Glycerol mediated, one pot, multicomponent synthesis of dihydropyrano[2,3-c]pyrazoles

Harvinder Singh Sohal; Arun Goyal; Rajeev Sharma; Rajshree Khare; Sanjay Kumar

doi:10.5155/eurjchem.4.4.450-453.769

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Published: Dec 31, 2013

DOI: https://doi.org/10.5155/eurjchem.4.4.450-453.769

Keywords:

Glycerol, Aldehydes, Catalyst free, Malononitrile, Pyrazol-5-one, Dihydropyrano[2, 3-c]pyrazole

Section

Research Article

Issue

Vol. 4 No. 4 (2013): December 2013

Dates

Received 2013-03-12
Accepted 2013-06-14
Published 2013-12-31

Harvinder Singh Sohal

Department of Chemistry, Multani Mal Modi College, Patiala, 147001, Punjab, India

Arun Goyal

Department of Chemistry, Multani Mal Modi College, Patiala, 147001, Punjab, India

Rajeev Sharma

Department of Chemistry, Multani Mal Modi College, Patiala, 147001, Punjab, India

Rajshree Khare

Department of Chemistry, Maharishi Markandeshwar University, Mullana, 133207, Haryana, India

Sanjay Kumar

Department of Chemistry, Multani Mal Modi College, Patiala, 147001, Punjab, India

Abstract

Multi component, one pot synthesis of various dihydropyrano[2,3-c]pyrazole derivatives from the condensation of ethyl acetoacetate, hydrazine, aromatic aldehyde and malononitrile has been described using glycerol, as environmentally benign, economical, and easily available solvent. The targeted molecules are obtained in excellent yield without use of any additional catalyst.

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Sohal, H. S.; Goyal, A.; Sharma, R.; Khare, R.; Kumar, S. Glycerol Mediated, One Pot, Multicomponent Synthesis of dihydropyrano[2,3-c]pyrazoles. Eur. J. Chem. 2013, 4, 450-453.

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Supporting Agencies

University Grants Commission (Sanction No. F.No.8-2 (52)/2011 (MRP/NCRB)), New Delhi, India

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