European Journal of Chemistry 2015, 6(4), 374-380 | doi: | Get rights and content

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Synthesis, antimicrobial activity, computational and modeling studies of some new organotellurium compounds containing azo moities

Wasfi Aboud Al-Masoudi (1,*) , Rafid Hmedan Al-Asadi (2) , Rasha Munther Othman (3) , Najim Aboud Al‐Masoudi (4)

(1) Department of Physiology and Chemistry, College of Veterinary, University of Basrah, Basrah, 61001, Iraq
(2) Department of Chemistry, College of Education for Pure Sciences, University of Basrah, 61001, Basrah, Iraq
(3) Department of Microbiology, College of Veterinary, University of Basrah, Basrah 61001, Iraq
(4) Department of Chemistry, College of Science, University of Basrah, Basrah, 61001, Iraq
(*) Corresponding Author

Received: 07 Feb 2015 | Accepted: 28 Mar 2015 | Published: 31 Dec 2015 | Issue Date: December 2015


A new series of organonotellurium compounds containing azo groups were prepared by new and convenient methods. Reaction of 1-(4-mercuric chloride-2,3-dichlorophenyl)-2-chloro diazine (4) with 8-hydroxyquinoline (5) gave the new organomercury compound 6 in good yield. Telluratio of compound 6 with tellurium tetrabromide in 1:1 and 1:2 mole ratio gave the o-tellurated azo compounds ArTeBr3 (7) and Ar2TeBr2 (9), respectively. Reduction of both ArTeBr3 and Ar2TeBr2 by hydrazine hydrate gave the ditelluride 8, and telluride 10, respectively. The synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Klebsiella pneumonia, Salmonella spp., Streptococcus spp. and Bacillus cereus. Additionally, the prepared compounds were tested for antifungal activity against Candida sp., Aspergillus multi and Aspergillus niger. All compounds exhibited good antibacterial and antifungal activity. Computational study of the new compounds was calculated using Gaussian 09 program package. Molecular modeling studies were performed and showed hydrogen binding and hydrophobic interactions.


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European Journal of Chemistry


LANL2DZ; Telluration; Azo compounds; 8-Hydroxyquinoline; Antimicrobial activity; Computational and modeling studies

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DOI: 10.5155/eurjchem.6.4.374-380.1254

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Departments of Physiology and Microbiology, College of Veterinary Medicine, Basrah University, Iraq



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How to cite

Al-Masoudi, W.; Al-Asadi, R.; Othman, R.; Al‐Masoudi, N. Eur. J. Chem. 2015, 6(4), 374-380. doi:10.5155/eurjchem.6.4.374-380.1254
Al-Masoudi, W.; Al-Asadi, R.; Othman, R.; Al‐Masoudi, N. Synthesis, antimicrobial activity, computational and modeling studies of some new organotellurium compounds containing azo moities. Eur. J. Chem. 2015, 6(4), 374-380. doi:10.5155/eurjchem.6.4.374-380.1254
Al-Masoudi, W., Al-Asadi, R., Othman, R., & Al‐Masoudi, N. (2015). Synthesis, antimicrobial activity, computational and modeling studies of some new organotellurium compounds containing azo moities. European Journal of Chemistry, 6(4), 374-380. doi:10.5155/eurjchem.6.4.374-380.1254
Al-Masoudi, Wasfi, Rafid Hmedan Al-Asadi, Rasha Munther Othman, & Najim Aboud Al‐Masoudi. "Synthesis, antimicrobial activity, computational and modeling studies of some new organotellurium compounds containing azo moities." European Journal of Chemistry [Online], 6.4 (2015): 374-380. Web. 26 Sep. 2023
Al-Masoudi, Wasfi, Al-Asadi, Rafid, Othman, Rasha, AND Al‐Masoudi, Najim. "Synthesis, antimicrobial activity, computational and modeling studies of some new organotellurium compounds containing azo moities" European Journal of Chemistry [Online], Volume 6 Number 4 (31 December 2015)

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