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One-pot, multicomponent synthesis of symmetrical Hantzsch 1,4-dihydropyridine derivatives using glycerol as clean and green solvent
Harvinder Singh Sohal (1,*)
, Arun Goyal (2) , Rajeev Sharma (3) , Rajshree Khare (4) (1) Department of Chemistry, Maharishi Markandeshwar University, Mullana-133 207, Haryana, India
(2) Department of Chemistry, Maharishi Markandeshwar University, Mullana-133 207, Haryana, India
(3) Department of Chemistry, Multani Mal Modi College, Patiala-147 001, Punjab, India
(4) Department of Chemistry, Maharishi Markandeshwar University, Mullana-133 207, Haryana, India
(*) Corresponding Author
Received: 05 Oct 2013 | Revised: 21 Nov 2013 | Accepted: 27 Nov 2013 | Published: 31 Mar 2014 | Issue Date: March 2014
Abstract
Multi component, one pot synthesis of symmetrical 1,4-dihydropyridine derivatives from the condensation of ethyl/methyl acetoacetate, aromatic/aliphatic aldehyde and ammonium acetate has been described using glycerol, as economical, easily available and environmentally benign reagent. The targeted molecules were obtained in high purity and excellent yield without use of any additional catalyst and methodology from readily available starting materials.
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DOI: 10.5155/eurjchem.5.1.171-175.943
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Maharishi Markandeshwar University, Mullana, Ambala, India
Citations
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Synthesis of 1,4-dihydropyridine esters using low-melting sugar mixtures as green solvents
Synthetic Communications 46(24), 1989, 2016
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Bioorganic Chemistry 84, 1, 2019
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ChemistrySelect 4(38), 11321, 2019
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[4]. Letcy V. Theresa, Shaibuna Machingal, Krishnapillai Sreekumar
Low Melting Mixtures: Neoteric Solvents and/or Catalysts for a Green Approach to Organic Reactions
Mini-Reviews in Organic Chemistry 20(3), 212, 2023
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ACS Omega 7(18), 16055, 2022
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DOI Link: https://doi.org/10.5155/eurjchem.5.1.171-175.943
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