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Green methodologies in organic synthesis: Microwave assisted solvent- and catalyst-free synthesis of enaminones and their conversion into 1,3,5-trisubstituted benzenes as well as 3-aroyl-6-substituted pyridines
Morsy Ahmed El-Apasery (1)
, Saleh Mohamed Al-Mousawi (2,*) , Mohamed Helmy Elnagdi (3) (1) Department of Chemistry, Faculty of Science, Kuwait University, Safat, 13060, Kuwait
(2) Department of Chemistry, Faculty of Science, Kuwait University, Safat, 13060, Kuwait
(3) Department of Chemistry, Faculty of Science, Kuwait University, Safat, 13060, Kuwait
(*) Corresponding Author
Received: 03 Aug 2010, Accepted: 16 Nov 2010, Published: 30 Jun 2011
Abstract
Enaminones were obtained in good yields via condensing methyl ketones with (N,N-dimethylformamide dimethyl acetal) DMF-DMA under microwave irradiation in absence of solvent. These enaminones were readily converted into 1,3,5-trisubstituted benzenes. Reacting enaminones in presence of ammonium acetate has afforded pyridine derivatives.
Keywords
Enaminone; Solvent-free; Green chemistry; Dye intermediates; Microwave irradiation; 1,3,5-trisubstituted benzenes
DOI: 10.5155/eurjchem.2.2.168-172.228
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doi:10.1021/cr020093y
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[5]. Sheikhshoaie, I. F; Walter M. F. Curr. Org. Chem. 2009, 13(2), 149-171.
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[8]. Ghozlan S. A. S; Abdelhamid, I. A.; Gaber, H.; Elnagdi, M. H. J. Heterocycl. Chem. 2005, 42, 1185-1189.
doi:10.1002/jhet.5570420623
[9]. Al-Saleh, B.; Makhseed, S.; Hassaneen, H. M. E.; Elnagdi, M. H. Synthesis, 2006, 59-62.
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doi:10.1246/bcsj.60.3285
[11]. Braibante, M. E. F.; Braibante, H. T. S.; Rosso, G. B.; Oriques, D. A. J. Braz. Chem. Soc. 2003, 14, 994-997.
doi:10.1590/S0103-50532003000600016
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doi:10.1590/S0103-50532006000100026
[13]. Rechsteiner, B.; Texier-Boullet, F.; Hamelin, J. Tetrahedron Lett. 1993, 34, 5071-5074.
doi:10.1016/S0040-4039(00)60678-0
[14]. Lee, D. H.; Park, S. E.; Cho, K.; Kim, Y.; Athar, T.; Lee, I. M. Tetrahedron Lett. 2007, 48, 8281-8284.
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How to cite
El-Apasery, M.; Al-Mousawi, S.; Elnagdi, M.
Eur. J. Chem.
2011,
2(2), 168-172.
doi:10.5155/eurjchem.2.2.168-172.228
El-Apasery, M.; Al-Mousawi, S.; Elnagdi, M. Green methodologies in organic synthesis: Microwave assisted solvent- and catalyst-free synthesis of enaminones and their conversion into 1,3,5-trisubstituted benzenes as well as 3-aroyl-6-substituted pyridines.
Eur. J. Chem.
2011,
2(2), 168-172.
doi:10.5155/eurjchem.2.2.168-172.228
El-Apasery, M., Al-Mousawi, S., & Elnagdi, M.
(2011).
Green methodologies in organic synthesis: Microwave assisted solvent- and catalyst-free synthesis of enaminones and their conversion into 1,3,5-trisubstituted benzenes as well as 3-aroyl-6-substituted pyridines.
European Journal of Chemistry, 2(2), 168-172.
doi:10.5155/eurjchem.2.2.168-172.228
El-Apasery, Morsy, Saleh Mohamed Al-Mousawi, & Mohamed Helmy Elnagdi.
"Green methodologies in organic synthesis: Microwave assisted solvent- and catalyst-free synthesis of enaminones and their conversion into 1,3,5-trisubstituted benzenes as well as 3-aroyl-6-substituted pyridines." European Journal of Chemistry [Online], 2.2 (2011): 168-172. Web. 15 Nov. 2019
El-Apasery, Morsy, Al-Mousawi, Saleh, AND Elnagdi, Mohamed.
"Green methodologies in organic synthesis: Microwave assisted solvent- and catalyst-free synthesis of enaminones and their conversion into 1,3,5-trisubstituted benzenes as well as 3-aroyl-6-substituted pyridines" European Journal of Chemistry [Online], Volume 2 Number 2 (30 June 2011)
DOI Link: https://doi.org/10.5155/eurjchem.2.2.168-172.228
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