European Journal of Chemistry 2014, 5(4), 595-600 | doi: https://doi.org/10.5155/eurjchem.5.4.595-600.1106 | Get rights and content

Issue cover





  Open Access OPEN ACCESS | Open Access PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS

Synthesis and antioxidant evaluation of some new sulphadimidine incorporating thiophene moiety


Moustafa Ahmed Gouda (1,*) , Hadeer Fakhr Eldien (2) , Margret Mansour Girges (3) , Moged Ahmed Berghot (4)

(1) Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
(2) Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
(3) Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
(4) Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
(*) Corresponding Author

Received: 11 Jun 2014 | Revised: 12 Jul 2014 | Accepted: 12 Jul 2014 | Published: 31 Dec 2014 | Issue Date: December 2014

Abstract


A few new sulphadimidine incorporating thiophene moiety are synthesized. These compounds were assessed by analytical and spectral data. Antioxidant evaluation for the investigated compounds was evaluated by ABTS assay and bleomycin-dependent DNA-damage; the compounds exhibited weak activities.


Announcements


One of our sponsors will cover the article processing fee for all submissions made between May 17, 2023 and June 16, 2023 (Voucher code: SPONSOR2023).

Editor-in-Chief
European Journal of Chemistry

Keywords


Thiophene; Pyrimidine; Sulphadimidine; Cyanoacetamide; Cyanoacetylation; Antioxidant evaluation

Full Text:

PDF
PDF    Open Access

DOI: 10.5155/eurjchem.5.4.595-600.1106

Links for Article


| | | | | | |

| | | | | | |

| | | |

Related Articles




Article Metrics

icon graph This Abstract was viewed 1266 times | icon graph PDF Article downloaded 621 times


Citations

/


[1]. Cansu Gülbenek, Muhammet Yıldırım, Arzu Yıldırım
Microwave-mediated approach to highly substituted nitropyrimidines via double Mannich reactions and their biological properties
Tetrahedron  120, 132904, 2022
DOI: 10.1016/j.tet.2022.132904
/

References


[1]. Okafor, E. C.; Adiukwu, P. U. ; Uzoukwu, B. A. Synth. React. Inorg. Met. Org. Chem. 1993, 23, 97-111.
http://dx.doi.org/10.1080/15533179308016620

[2]. Tantawy, A.; Goda, F.; Abdelal, A. M. Chin. Pharm. J. 1995, 47, 37-45.

[3]. Ojha, A. C.; Jain, R. Pol. J. Chem. 1982, 56, 1553-1560.

[4]. Ferguson, G. N.; Valant, C.; Horne, J.; Figler, H.; Flynn, B. L.; Linden, J.; Chalmers, D. K.; Sexton, P. M.; Christopoulos A.; Scammells, P. J. J. Med. Chem. 2008, 51(19), 6165-6172.
http://dx.doi.org/10.1021/jm800557d

[5]. Nikolakopoulos, G.; Figler, H.; Linden, J.; Scammells, P. J. Bioorg. Med. Chem. 2006, 14, 2358-2365.
http://dx.doi.org/10.1016/j.bmc.2005.11.018

[6]. Gutschow, M.; Kuerschner, L.; Neumann, U.; Pietsch, M.; Loser, R.; Koglin N.; Eger, K. J. Med. Chem. 1999, 42(26), 5437-5447.
http://dx.doi.org/10.1021/jm991108w

[7]. Gutschow, M.; Neumann, U. J. Med. Chem. 1998, 41(10), 1729-1740.
http://dx.doi.org/10.1021/jm9708341

[8]. Koebel, R. F.; Needham L. L.; Witt Blanton, C. J. Med. Chem. 1975, 18, 192-194.
http://dx.doi.org/10.1021/jm00236a018

[9]. Huybrechts, L.; Buffel, D.; Freyne, E.; Hoornaert, G. Tetrahedron 1984, 40(13), 2479-2485.
http://dx.doi.org/10.1016/S0040-4020(01)83500-6

[10]. Mubarak, A. T.; El-Sonbati, A. Z.; El-Bindary, A. A. Chem. Pap. 2004, 58, 320-323.

[11]. El-Bindary, A. A.; El-Sonbati, A. Z. Polish J. Chem. 2000, 74, 615-620.

[12]. Al-Sarawy, A. A.; El-Bindary, A. A.; El-Sonbati, A. Z.; Makpel, M. M. Polish J. Chem. 2006, 80, 289-295.

