European Journal of Chemistry

Synthesis and antioxidant evaluation of some new pyridines

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Moustafa Ahmed Gouda
Mohamed Hamdy Helal


One-pot condensation of malononitrile (1), 4-methylpentan-2-one (2), aryl carboxaldehyde (3a-f) and ammonium acetate in ethanol afforded 2-amino-5-isopropyl-4-(4-aryl)-6-methylnicotinonitriles (4a-f). The antioxidant activity of the new synthesized compounds was evaluated and the result showed all compound exhibited weak anti-oxidant activities.

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Gouda, M. A.; Helal, M. H. Synthesis and Antioxidant Evaluation of Some New Pyridines. Eur. J. Chem. 2015, 6, 84-87.

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