European Journal of Chemistry 2014, 5(1), 171-175. doi:10.5155/eurjchem.5.1.171-175.943

One-pot, multicomponent synthesis of symmetrical Hantzsch 1,4-dihydropyridine derivatives using glycerol as clean and green solvent


Harvinder Singh Sohal (1,*) , Arun Goyal (2) , Rajeev Sharma (3) , Rajshree Khare (4)

(1) Department of Chemistry, Maharishi Markandeshwar University, Mullana-133 207, Haryana, India
(2) Department of Chemistry, Maharishi Markandeshwar University, Mullana-133 207, Haryana, India
(3) Department of Chemistry, Multani Mal Modi College, Patiala-147 001, Punjab, India
(4) Department of Chemistry, Maharishi Markandeshwar University, Mullana-133 207, Haryana, India
(*) Corresponding Author

Received: 05 Oct 2013, Accepted: 27 Nov 2013, Published: 31 Mar 2014

Abstract


Multi component, one pot synthesis of symmetrical 1,4-dihydropyridine derivatives from the condensation of ethyl/methyl acetoacetate, aromatic/aliphatic aldehyde and ammonium acetate has been described using glycerol, as economical, easily available and environmentally benign reagent. The targeted molecules were obtained in high purity and excellent yield without use of any additional catalyst and methodology from readily available starting materials.


Keywords


One-pot; Glycerol; Aldehydes; Catalyst free; 1,4-Dihydropyridine; Hantzsch condensation

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DOI: 10.5155/eurjchem.5.1.171-175.943

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Citations

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[1]. J. Ashwin Kumar, Gomathi Shridhar, Savita Ladage, Lakshmy Ravishankar
Synthesis of 1,4-dihydropyridine esters using low-melting sugar mixtures as green solvents
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DOI: 10.1080/00397911.2016.1242750
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[2]. Diego da Costa Cabrera, Eduarda Santa-Helena, Heloisa P. Leal, Renata Rodrigues de Moura, Luiz Eduardo Maia Nery, Carla Amorim Neves Gonçalves, Dennis Russowsky, Marcelo G. Montes D'Oca
Synthesis and antioxidant activity of new lipophilic dihydropyridines
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DOI: 10.1016/j.bioorg.2018.11.009
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[3]. Rakesh Kumar, Neha Yadav, Rodolfo Lavilla, Daniel Blasi, Jordi Quintana, José Manuel Brea, María Isabel Loza, Jordi Mestres, Mamta Bhandari, Ritu Arora, Rita Kakkar, Ashok K. Prasad
Synthesis, pharmacological evaluation and molecular docking of pyranopyrazole-linked 1,4-dihydropyridines as potent positive inotropes
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DOI: 10.1007/s11030-017-9738-7
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How to cite


Sohal, H.; Goyal, A.; Sharma, R.; Khare, R. Eur. J. Chem. 2014, 5(1), 171-175. doi:10.5155/eurjchem.5.1.171-175.943
Sohal, H.; Goyal, A.; Sharma, R.; Khare, R. One-pot, multicomponent synthesis of symmetrical Hantzsch 1,4-dihydropyridine derivatives using glycerol as clean and green solvent. Eur. J. Chem. 2014, 5(1), 171-175. doi:10.5155/eurjchem.5.1.171-175.943
Sohal, H., Goyal, A., Sharma, R., & Khare, R. (2014). One-pot, multicomponent synthesis of symmetrical Hantzsch 1,4-dihydropyridine derivatives using glycerol as clean and green solvent. European Journal of Chemistry, 5(1), 171-175. doi:10.5155/eurjchem.5.1.171-175.943
Sohal, Harvinder, Arun Goyal, Rajeev Sharma, & Rajshree Khare. "One-pot, multicomponent synthesis of symmetrical Hantzsch 1,4-dihydropyridine derivatives using glycerol as clean and green solvent." European Journal of Chemistry [Online], 5.1 (2014): 171-175. Web. 17 Sep. 2019
Sohal, Harvinder, Goyal, Arun, Sharma, Rajeev, AND Khare, Rajshree. "One-pot, multicomponent synthesis of symmetrical Hantzsch 1,4-dihydropyridine derivatives using glycerol as clean and green solvent" European Journal of Chemistry [Online], Volume 5 Number 1 (31 March 2014)

DOI Link: https://doi.org/10.5155/eurjchem.5.1.171-175.943

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