European Journal of Chemistry

Synthesis, antimicrobial activity, computational and modeling studies of some new organotellurium compounds containing azo moities

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Published: Dec 31, 2015
DOI: https://doi.org/10.5155/eurjchem.6.4.374-380.1254
Keywords:
LANL2DZ, Telluration, Azo compounds, 8-Hydroxyquinoline, Antimicrobial activity, Computational and modeling studies
Section
Research Article
Issue
Vol. 6 No. 4 (2015): December 2015
Dates


Main Article Content

Wasfi Aboud Al-Masoudi
Department of Physiology and Chemistry, College of Veterinary, University of Basrah, Basrah, 61001, Iraq
Rafid Hmedan Al-Asadi
Department of Chemistry, College of Education for Pure Sciences, University of Basrah, 61001, Basrah, Iraq
Rasha Munther Othman
Department of Microbiology, College of Veterinary, University of Basrah, Basrah 61001, Iraq
Najim Aboud Al‐Masoudi
Department of Chemistry, College of Science, University of Basrah, Basrah, 61001, Iraq

Abstract

A new series of organonotellurium compounds containing azo groups were prepared by new and convenient methods. Reaction of 1-(4-mercuric chloride-2,3-dichlorophenyl)-2-chloro diazine (4) with 8-hydroxyquinoline (5) gave the new organomercury compound 6 in good yield. Telluratio of compound 6 with tellurium tetrabromide in 1:1 and 1:2 mole ratio gave the o-tellurated azo compounds ArTeBr3 (7) and Ar2TeBr2 (9), respectively. Reduction of both ArTeBr3 and Ar2TeBr2 by hydrazine hydrate gave the ditelluride 8, and telluride 10, respectively. The synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Klebsiella pneumonia, Salmonella spp., Streptococcus spp. and Bacillus cereus. Additionally, the prepared compounds were tested for antifungal activity against Candida sp., Aspergillus multi and Aspergillus niger. All compounds exhibited good antibacterial and antifungal activity. Computational study of the new compounds was calculated using Gaussian 09 program package. Molecular modeling studies were performed and showed hydrogen binding and hydrophobic interactions.


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Al-Masoudi, W. A.; Al-Asadi, R. H.; Othman, R. M.; Al‐Masoudi, N. A. Synthesis, Antimicrobial Activity, Computational and Modeling Studies of Some New Organotellurium Compounds Containing Azo Moities. Eur. J. Chem. 2015, 6, 374-380.

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