[13]. El-Sonbati, A. Z.; El-Bindary, A. A.; Ahmed, R. M. Spectrochim. Acta A 2002, 58, 333-339.
http://dx.doi.org/10.1016/S1386-1425(01)00538-8

[14]. El-Sonbati, A. Z.; El-Bindary, A. A.; Mabrouk, E. M.; Ahmed, R. M. Spectrochim. Acta A 2001, 57, 1751-1757
http://dx.doi.org/10.1016/S1386-1425(01)00420-6

[15]. El-Sonbati, A. Z.; Diab, M. A.; El-Shehawy, M. S.; Moqbal, M. P. Spectrochim. Acta A 2010, 75, 394-405.
http://dx.doi.org/10.1016/j.saa.2009.10.047

[16]. Gouda, M. A.; Abu-Hashem, A. A. Arch. Pharm. (Weinheim) 2011, 344(3), 170-177.
http://dx.doi.org/10.1002/ardp.201000165

[17]. El Bialya, S. A. A.; Gouda, M. A. J. Heterocyclic Chem. 2011, 48(6), 1280-1286.
http://dx.doi.org/10.1002/jhet.634

[18]. Hamama, W. S.; Berghot, M. A.; Baz, E. A.; Gouda, M. A. Arch. Pharm. (Weinheim) 2011, 344 (11), 710-718.
http://dx.doi.org/10.1002/ardp.201000263

[19]. Hamama, W. S.; Zoorob, H. H.; Gouda, M. A.; Afsah, E. M. Pharm. Chem. J. 2011, 45(2), 118-124.
http://dx.doi.org/10.1007/s11094-011-0573-3

[20]. Gouda, M. A.; Berghot, M. A.; Baz, E. A.; Hamama, W. S. Med. Chem. Res. 2012, 21, 1062-1070.
http://dx.doi.org/10.1007/s00044-011-9610-8

[21]. Lissi, E. A.; Modak, B.; Torres, R.; Esocbar, J.; Urzua A. Free Radical Res. 1999, 30(6), 471-477.
http://dx.doi.org/10.1080/10715769900300511

[22]. Aeschbach, R.; Loliger, J.; Scott, B. C.; Murcia, A.; Butler, J.; Halliwell, B.; Aruoma, O. I. Food Chem. Toxicol. 1994, 32(1), 31-36.
http://dx.doi.org/10.1016/0278-6915(84)90033-4

[23]. Chan, T. Y.; Tang P. L. J. Pineal Res. 1996, 20, 187-191.
http://dx.doi.org/10.1111/j.1600-079X.1996.tb00257.x

[24]. Tumer, F.; Ekinci, D.; Zilbeyaz, K.; Demir, U. Turk. J. Chem. 2004, 28, 395-404.

[25]. Gewald K. Chem. Ber. 1965, 98(11), 3571-3577.
http://dx.doi.org/10.1002/cber.19650981120

[26]. Ried, W.; Schleimer, B. Angew. Chem. 1958, 70, 164-69.

[27]. Gorobets, N. Y.; Yousef, B. H.; Belaj, F.; Kappe. C. O. Tetrahedron 2004, 60(39), 8633-8644.
http://dx.doi.org/10.1016/j.tet.2004.05.100

[28]. Soliman, A. M.; Khodairy, A.; Ahmed E. A. Phosphorus Sulfur 2003, 178 (4), 649-665.
http://dx.doi.org/10.1080/10426500307793

[29]. Gutteridge, J. M. C.; Rowley, D. A.; Halliwell B. Biochem. J. 1981, 199, 263-265.


How to cite


Gouda, M.; Eldien, H.; Girges, M.; Berghot, M. Eur. J. Chem. 2014, 5(4), 595-600. doi:10.5155/eurjchem.5.4.595-600.1106
Gouda, M.; Eldien, H.; Girges, M.; Berghot, M. Synthesis and antioxidant evaluation of some new sulphadimidine incorporating thiophene moiety. Eur. J. Chem. 2014, 5(4), 595-600. doi:10.5155/eurjchem.5.4.595-600.1106
Gouda, M., Eldien, H., Girges, M., & Berghot, M. (2014). Synthesis and antioxidant evaluation of some new sulphadimidine incorporating thiophene moiety. European Journal of Chemistry, 5(4), 595-600. doi:10.5155/eurjchem.5.4.595-600.1106
Gouda, Moustafa, Hadeer Fakhr Eldien, Margret Mansour Girges, & Moged Ahmed Berghot. "Synthesis and antioxidant evaluation of some new sulphadimidine incorporating thiophene moiety." European Journal of Chemistry [Online], 5.4 (2014): 595-600. Web. 4 Jun. 2023
Gouda, Moustafa, Eldien, Hadeer, Girges, Margret, AND Berghot, Moged. "Synthesis and antioxidant evaluation of some new sulphadimidine incorporating thiophene moiety" European Journal of Chemistry [Online], Volume 5 Number 4 (31 December 2014)

The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item



DOI Link: https://doi.org/10.5155/eurjchem.5.4.595-600.1106


CrossRef | Scilit | GrowKudos | Researchgate | Publons | ScienceGate | Scite | Lens | OUCI

WorldCat Paperbuzz | LibKey Citeas | Dimensions | Semanticscholar | Plumx | Kopernio | Zotero | Mendeley

ZoteroSave to Zotero MendeleySave to Mendeley



European Journal of Chemistry 2014, 5(4), 595-600 | doi: https://doi.org/10.5155/eurjchem.5.4.595-600.1106 | Get rights and content

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c)




© Copyright 2010 - 2023 • Atlanta Publishing House LLC • All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2010-2023 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.