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Synthesis and antioxidant evaluation of some new pyridines
Moustafa Ahmed Gouda (1,*)
, Mohamed Hamdy Helal (2) (1) Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
(2) Department of Chemistry, Faculty of Arts and Science, Northern Border University, Rafha, 1321, Kingdom of Saudi Arabia
(*) Corresponding Author
Received: 09 Sep 2014 | Revised: 16 Feb 2015 | Accepted: 09 Oct 2014 | Published: 31 Mar 2015 | Issue Date: March 2015
Abstract
One-pot condensation of malononitrile (1), 4-methylpentan-2-one (2), aryl carboxaldehyde (3a-f) and ammonium acetate in ethanol afforded 2-amino-5-isopropyl-4-(4-aryl)-6-methylnicotinonitriles (4a-f). The antioxidant activity of the new synthesized compounds was evaluated and the result showed all compound exhibited weak anti-oxidant activities.
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DOI: 10.5155/eurjchem.6.1.84-87.1149
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Citations
[1]. Reda Mohammed Keshk
Design and synthesis of new series of 3‐cyanopyridine and pyrazolopyridine derivatives
Journal of Heterocyclic Chemistry , , 2020
DOI: 10.1002/jhet.4058
[2]. M. A. Salem, M. H. Helel, M. A. Gouda, Y. A. Ammar, M. S. A. El-Gaby
Overview on the synthetic routes to nicotine nitriles
Synthetic Communications 48(4), 345, 2018
DOI: 10.1080/00397911.2017.1394468
[3]. Moustafa A. Gouda, Ehab Attia, Mohamed H. Helal, Mohammed A. Salem
Recent Progress on Nicotinonitrile Scaffold-based Anticancer, Antitumor, and Antimicrobial Agents: A Literature Review
Journal of Heterocyclic Chemistry 55(10), 2224, 2018
DOI: 10.1002/jhet.3298
[4]. Reda Mohammed Keshk, Batoul Mohamed Izzularab
Design, Synthesis and Biological Evaluation of Cyanopyridines, Pyridopyrazolopyrimidines and Pyridopyrazolotriazines as Potential Anticancer Agents
Current Organic Synthesis 18(5), 483, 2021
DOI: 10.2174/1570179417666201229163045
[5]. Moustafa A. Gouda, Moged A. Berghot, Ghada E. Abd El-Ghani, Abd El-Galil M. Khalil
Synthesis of Some Novel 4-(Furan-2-yl)-5,6-dimethylpyridines
Journal of Heterocyclic Chemistry 55(8), 1935, 2018
DOI: 10.1002/jhet.3231
[6]. Moustafa A. Gouda, Ghada E. Abd El‐Ggani, Moged A. Berghot, Abd El‐Galil M. Khalil
Synthesis and Antioxidant Activity of Some Novel Nicotinonitrile Derivatives Bearing a Furan Moiety
Journal of Heterocyclic Chemistry 56(7), 2036, 2019
DOI: 10.1002/jhet.3584
[7]. Wafaa S. Hamama, Moustafa A. Gouda, Hadwah A. Kamal El‐din, Hanafi H. Zoorob
Highlights on the synthesis of novel phenothiazine‐based azines scaffold as antioxidant agents
Journal of Heterocyclic Chemistry 57(1), 257, 2020
DOI: 10.1002/jhet.3771
[8]. Moustafa A. Gouda, Belal H. M. Hussein, Mohamed H. Helal, Mohammed A. Salem
A Review: Synthesis and Medicinal Importance of Nicotinonitriles and Their Analogous
Journal of Heterocyclic Chemistry 55(7), 1524, 2018
DOI: 10.1002/jhet.3188
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DOI Link: https://doi.org/10.5155/eurjchem.6.1.84-87.1149
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European Journal of Chemistry 2015, 6(1), 84-87 | doi: https://doi.org/10.5155/eurjchem.6.1.84-87.1149 | Get rights and content
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