One-pot, multicomponent synthesis of symmetrical Hantzsch 1,4-dihydropyridine derivatives using glycerol as clean and green solvent

Harvinder Singh Sohal; Arun Goyal; Rajeev Sharma; Rajshree Khare

doi:10.5155/eurjchem.5.1.171-175.943

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Published: Mar 31, 2014

DOI: https://doi.org/10.5155/eurjchem.5.1.171-175.943

Keywords:

One-pot, Glycerol, Aldehydes, Catalyst free, 1, 4-Dihydropyridine, Hantzsch condensation

Section

Research Article

Issue

Vol. 5 No. 1 (2014): March 2014

Dates

Received 2013-10-05
Accepted 2013-11-27
Published 2014-03-31

Harvinder Singh Sohal

Department of Chemistry, Maharishi Markandeshwar University, Mullana-133 207, Haryana, India

Arun Goyal

Department of Chemistry, Maharishi Markandeshwar University, Mullana-133 207, Haryana, India

Rajeev Sharma

Department of Chemistry, Multani Mal Modi College, Patiala-147 001, Punjab, India

Rajshree Khare

Department of Chemistry, Maharishi Markandeshwar University, Mullana-133 207, Haryana, India

Abstract

Multi component, one pot synthesis of symmetrical 1,4-dihydropyridine derivatives from the condensation of ethyl/methyl acetoacetate, aromatic/aliphatic aldehyde and ammonium acetate has been described using glycerol, as economical, easily available and environmentally benign reagent. The targeted molecules were obtained in high purity and excellent yield without use of any additional catalyst and methodology from readily available starting materials.

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Sohal, H. S.; Goyal, A.; Sharma, R.; Khare, R. One-Pot, Multicomponent Synthesis of Symmetrical Hantzsch 1,4-Dihydropyridine Derivatives Using Glycerol As Clean and Green Solvent. Eur. J. Chem. 2014, 5, 171-175.

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