European Journal of Chemistry

Synthesis and antioxidant evaluation of some new sulphadimidine incorporating thiophene moiety

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Published: Dec 31, 2014
DOI: https://doi.org/10.5155/eurjchem.5.4.595-600.1106
Keywords:
Thiophene, Pyrimidine, Sulphadimidine, Cyanoacetamide, Cyanoacetylation, Antioxidant evaluation
Section
Research Article
Issue
Vol. 5 No. 4 (2014): December 2014
Dates
Received 2014-06-11
Accepted 2014-07-12
Published 2014-12-31


Main Article Content

Moustafa Ahmed Gouda
Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
Hadeer Fakhr Eldien
Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
Margret Mansour Girges
Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
Moged Ahmed Berghot
Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt

Abstract

A few new sulphadimidine incorporating thiophene moiety are synthesized. These compounds were assessed by analytical and spectral data. Antioxidant evaluation for the investigated compounds was evaluated by ABTS assay and bleomycin-dependent DNA-damage; the compounds exhibited weak activities.


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Gouda, M. A.; Eldien, H. F.; Girges, M. M.; Berghot, M. A. Synthesis and Antioxidant Evaluation of Some New Sulphadimidine Incorporating Thiophene Moiety. Eur. J. Chem. 2014, 5, 595-600.

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