

Synthesis, reactions, antioxidant and anticancer evaluation of some novel coumarin derivatives using ethyl 2-(2-oxo-4-phenyl-2H-chromen-7-yloxy) acetate as a starting material
Ahmed Hamdy Halawa (1)







(1) Chemistry Department, Faculty of Science, Al-Azhar University, 11884, Nasr City, Cairo, Egypt
(2) Chemistry Department, Faculty of Medicine, Jazan Universit y, 82621, Jazan, Saudi Arabia
(3) Chemistry Department, Faculty of Science, Al-Azhar University, 11884, Nasr City, Cairo, Egypt
(4) Chemistry Department, Faculty of Science and Art, Al-Baha University, 1988, Al-Baha, Saudi Arabia
(5) Pharmacology Department, National Research Center, 12622, Dokki, Cairo, Egypt
(6) Chemistry Department, Faculty of Science, Al-Azhar University, 11884, Nasr City, Cairo, Egypt
(7) Chemistry Department, Faculty of Science, Al-Azhar University, 11884, Nasr City, Cairo, Egypt
(*) Corresponding Author
Received: 15 Jun 2013 | Accepted: 15 Sep 2013 | Published: 31 Mar 2014 | Issue Date: March 2014
Abstract
We report on the synthesis of new coumarin derivatives coupled with heterocyclic and bifunctionalized moieties at position 7. The proposed structures were confirmed by correct elemental analysis and spectral data (IR, MS, 1H NMR and 13C NMR). Some selected derivatives were also screened for their antioxidant and anticancer activities. The results indicated that 7-{[6-(4-nitrophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl]methoxy}-4-phenyl-H-chromen-2-one has the highest antioxidant and anticancer activity in tested compounds.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.5.1.111-121.860
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Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
Citations
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DOI: 10.1007/s11164-019-03765-9

[2]. Chuan-Feng Liu, Qing-Kun Shen, Jia-Jun Li, Yu-Shun Tian, Zheshan Quan
Synthesis and biological evaluation of novel 7-hydroxy-4-phenylchromen-2-one–linked to triazole moieties as potent cytotoxic agents
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[3]. Ahmed H. Halawa, Essam M. Eliwa, Ahmed A. Hassan, Hesham S. Nassar, R.A. El-Eisawy, Mohamed Ismail, Marcel Frese, Mohamed Shaaban, Ahmed M. El-Agrody, Ahmed H. Bedair, Norbert Sewald
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[6]. C.G. Arya, Munugala Chandrakanth, K. Fabitha, Neethu Mariam Thomas, Rakendu N. Pramod, Ramesh Gondru, Janardhan Banothu
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