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Spectrofluorimetric determination of Bisoprolol fumarate and Rosuvastatin calcium in a novel combined formulation and in human spiked plasma
Nada Sayed Abdelwahab (1)
, Nouruddin Wageh Ali (2) , Marco Mounir Zaki (3,*) , Adel Ahmed Ali (4) , Mohamed Mohamed Abdelkawy (5) (1) Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt
(2) Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt
(3) Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt
(4) Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt
(5) Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
(*) Corresponding Author
Received: 03 Jun 2018 | Revised: 08 Aug 2018 | Accepted: 10 Aug 2018 | Published: 31 Dec 2018 | Issue Date: December 2018
Abstract
Sensitive, simple and rapid spectrofluorimetric method was developed for simultaneous determination of bisoprolol fumarate (BIS) and rosuvastatin calcium (ROS) in novel formulated tablets and in human spiked plasma depending on measuring their native fluorescence. The fluorescence intensity of BIS and ROS were measured in methanol at emission wavelength of 297 and 485 nm upon excitation at 227 and 242 nm, respectively. The emission spectrum of each drug reveals zero value at the emission wavelength of the other drug, thus allowing their simultaneous determination without any interference and without using any tedious derivatization steps. Excellent linearity was obtained over the range of 10-500 and 20-1000 ng/mL for BIS and ROS, respectively. The developed method was evaluated by applying to laboratory prepared mixtures and pharmaceutical formulation. The high sensitivity of the method was the motivation to its application for analysis of the cited drugs in spiked human plasma. Likewise, analytical and bioanalytical method validation was carried out following International Conference on Harmonisation guidelines and also statistical analysis with the reported methods was carried out and no significant difference was found. The developed method is the first developed spectrofluorimetric method for simultaneous determination of the newly formulated drugs.
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DOI: 10.5155/eurjchem.9.4.331-337.1753
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Citations
[1]. Shrouk M. Abo Elkheir, Abdallah M. Zeid, Jenny Jeehan M. Nasr, Mohamed I. Walash
First derivative synchronous spectrofluorimetric analysis of bisoprolol fumarate and ivabradine in pharmaceutical and biological matrices. Investigation of the method greenness
Luminescence 37(10), 1657, 2022
DOI: 10.1002/bio.4337
[2]. Marco Mounir Zaki, Nada Sayed Abdelwahab, Adel Ahmed Ali, Souty Mounie Zaki Sharkawi
Simultaneous determination of bisoprolol fumarate and rosuvastatin calcium in a new combined formulation by validated RP-HPLC
European Journal of Chemistry 10(1), 52, 2019
DOI: 10.5155/eurjchem.10.1.52-56.1815
[3]. Ahmed M. Abdel‐Megied, Sergiy Kovalenko, Fawzy A. Elbarbry, Marjan Piponski, Oleksandra Oleshchuk, Sami El Deeb, Galal Magdy, Fathalla Belal, Taras Grochovuy, Liliya Logoyda
LC–MS/MS bioanalytical method for the quantitative analysis of nifedipine, bisoprolol, and captopril in human plasma: Application to pharmacokinetic studies
Biomedical Chromatography , , 2023
DOI: 10.1002/bmc.5664
[4]. Berna Koçak, Yeliz İpek
Nafion–Titanium (IV) Oxide-Graphene Modified Glassy Carbon Electrode (GCE) Based Electrochemical Sensor for the Voltammetric Determination of the β-blocker Bisoprolol Fumarate
Analytical Letters 56(10), 1619, 2023
DOI: 10.1080/00032719.2022.2139837
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DOI Link: https://doi.org/10.5155/eurjchem.9.4.331-337.1753
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European Journal of Chemistry 2018, 9(4), 331-337 | doi: https://doi.org/10.5155/eurjchem.9.4.331-337.1753 | Get rights and content
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