European Journal of Chemistry

One-pot pseudo five-component synthesis and antioxidant evaluation of 4,4'-(aryl-methylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)

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Published: Sep 30, 2016
DOI: https://doi.org/10.5155/eurjchem.7.3.363-367.1474
Keywords:
Arylmethylene, Bis-pyrazol-5-ol, Michael reaction, One pot reaction, Antioxidant activity, Tandem Knoevenagel reaction
Section
Research Article
Issue
Vol. 7 No. 3 (2016): September 2016
Dates
Received 2016-07-09
Accepted 2016-07-23
Published 2016-09-30


Main Article Content

Moustafa Ahmed Gouda
Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
Majed Musallam Mutlaq Al‐Balawi
Department of Chemistry, Faculty of Science and Arts, Taibah University, Ulla, 41411, Kingdom of Saudi Arabia
Ameen Ali Abu-Hashem
Department of Photochemistry, National Research Center, Dokki, Giza 12622, Egypt

Abstract

A simple method for the synthesis of some 4,4'-(aryl-methylene)bis(3-methyl-1H-pyrazol-5-ol) derivatives via a one-pot pseudo five-component reaction of phenyl hydrazine, ethyl acetoacetate and aldehydes in acetic acid is reported. The prepared compounds were characterized by elemental analyses and spectral data. Some of the synthesized compounds were screened for their antioxidant activity using 2,2'-azino-bis(3-ethyl benzothiazoline-6-sulfonic acid (ABTS) method; all the investigated compounds showed similar and higher antioxidant activity than ascorbic acid and exhibited high protection against DNA damage induced by the bleomycin iron complex.


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Gouda, M. A.; Al‐Balawi, M. M. M.; Abu-Hashem, A. A. One-Pot Pseudo Five-Component Synthesis and Antioxidant Evaluation of 4,4’-(aryl-methylene)bis(3-Methyl-1-Phenyl-1H-Pyrazol-5-Ol). Eur. J. Chem. 2016, 7, 363-367.

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