European Journal of Chemistry 2013, 4(4), 450-453. doi:10.5155/eurjchem.4.4.450-453.769

Glycerol mediated, one pot, multicomponent synthesis of dihydropyrano[2,3-c]pyrazoles


Harvinder Singh Sohal (1) , Arun Goyal (2) , Rajeev Sharma (3) , Rajshree Khare (4) , Sanjay Kumar (5,*)

(1) Department of Chemistry, Multani Mal Modi College, Patiala, 147001, Punjab, India
(2) Department of Chemistry, Multani Mal Modi College, Patiala, 147001, Punjab, India
(3) Department of Chemistry, Multani Mal Modi College, Patiala, 147001, Punjab, India
(4) Department of Chemistry, Maharishi Markandeshwar University, Mullana, 133207, Haryana, India
(5) Department of Chemistry, Multani Mal Modi College, Patiala, 147001, Punjab, India
(*) Corresponding Author

Received: 12 Mar 2013, Accepted: 14 Jun 2013, Published: 31 Dec 2013

Abstract


Multi component, one pot synthesis of various dihydropyrano[2,3-c]pyrazole derivatives from the condensation of ethyl acetoacetate, hydrazine, aromatic aldehyde and malononitrile has been described using glycerol, as environmentally benign, economical, and easily available solvent. The targeted molecules are obtained in excellent yield without use of any additional catalyst.

4_4_450_453

Keywords


Glycerol; Aldehydes; Catalyst free; Malononitrile; Pyrazol-5-one; Dihydropyrano[2,3-c]pyrazole

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DOI: 10.5155/eurjchem.4.4.450-453.769

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[2]. Wenbo Li, Reyhangul Ruzi, Keyume Ablajan, Zulpiya Ghalipt
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[4]. Reza Kordnezhadian, Mohsen Shekouhy, Ali Khalafi-Nezhad
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[5]. Harvinder Singh Sohal, Arun Goyal, Rajshree Khare, Kishanpal Singh, Rajeev Sharma
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[6]. Junhua Li, Daming Du
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How to cite


Sohal, H.; Goyal, A.; Sharma, R.; Khare, R.; Kumar, S. Eur. J. Chem. 2013, 4(4), 450-453. doi:10.5155/eurjchem.4.4.450-453.769
Sohal, H.; Goyal, A.; Sharma, R.; Khare, R.; Kumar, S. Glycerol mediated, one pot, multicomponent synthesis of dihydropyrano[2,3-c]pyrazoles. Eur. J. Chem. 2013, 4(4), 450-453. doi:10.5155/eurjchem.4.4.450-453.769
Sohal, H., Goyal, A., Sharma, R., Khare, R., & Kumar, S. (2013). Glycerol mediated, one pot, multicomponent synthesis of dihydropyrano[2,3-c]pyrazoles. European Journal of Chemistry, 4(4), 450-453. doi:10.5155/eurjchem.4.4.450-453.769
Sohal, Harvinder, Arun Goyal, Rajeev Sharma, Rajshree Khare, & Sanjay Kumar. "Glycerol mediated, one pot, multicomponent synthesis of dihydropyrano[2,3-c]pyrazoles." European Journal of Chemistry [Online], 4.4 (2013): 450-453. Web. 18 Sep. 2019
Sohal, Harvinder, Goyal, Arun, Sharma, Rajeev, Khare, Rajshree, AND Kumar, Sanjay. "Glycerol mediated, one pot, multicomponent synthesis of dihydropyrano[2,3-c]pyrazoles" European Journal of Chemistry [Online], Volume 4 Number 4 (31 December 2013)

DOI Link: https://doi.org/10.5155/eurjchem.4.4.450-453.769

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