European Journal of Chemistry 2015, 6(1), 84-87 | doi: | Get rights and content

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Synthesis and antioxidant evaluation of some new pyridines

Moustafa Ahmed Gouda (1,*) , Mohamed Hamdy Helal (2)

(1) Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
(2) Department of Chemistry, Faculty of Arts and Science, Northern Border University, Rafha, 1321, Kingdom of Saudi Arabia
(*) Corresponding Author

Received: 09 Sep 2014 | Revised: 16 Feb 2015 | Accepted: 09 Oct 2014 | Published: 31 Mar 2015 | Issue Date: March 2015


One-pot condensation of malononitrile (1), 4-methylpentan-2-one (2), aryl carboxaldehyde (3a-f) and ammonium acetate in ethanol afforded 2-amino-5-isopropyl-4-(4-aryl)-6-methylnicotinonitriles (4a-f). The antioxidant activity of the new synthesized compounds was evaluated and the result showed all compound exhibited weak anti-oxidant activities.


Pyridine; Malononitrile; Nicotinonitrile; Antioxidant activity; Aryl carboxaldehyde; 4-Methylpentan-2-one

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DOI: 10.5155/eurjchem.6.1.84-87.1149

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[1]. Hulme, C.; Gore, V. Curr. Med. Chem. 2003, 10, 51-80.

[2]. Zhu, J. Eur. J. Org. Chem. 2003, 2003(7), 1133-1144.

[3]. Zhu, J.; Bienayme, H. Multicomponent Reactions, 1st edition, Wiley Weinheim, Germany, 2005.

[4]. Lu, K.; Luo, T.; Xiang, Z.; You, Z.; Fathi, R.; Chen, J.; Yang, Z. A. J. Comb. Chem. 2005, 7, 958-967.

[5]. Choi, W. B.; Houpis, I. N.; Churchil, H. R. O.; Molina, A. Lynch, J. J. E.; Volante, R.; P.; Reider, P. J.; King, A. O. A. Tetrahedron Lett. 1995, 36, 4571-4574.

[6]. Song, Z. S.; Zhao, M.; Desmond, R.; Devine, P.; Tschaen, D. M.; Tillyer, R.; Frey, L.; Heid, R.; Xu, F; Foster, B.; Li, J.; Reamer, R.; Volante R, Grabowski, E. J.; Dolling, U. H.; Reider, P. J. J. Org. Chem. 1999, 64, 9658-9667.

[7]. Li, A. H.; Moro, S.; Forsyth, N.; Melman, N.; Ji, X. D.; Jacobsen, K. A. J. Med. Chem. 1999, 42, 706-721.

[8]. Zhang, Y.; Pavlova, O. A.; Chefer, S. I.; Hall, A. W.; Kurian, V.; Brown, L. L.; Kimes, A. S.; Mukhin, A. G.; Horti, A. G. J. Med. Chem. 2004, 47, 2453-2465.

[9]. Chang, C. S.; Lin, Y. T.; Shih, S. R.; Lee, C. C.; Lee, Y. C.; Tai, C. L.; Tseng, S. N.; Chern, J. H. J. Med. Chem. 2005, 48, 3522-3535.

[10]. Baldwin, J. J.; Engelhardt, E. L.; Hirschmann, R.; Ponticello, G. S.; Atkinson, J. G.; Wasson, B. K.; Sweet, C. S.; Scriabine, A. J. Med. Chem. 1980, 23, 65-70.

[11]. Hartmann, R. E.; Shah, A.; Fagan, A. M.; Schwetye, K. E.; Parsadanian, M.; Schulman, R. N.; Finn, M. B.; Holtzman, D. M.; Neurobiol Dis. 2006, 24, 506-515.

[12]. Manna, F.; Chimenti. F.; Bolasco, A.; Filippelli, A.; Palla, A.; Filippelli, W.; Lampa, E.; Mercantini, R. Eur. J. Med. Chem. 1992, 27, 627-632.

[13]. Manna, F.; Chimenti, F.; Bolasco, A.; Bizzarri, B.; Filippelli, W.; Filippelli, A.; Gagliardi, L. Eur. J. Med. Chem. 1999, 34, 245-254.

[14]. Murata, T.; Shimada, M.; Sakakibara, S.; Yoshino, T.; Masuda, T. Shintani, T.; Sato, H.; Koriyama, Y.; Fukushima, K.; Nunami, N.; Yamauchi, M.; Fuchikami, K.; Komura, H.; Watanabe, A.; Ziegelbauer, K. B.; Bacon, K. B.; Lowinger, T. B. Bioorg. Med. Chem. Lett. 2004, 14, 4019-4022.

[15]. Costa, D.; Gomes, A.; Lima, J. L. F. C.; Fernandes, E. Redox. Rep. 2008, 13, 153-160.

[16]. Costa, D.; Vieira, A.; Fernandes, E.; Redox. Rep. 2006, 11, 136-142.

[17]. Gholap, A. R.; Toti, K. S.; Shirazi, F.; Kumari, R.; Bhat, M. K.; Deshpande, M. V.; Srinivasan, K. V. Bioorg. Med. Chem. 2007, 15(21), 6705-6715.

[18]. Lissi, E.; Modak, B.; Torres, R.; Escobar, J. Urza, A. Free Radical Res. 1999, 30, 471- 477.

[19]. Gouda, M. A. Archiv der Pharm. 2012, 345(2), 155-162.

[20]. Metwally, M. A.; Gouda, M. A.; Ammar, N. H.; Khalil, A. M. Eur. J. Med. Chem. 2012, 56, 254-262.

How to cite

Gouda, M.; Helal, M. Eur. J. Chem. 2015, 6(1), 84-87. doi:10.5155/eurjchem.6.1.84-87.1149
Gouda, M.; Helal, M. Synthesis and antioxidant evaluation of some new pyridines. Eur. J. Chem. 2015, 6(1), 84-87. doi:10.5155/eurjchem.6.1.84-87.1149
Gouda, M., & Helal, M. (2015). Synthesis and antioxidant evaluation of some new pyridines. European Journal of Chemistry, 6(1), 84-87. doi:10.5155/eurjchem.6.1.84-87.1149
Gouda, Moustafa, & Mohamed Hamdy Helal. "Synthesis and antioxidant evaluation of some new pyridines." European Journal of Chemistry [Online], 6.1 (2015): 84-87. Web. 25 Sep. 2021
Gouda, Moustafa, AND Helal, Mohamed. "Synthesis and antioxidant evaluation of some new pyridines" European Journal of Chemistry [Online], Volume 6 Number 1 (31 March 2015)

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