European Journal of Chemistry 2015, 6(2), 117-126. doi:10.5155/eurjchem.6.2.117-126.1172

Synthesis, characterization, DNA-binding and biological activity of Zn(II) complexes of sulfadiazine with different amino acids


Ahmed Abdlmonem El-Henawy (1) , Ahmed Imam Hanafy (2,*)

(1) Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, 11884, Egypt
(2) Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, 11884, Egypt
(*) Corresponding Author

Received: 19 Oct 2014, Accepted: 18 Jan 2015, Published: 30 Jun 2015

Abstract


New Zn(II) complexes (ZnII-VS, ZnII-LS, ZnII-SS, ZnII-CS and ZnII-MS) of the sulfonamide antibiotic sulfadiazine with different amino acids were prepared and fully characterized by elemental analyses, thermal analysis and IR, UV/Vis and 1H NMR spectroscopy. The IR and 1H NMR spectral data show that the ligands behave in a dibasic bidentate fashion coordinating to zinc ion. Interactions of these complexes with DNA were investigated by spectrophotometric method. Moreover, the antibacterial and antifungal activities were evaluated for five ligands and their complexes. The computational study for prediction of absorption, distribution, metabolism, elimination and toxic factors (ADMET) properties were performed for the prepared ligands.


Keywords


Docking; Antifungal; Amino acid, Sulfadiazine; DNA-binding; Antibacterial activity

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DOI: 10.5155/eurjchem.6.2.117-126.1172

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How to cite


El-Henawy, A.; Hanafy, A. Eur. J. Chem. 2015, 6(2), 117-126. doi:10.5155/eurjchem.6.2.117-126.1172
El-Henawy, A.; Hanafy, A. Synthesis, characterization, DNA-binding and biological activity of Zn(II) complexes of sulfadiazine with different amino acids. Eur. J. Chem. 2015, 6(2), 117-126. doi:10.5155/eurjchem.6.2.117-126.1172
El-Henawy, A., & Hanafy, A. (2015). Synthesis, characterization, DNA-binding and biological activity of Zn(II) complexes of sulfadiazine with different amino acids. European Journal of Chemistry, 6(2), 117-126. doi:10.5155/eurjchem.6.2.117-126.1172
El-Henawy, Ahmed, & Ahmed Imam Hanafy. "Synthesis, characterization, DNA-binding and biological activity of Zn(II) complexes of sulfadiazine with different amino acids." European Journal of Chemistry [Online], 6.2 (2015): 117-126. Web. 23 Oct. 2019
El-Henawy, Ahmed, AND Hanafy, Ahmed. "Synthesis, characterization, DNA-binding and biological activity of Zn(II) complexes of sulfadiazine with different amino acids" European Journal of Chemistry [Online], Volume 6 Number 2 (30 June 2015)

DOI Link: https://doi.org/10.5155/eurjchem.6.2.117-126.1172

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