeev Sharma
Catalyst free, one-pot, facile synthesis of novel pyrazolo-1,4-dihydropyridine derivative form pyranopyrazoles
European Journal of Chemistry 5(2), 227, 2014
DOI: 10.5155/eurjchem.5.2.227-232.967
[6]. Junhua Li, Daming Du
Enantioselective Synthesis of N‐Phenyl‐dihydropyrano[2,3‐c]pyrazoles via Cascade Michael Addition/Thorpe‐Ziegler Type Cyclization Catalyzed by a Chiral Squaramide
Chinese Journal of Chemistry 33(4), 418, 2015
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[7]. N Singh, K K Sandhu, H S Sohal, M Kaur
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Materials Today: Proceedings , , 2022
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Current Organocatalysis 10(4), 320, 2023
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DOI Link: https://doi.org/10.5155/eurjchem.4.4.450-453.769
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