European Journal of Chemistry

Zn(L-proline)2: An efficient and reusable organocatalyst for the synthesis of polyfunctionally substituted pyrans and 2-amino-4-aryl-8-oxo-4,8-dihydropyrano[3,2-b]pyran derivatives


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Fatma Ahmed Abo Elsoud
Mohamed Abd-Elmonem
Mohamed Abo Elsebaa
Kamal Usef Sadek


Efficient synthesis of non-annulated 2-amino-4H-pyrans and 2-amino-8-oxo-4,8-dihydropyrano[3,2-b]pyran derivatives, which are biologically relevant heterocycles is achieved, utilizing a domino three-component reaction of ethyl acetoacetate or kojic acid with aromatic aldehydes and malononitrile catalyzed by Zn(L-proline)2 as reusable organometallic catalyst. The process exhibits high atom economy, short reaction time, simple work up, high yields and environmentally friendly nature. Excellent yields of the targeted molecules have been obtained.

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Abo Elsoud, F. A.; Abd-Elmonem, M.; Abo Elsebaa, M.; Sadek, K. U. Zn(L-proline)2: An Efficient and Reusable Organocatalyst for the Synthesis of Polyfunctionally Substituted Pyrans and 2-Amino-4-Aryl-8-Oxo-4,8-dihydropyrano[3,2-b]pyran Derivatives. Eur. J. Chem. 2019, 10, 166-170.

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Deraya University, Minia 61768, Egypt

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