European Journal of Chemistry

One-pot, multicomponent synthesis of symmetrical Hantzsch 1,4-dihydropyridine derivatives using glycerol as clean and green solvent

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Harvinder Singh Sohal
Arun Goyal
Rajeev Sharma
Rajshree Khare


Multi component, one pot synthesis of symmetrical 1,4-dihydropyridine derivatives from the condensation of ethyl/methyl acetoacetate, aromatic/aliphatic aldehyde and ammonium acetate has been described using glycerol, as economical, easily available and environmentally benign reagent. The targeted molecules were obtained in high purity and excellent yield without use of any additional catalyst and methodology from readily available starting materials.

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Sohal, H. S.; Goyal, A.; Sharma, R.; Khare, R. One-Pot, Multicomponent Synthesis of Symmetrical Hantzsch 1,4-Dihydropyridine Derivatives Using Glycerol As Clean and Green Solvent. Eur. J. Chem. 2014, 5, 171-175.

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[1]. Hantzsch, A. Jusfus Liebigs Ann. Chem. 1882, 215, 1-82.

[2]. Hutton, R. F.; Westheimer, F. H. Tetrahedron 1958, 3, 73-74.

[3]. Rahway, N. J. The Merck Index, 12th edition, Merck Research Laboratories, 1996.

[4]. Bostrom, S. L.; Ljung, B.; Mardh, S.; Forsen, S.; Thulin, E. Nature 1981, 292, 777-778.

[5]. Iwanami, M.; Shibanuma, T.; Fujimoto, M.; Kawai, R.; Tamazawa, K.; Takenaka, T.; Takahashi, K.; Murakami, M. Chem. Pharm. Bull. 1979, 27, 1426-1440.

[6]. Arrowsmith, J. E.; Campbell, S. F.; Cross, P. E.; Stubbs, J. K.; Burges, R. A.; Gardiner, D. G.; Blackburn, K. J. J. Med. Chem. 1986, 29, 1696-1702.

[7]. Goldmann, S.; Stoltefuss, J. Angew. Chem., Int. Ed. Engl. 1991, 30, 1559-1578.

[8]. Boer, R.; Gekeler, V. Drugs Future 1995, 20, 499-509.

[9]. Briukhanov, V. M.; Zverev-laf Elkin, V. I. Exp. Clin. Pharmacol. 1994, 57, 47-49.

[10]. Tusell, J. M.; Serratosa, S. J. Brain Res. 1993, 622, 99-104.

[11]. Wachter, G. A.; Davis, M. C.; Martin, A. R.; Franzblau, S. G. J. Med. Chem. 1998, 41, 2436-2438.

[12]. Desai, B.; Sureja, D.; Naliapara, Y.; Shah, A.; Saxena, A. K. Bioorg. Med. Chem. 2001, 9, 1993-1998.

[13]. Sunkel, C. E.; de Casa-Juana, M. F.; Santos, L.; Gomez, M. M.; Villarroya, M.; Gonzalez-Morales, M. A.; Priego, J. G.; Ortega, M. P. J. Med. Chem. 1990, 33, 3205-3210.

[14]. Rafiee, E.; Eavani, S.; Rashidzadeh, S.; Joshaghani, M. Inorg. Chim. Acta 2009, 362, 3555-3562.

[15]. Kumar, A.; Maurya, R. A. Tetrahedron2008, 64, 3477-3482.

[16]. Davoodnia, A.; Khashi, M.; Niloofar, T. H. Chinese J. Catal. 2013, 34, 1173-1178.

[17]. Ramchander, J.; Raju, G.; Rameshwar, N.; Reddy, T. S.; Reddy A. R. Spectrochimica Acta A 2012, 85, 210-216.

[18]. Kar, P.; Mishra, B. G. Chem. Eng. J. 2013, 223, 647-656.

[19]. Mirzaei, H.; Davoodnia, A. Chin. J. Catal. 2012, 33, 1502-1507.

[20]. Safari, J.; Banitaba, S. H.; Khalil, S. D. Chin. J. Catal. 2011, 32, 1850-1854.

[21]. Lee, Y. A.; Kim, S. C. J. Ind. Eng. Chem. 2011, 17, 401-403.

[22]. Chhillar, A. K.; Arya, P.; Mukherjee, C.; Kumar, P.; Yadav, Y.; Sharma, A. K.; Yadav, V.; Gupta, J.; Dabur, R.; Jha, H. N.; Watterson, A. C.; Parmar, V. S.; Prasadb, A. K.; Sharma, G. L. Bioorg. Med. Chem. 2006, 14, 973-981.

[23]. Kuraitheerthakumaran, A.; Pazhamalai, S.; Gopalakrishnan, M. Chinese Chem. Lett. 2011, 22, 1199-1202.

[24]. Kotharkar, S. A.; Shinde, D. B. Ukrainica Bioorg. Acta 2006, 1, 3-5.

[25]. Wang, S. X.; Li, Z. Y.; Zhang, j. C.; Li, J. T. Ultrason. Sonochem. 2008, 15, 677-680.

[26]. Wolfson, A.; Litvak, G.; Dlugy, C.; Shotland, Y.; Tavor, D. Ind. Crops. Prod. 2009, 30, 78-81.

[27]. Wolfson, A.; Dlugy, C. Chem. Pap. 2007, 61, 228-232.

[28]. Wolfson, A.; Dlugy, C.; Shotland, Y. Environ. Chem. Lett. 2007, 5, 67-71.

[29]. Gu, Y.; Barrault, J.; Jerome, F. Adv. Synth. Catal. 2008, 350, 2007-2012.

[30]. Karam, A.; Villandier, N.; Delample, M.; Koerkamp, C. K.; Douliez, J. P.; Granet, R.; Krausz, P.; Barrault, J.; Jerome, F. Chem. Eur. J. 2008, 14, 10196-10200.

[31]. He, F.; Li, P.; Gu, Y.; Li, G. Green Chem. 2009, 11, 1767-1773.

[32]. Radatz, C. S.; Silva, R. B.; Perin, G.; Lenardao, E. J.; Jacob, R. G.; Alves, D. Tetrahedron Lett. 2011, 52, 4132-4136.

[33]. Nascimento, J. E. R.; Barcellos, A. M.; Sachini, M.; Perin, G.; Lenardao, E. J.; Alves, D.; Jacob, R. G.; Missau, F. Tetrahedron Lett. 2011, 52, 2571-2574.

[34]. Tamaddon, F.; Razmi, Z.; Jafari, A. A. Tetrahedron Lett. 2010, 51, 1187-1189.

[35]. Love, B.; Goodman, M. M.; Snader, K. M.; Tedeschi, R.; Macko, E. Eur. J. Med. Chem. 1974, 17, 956-965.

[36]. Leov, B.; Snader, K. M. J. Org. Chem. 1965, 30, 1914-1916.

[37]. Jacques, J.; Eynde, V.; Delfaese, F.; Mayence, A.; Haverbeke, Y. V. Tetrahedron 1995, 51, 6511-6516.

[38]. Ghosh, S.; Saikh, F.; Das, J.; Pramanik, A. K. Tetrahedron Lett. 2013, 54, 58-62.

[39]. Furniss, B. S.; Hannaford, A. J.; Smith, P. W. G. Text book of Practical Organic Chemistry, 5thed., Longman Singapore, 1994.

[40]. Khadilkar, B. M.; Gaikar, V. G.; Chitnavis, A. A. Tetrahedron lett. 1995, 36, 8083-8086.

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