European Journal of Chemistry

Synthesis and antioxidant evaluation of some new sulphadimidine incorporating thiophene moiety

Article Sidebar

PDF
Published: Dec 31, 2014
DOI: https://doi.org/10.5155/eurjchem.5.4.595-600.1106
Keywords:
Thiophene, Pyrimidine, Sulphadimidine, Cyanoacetamide, Cyanoacetylation, Antioxidant evaluation
Section
Research Article
Issue
Vol. 5 No. 4 (2014): December 2014
Dates
Received 2014-06-11
Accepted 2014-07-12
Published 2014-12-31


Main Article Content

Moustafa Ahmed Gouda
Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
Hadeer Fakhr Eldien
Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
Margret Mansour Girges
Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
Moged Ahmed Berghot
Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt

Abstract

A few new sulphadimidine incorporating thiophene moiety are synthesized. These compounds were assessed by analytical and spectral data. Antioxidant evaluation for the investigated compounds was evaluated by ABTS assay and bleomycin-dependent DNA-damage; the compounds exhibited weak activities.


icon graph This Abstract was viewed 1708 times | icon graph Article PDF downloaded 968 times

How to Cite
(1)
Gouda, M. A.; Eldien, H. F.; Girges, M. M.; Berghot, M. A. Synthesis and Antioxidant Evaluation of Some New Sulphadimidine Incorporating Thiophene Moiety. Eur. J. Chem. 2014, 5, 595-600.

Article Details

Share
Links for Article


Crossref - Scopus - Google - European PMC
Crossref
Scopus
Google Scholar
Europe PMC
References

[1]. Okafor, E. C.; Adiukwu, P. U. ; Uzoukwu, B. A. Synth. React. Inorg. Met. Org. Chem. 1993, 23, 97-111.
http://dx.doi.org/10.1080/15533179308016620

[2]. Tantawy, A.; Goda, F.; Abdelal, A. M. Chin. Pharm. J. 1995, 47, 37-45.

[3]. Ojha, A. C.; Jain, R. Pol. J. Chem. 1982, 56, 1553-1560.

[4]. Ferguson, G. N.; Valant, C.; Horne, J.; Figler, H.; Flynn, B. L.; Linden, J.; Chalmers, D. K.; Sexton, P. M.; Christopoulos A.; Scammells, P. J. J. Med. Chem. 2008, 51(19), 6165-6172.
http://dx.doi.org/10.1021/jm800557d

[5]. Nikolakopoulos, G.; Figler, H.; Linden, J.; Scammells, P. J. Bioorg. Med. Chem. 2006, 14, 2358-2365.
http://dx.doi.org/10.1016/j.bmc.2005.11.018

[6]. Gutschow, M.; Kuerschner, L.; Neumann, U.; Pietsch, M.; Loser, R.; Koglin N.; Eger, K. J. Med. Chem. 1999, 42(26), 5437-5447.
http://dx.doi.org/10.1021/jm991108w

[7]. Gutschow, M.; Neumann, U. J. Med. Chem. 1998, 41(10), 1729-1740.
http://dx.doi.org/10.1021/jm9708341

[8]. Koebel, R. F.; Needham L. L.; Witt Blanton, C. J. Med. Chem. 1975, 18, 192-194.
http://dx.doi.org/10.1021/jm00236a018

[9]. Huybrechts, L.; Buffel, D.; Freyne, E.; Hoornaert, G. Tetrahedron 1984, 40(13), 2479-2485.
http://dx.doi.org/10.1016/S0040-4020(01)83500-6

[10]. Mubarak, A. T.; El-Sonbati, A. Z.; El-Bindary, A. A. Chem. Pap. 2004, 58, 320-323.

[11]. El-Bindary, A. A.; El-Sonbati, A. Z. Polish J. Chem. 2000, 74, 615-620.

[12]. Al-Sarawy, A. A.; El-Bindary, A. A.; El-Sonbati, A. Z.; Makpel, M. M. Polish J. Chem. 2006, 80, 289-295.

[13]. El-Sonbati, A. Z.; El-Bindary, A. A.; Ahmed, R. M. Spectrochim. Acta A 2002, 58, 333-339.
http://dx.doi.org/10.1016/S1386-1425(01)00538-8

[14]. El-Sonbati, A. Z.; El-Bindary, A. A.; Mabrouk, E. M.; Ahmed, R. M. Spectrochim. Acta A 2001, 57, 1751-1757
http://dx.doi.org/10.1016/S1386-1425(01)00420-6

[15]. El-Sonbati, A. Z.; Diab, M. A.; El-Shehawy, M. S.; Moqbal, M. P. Spectrochim. Acta A 2010, 75, 394-405.
http://dx.doi.org/10.1016/j.saa.2009.10.047

[16]. Gouda, M. A.; Abu-Hashem, A. A. Arch. Pharm. (Weinheim) 2011, 344(3), 170-177.
http://dx.doi.org/10.1002/ardp.201000165

[17]. El Bialya, S. A. A.; Gouda, M. A. J. Heterocyclic Chem. 2011, 48(6), 1280-1286.
http://dx.doi.org/10.1002/jhet.634

[18]. Hamama, W. S.; Berghot, M. A.; Baz, E. A.; Gouda, M. A. Arch. Pharm. (Weinheim) 2011, 344 (11), 710-718.
http://dx.doi.org/10.1002/ardp.201000263

[19]. Hamama, W. S.; Zoorob, H. H.; Gouda, M. A.; Afsah, E. M. Pharm. Chem. J. 2011, 45(2), 118-124.
http://dx.doi.org/10.1007/s11094-011-0573-3

[20]. Gouda, M. A.; Berghot, M. A.; Baz, E. A.; Hamama, W. S. Med. Chem. Res. 2012, 21, 1062-1070.
http://dx.doi.org/10.1007/s00044-011-9610-8

[21]. Lissi, E. A.; Modak, B.; Torres, R.; Esocbar, J.; Urzua A. Free Radical Res. 1999, 30(6), 471-477.
http://dx.doi.org/10.1080/10715769900300511

[22]. Aeschbach, R.; Loliger, J.; Scott, B. C.; Murcia, A.; Butler, J.; Halliwell, B.; Aruoma, O. I. Food Chem. Toxicol. 1994, 32(1), 31-36.
http://dx.doi.org/10.1016/0278-6915(84)90033-4

[23]. Chan, T. Y.; Tang P. L. J. Pineal Res. 1996, 20, 187-191.
http://dx.doi.org/10.1111/j.1600-079X.1996.tb00257.x

[24]. Tumer, F.; Ekinci, D.; Zilbeyaz, K.; Demir, U. Turk. J. Chem. 2004, 28, 395-404.

[25]. Gewald K. Chem. Ber. 1965, 98(11), 3571-3577.
http://dx.doi.org/10.1002/cber.19650981120

[26]. Ried, W.; Schleimer, B. Angew. Chem. 1958, 70, 164-69.

[27]. Gorobets, N. Y.; Yousef, B. H.; Belaj, F.; Kappe. C. O. Tetrahedron 2004, 60(39), 8633-8644.
http://dx.doi.org/10.1016/j.tet.2004.05.100

[28]. Soliman, A. M.; Khodairy, A.; Ahmed E. A. Phosphorus Sulfur 2003, 178 (4), 649-665.
http://dx.doi.org/10.1080/10426500307793

[29]. Gutteridge, J. M. C.; Rowley, D. A.; Halliwell B. Biochem. J. 1981, 199, 263-265.

Supporting Agencies

Most read articles by the same author(s)
TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2025 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).