European Journal of Chemistry 2022, 13(1), 109-116 | doi: | Get rights and content

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Synthesis, antimicrobial, and antitubercular evaluation of new Schiff bases with in silico ADMET and molecular docking studies

Sakshith Raghavendra Prasad (1) orcid , Nayak Devappa Satyanarayan (2,*) orcid , Avarse Satish Kumar Shetty (3) orcid , Basaiah Thippeswamy (4) orcid

(1) Department of Pharmaceutical Chemistry, National College of Pharmacy, Balaraj Urs Road, Shivamogga-577201, Karnataka, India
(2) Department of Pharmaceutical Chemistry, Kuvempu University, Post-Graduate Centre, Kadur-577548, Karnataka, India
(3) Department of Pharmaceutical Chemistry, National College of Pharmacy, Balaraj Urs Road, Shivamogga-577201, Karnataka, India
(4) Department of Post-Graduation Studies and Research in Microbiology, Jnanasahyadri, Kuvempu University, Shankaraghatta-577451, India
(*) Corresponding Author

Received: 18 Nov 2021 | Revised: 31 Dec 2021 | Accepted: 03 Jan 2022 | Published: 31 Mar 2022 | Issue Date: March 2022


Schiff bases are a proven moiety in antitubercular drug discovery and the antitubercular drug development. Drug discovery is a never-ending process due to evolving drug resistance by the bacteria, as a result, there is a need of developing new antitubercular drugs. In this continuous process of antitubercular drug discovery, new series of Schiff bases are synthesized using quinoline carbohydrazide upon coupling with different aldehydes in ethanolic media through multistep synthesis. These synthesized compounds were purified and characterized by different spectroscopic techniques. The molecules were in vitro screened for antifungal and antibacterial potential by Agar well diffusion assay, antitubercular activity by using microplate Alamar blue assay, and an attempt has been made to study the in-silico relationship between new Schiff base derivatives 4a-f and the crystal structure of M. tuberculosis (5V3Y) protein by molecular docking studies. Synthesized compounds 4a-f show good interaction with the crystal structure of M. tuberculosis protein (5V3Y) and fulfill ADMET characteristics in silico experiments. Among the compounds tested, compound 4d was found to be active against bacteria and fungi. Compound 4b was found to be sensitive against M. tuberculosis at 50 µg/mL concentration.


5V3Y; MABA; In silico; Antifungal activity; Multistep synthesis; Antibacterial activity

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DOI: 10.5155/eurjchem.13.1.109-116.2216

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Kuvempu University, Shankaraghatta-577451, India.


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How to cite

Prasad, S.; Satyanarayan, N.; Shetty, A.; Thippeswamy, B. Eur. J. Chem. 2022, 13(1), 109-116. doi:10.5155/eurjchem.13.1.109-116.2216
Prasad, S.; Satyanarayan, N.; Shetty, A.; Thippeswamy, B. Synthesis, antimicrobial, and antitubercular evaluation of new Schiff bases with in silico ADMET and molecular docking studies. Eur. J. Chem. 2022, 13(1), 109-116. doi:10.5155/eurjchem.13.1.109-116.2216
Prasad, S., Satyanarayan, N., Shetty, A., & Thippeswamy, B. (2022). Synthesis, antimicrobial, and antitubercular evaluation of new Schiff bases with in silico ADMET and molecular docking studies. European Journal of Chemistry, 13(1), 109-116. doi:10.5155/eurjchem.13.1.109-116.2216
Prasad, Sakshith, Nayak Devappa Satyanarayan, Avarse Satish Kumar Shetty, & Basaiah Thippeswamy. "Synthesis, antimicrobial, and antitubercular evaluation of new Schiff bases with in silico ADMET and molecular docking studies." European Journal of Chemistry [Online], 13.1 (2022): 109-116. Web. 22 Mar. 2023
Prasad, Sakshith, Satyanarayan, Nayak, Shetty, Avarse, AND Thippeswamy, Basaiah. "Synthesis, antimicrobial, and antitubercular evaluation of new Schiff bases with in silico ADMET and molecular docking studies" European Journal of Chemistry [Online], Volume 13 Number 1 (31 March 2022)

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