

Zn(L-proline)2: An efficient and reusable organocatalyst for the synthesis of polyfunctionally substituted pyrans and 2-amino-4-aryl-8-oxo-4,8-dihydropyrano[3,2-b]pyran derivatives
Fatma Ahmed Abo Elsoud (1)




(1) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Deraya University, Minia 61768, Egypt
(2) Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt
(3) Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt
(4) Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt
(*) Corresponding Author
Received: 24 Mar 2019 | Revised: 19 May 2019 | Accepted: 20 May 2019 | Published: 30 Jun 2019 | Issue Date: June 2019
Abstract
Efficient synthesis of non-annulated 2-amino-4H-pyrans and 2-amino-8-oxo-4,8-dihydropyrano[3,2-b]pyran derivatives, which are biologically relevant heterocycles is achieved, utilizing a domino three-component reaction of ethyl acetoacetate or kojic acid with aromatic aldehydes and malononitrile catalyzed by Zn(L-proline)2 as reusable organometallic catalyst. The process exhibits high atom economy, short reaction time, simple work up, high yields and environmentally friendly nature. Excellent yields of the targeted molecules have been obtained.
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DOI: 10.5155/eurjchem.10.2.166-170.1851
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Deraya University, Minia 61768, Egypt
Citations
[1]. Morteza Ziyaadini, Nabi Nemat-Bakhsh, Seyyed Jalal Roudbaraki, Majid Ghashang
Zn2SnO4-SnO2 Nano-Composite Promoted Ultrasonic-Assisted Synthesis of Pyran Derivatives
Polycyclic Aromatic Compounds 42(2), 460, 2022
DOI: 10.1080/10406638.2020.1743328

[2]. Kamal Usef Sadek, Ramadan Ahmed Mekheimer, Mohamed Abd‐Elmonem, Mohamed Hilmy Elnagdi
Recent developments in the utility of Zn(L‐proline)2 as benign and recyclable metallo‐organocatalyst in organic synthesis
Applied Organometallic Chemistry 34(2), , 2020
DOI: 10.1002/aoc.5315

[3]. Mohammad Suhail, Sofi Danish Mukhtar, Imran Ali, Ariba Ansari, Saiyam Arora
Theoretical DFT study of Cannizzaro reaction mechanism: A mini perspective
European Journal of Chemistry 11(2), 139, 2020
DOI: 10.5155/eurjchem.11.2.139-144.1975

[4]. Anupam Sarkar, Subhradeep Mistry, Srinivasan Natarajan
Friedländer, Knoevenagel, and Michael Reactions Employing the Same MOF: Synthesis, Structure, and Heterogeneous Catalytic Studies of ([Zn(1,4-NDCA)(3-BPDB)0.5]·(DMF)(MeOH) and [Cd4(1,4-NDCA)4(3-BPDB)4]·2(DMF)
The Journal of Physical Chemistry C 125(49), 27230, 2021
DOI: 10.1021/acs.jpcc.1c08474

[5]. Biplob Borah, Kartikey Dhar Dwivedi, L. Raju Chowhan
Review on Synthesis and Medicinal Application of Dihydropyrano[3,2-b]Pyrans and Spiro-Pyrano[3,2-b]Pyrans by Employing the Reactivity of 5-Hydroxy-2-(Hydroxymethyl)-4H-Pyran-4-One
Polycyclic Aromatic Compounds 42(9), 5893, 2022
DOI: 10.1080/10406638.2021.1962923

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