European Journal of Chemistry

Synthesis and antioxidant evaluation of some new pyridines



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Moustafa Ahmed Gouda
Mohamed Hamdy Helal

Abstract

One-pot condensation of malononitrile (1), 4-methylpentan-2-one (2), aryl carboxaldehyde (3a-f) and ammonium acetate in ethanol afforded 2-amino-5-isopropyl-4-(4-aryl)-6-methylnicotinonitriles (4a-f). The antioxidant activity of the new synthesized compounds was evaluated and the result showed all compound exhibited weak anti-oxidant activities.


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Gouda, M. A.; Helal, M. H. Synthesis and Antioxidant Evaluation of Some New Pyridines. Eur. J. Chem. 2015, 6, 84-87.

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References

[1]. Hulme, C.; Gore, V. Curr. Med. Chem. 2003, 10, 51-80.
http://dx.doi.org/10.2174/0929867033368600

[2]. Zhu, J. Eur. J. Org. Chem. 2003, 2003(7), 1133-1144.
http://dx.doi.org/10.1002/ejoc.200390167

[3]. Zhu, J.; Bienayme, H. Multicomponent Reactions, 1st edition, Wiley Weinheim, Germany, 2005.
http://dx.doi.org/10.1002/3527605118

[4]. Lu, K.; Luo, T.; Xiang, Z.; You, Z.; Fathi, R.; Chen, J.; Yang, Z. A. J. Comb. Chem. 2005, 7, 958-967.
http://dx.doi.org/10.1021/cc050099b

[5]. Choi, W. B.; Houpis, I. N.; Churchil, H. R. O.; Molina, A. Lynch, J. J. E.; Volante, R.; P.; Reider, P. J.; King, A. O. A. Tetrahedron Lett. 1995, 36, 4571-4574.
http://dx.doi.org/10.1016/0040-4039(95)00850-C

[6]. Song, Z. S.; Zhao, M.; Desmond, R.; Devine, P.; Tschaen, D. M.; Tillyer, R.; Frey, L.; Heid, R.; Xu, F; Foster, B.; Li, J.; Reamer, R.; Volante R, Grabowski, E. J.; Dolling, U. H.; Reider, P. J. J. Org. Chem. 1999, 64, 9658-9667.
http://dx.doi.org/10.1021/jo991292t

[7]. Li, A. H.; Moro, S.; Forsyth, N.; Melman, N.; Ji, X. D.; Jacobsen, K. A. J. Med. Chem. 1999, 42, 706-721.
http://dx.doi.org/10.1021/jm980550w

[8]. Zhang, Y.; Pavlova, O. A.; Chefer, S. I.; Hall, A. W.; Kurian, V.; Brown, L. L.; Kimes, A. S.; Mukhin, A. G.; Horti, A. G. J. Med. Chem. 2004, 47, 2453-2465.
http://dx.doi.org/10.1021/jm030432v

[9]. Chang, C. S.; Lin, Y. T.; Shih, S. R.; Lee, C. C.; Lee, Y. C.; Tai, C. L.; Tseng, S. N.; Chern, J. H. J. Med. Chem. 2005, 48, 3522-3535.
http://dx.doi.org/10.1021/jm050033v

[10]. Baldwin, J. J.; Engelhardt, E. L.; Hirschmann, R.; Ponticello, G. S.; Atkinson, J. G.; Wasson, B. K.; Sweet, C. S.; Scriabine, A. J. Med. Chem. 1980, 23, 65-70.
http://dx.doi.org/10.1021/jm00175a012

[11]. Hartmann, R. E.; Shah, A.; Fagan, A. M.; Schwetye, K. E.; Parsadanian, M.; Schulman, R. N.; Finn, M. B.; Holtzman, D. M.; Neurobiol Dis. 2006, 24, 506-515.
http://dx.doi.org/10.1016/j.nbd.2006.08.006

[12]. Manna, F.; Chimenti. F.; Bolasco, A.; Filippelli, A.; Palla, A.; Filippelli, W.; Lampa, E.; Mercantini, R. Eur. J. Med. Chem. 1992, 27, 627-632.
http://dx.doi.org/10.1016/0223-5234(92)90141-M

[13]. Manna, F.; Chimenti, F.; Bolasco, A.; Bizzarri, B.; Filippelli, W.; Filippelli, A.; Gagliardi, L. Eur. J. Med. Chem. 1999, 34, 245-254.
http://dx.doi.org/10.1016/S0223-5234(99)80057-9

[14]. Murata, T.; Shimada, M.; Sakakibara, S.; Yoshino, T.; Masuda, T. Shintani, T.; Sato, H.; Koriyama, Y.; Fukushima, K.; Nunami, N.; Yamauchi, M.; Fuchikami, K.; Komura, H.; Watanabe, A.; Ziegelbauer, K. B.; Bacon, K. B.; Lowinger, T. B. Bioorg. Med. Chem. Lett. 2004, 14, 4019-4022.
http://dx.doi.org/10.1016/j.bmcl.2004.05.041

[15]. Costa, D.; Gomes, A.; Lima, J. L. F. C.; Fernandes, E. Redox. Rep. 2008, 13, 153-160.
http://dx.doi.org/10.1179/135100008X308876

[16]. Costa, D.; Vieira, A.; Fernandes, E.; Redox. Rep. 2006, 11, 136-142.
http://dx.doi.org/10.1179/135100006X116637

[17]. Gholap, A. R.; Toti, K. S.; Shirazi, F.; Kumari, R.; Bhat, M. K.; Deshpande, M. V.; Srinivasan, K. V. Bioorg. Med. Chem. 2007, 15(21), 6705-6715.
http://dx.doi.org/10.1016/j.bmc.2007.08.009

[18]. Lissi, E.; Modak, B.; Torres, R.; Escobar, J. Urza, A. Free Radical Res. 1999, 30, 471- 477.
http://dx.doi.org/10.1080/10715769900300511

[19]. Gouda, M. A. Archiv der Pharm. 2012, 345(2), 155-162.
http://dx.doi.org/10.1002/ardp.201100171

[20]. Metwally, M. A.; Gouda, M. A.; Ammar, N. H.; Khalil, A. M. Eur. J. Med. Chem. 2012, 56, 254-262.
http://dx.doi.org/10.1016/j.ejmech.2012.08.034

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