European Journal of Chemistry 2012, 3(3), 332-336. doi:10.5155/eurjchem.3.3.332-336.637

Conductometric titration method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl using silver nitrate


Magda Mohamed Ayad (1) , Hisham Ezzat Abdellatef (2) , Mervat Mohamed Hosny (3,*) , Yassmin Ahmed Sharaf (4)

(1) Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
(2) Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
(3) Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
(4) Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
(*) Corresponding Author

Received: 15 May 2012, Accepted: 10 Jul 2012, Published: 30 Sep 2012

Abstract


A simple, precise, rapid, and low-cost conductometric method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl in pure form and in pharmaceutical formulations using silver nitrate has been described. The method is based on the precipitation of oxalate or chloride ions coming from the cited drugs with silver ions, yielding silver oxalate or silver chloride and the conductance of the solution is measured as a function of the volume of titrant. The studied drugs were evaluated in double distilled water in the range of 1-15 mg. Various experimental conditions were established and results obtained showed good recoveries with relative standard deviation of 0.909, 0.955 and 0.983 for naftidrofuryl, propafenone and sotalol, respectively. The proposed procedures were applied successfully to the analysis of these drugs in their pharmaceutical formulations. Results were favorably comparable to the official or reference methods.

3_3_332_336_800


Keywords


Oxalate; Sotalol HCl; Silver nitrate; Propafenone HCl; Naftidrofuryl oxalate; Conductometric titration

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DOI: 10.5155/eurjchem.3.3.332-336.637

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References

[1]. The British Pharmacopoeia, Volumes II and III, Her Majesty’s Stationery Office, London, UK, 2008.

[2]. Sweetman, S. C. Martindale-The Complete Drug Reference, 35th edition, The Pharmaceutical Press, London, 2007.

[3]. Belal, T. S.; Barary, M. H.; Sabry, S. M.; Ibrahim, M. A. J. Food Drug Anal. 2009, 17, 415-423.

[4]. Sabry, S. M.; Belal, T. S.; Barary, M. H.; Ibrahim, M. A. Int. J. Biomed. Sci. 2009, 5, 283-292.

[5]. Walmsley, L. M.; Wilkinson, P. A.; Brodie, R. R.; Chasseaud, L. F. J. Chromatogr. 1985, 338, 433-437.
http://dx.doi.org/10.1016/0378-4347(85)80117-1

[6]. Waaler, P. J.; Mueller, B. W. Int. J. Pharm. 1992, 87, 223-227.
http://dx.doi.org/10.1016/0378-5173(92)90246-X

[7]. Brodie, R. R.; Chasseaud, L. F.; Taylor, T. J. Chromatogr. 1979, 164, 534-540.
http://dx.doi.org/10.1016/S0378-4347(00)81559-5

[8]. Garrett, E. R.; Barbhaiya, R.; J. Pharm. Sci. 1981, 70, 39-45.
http://dx.doi.org/10.1002/jps.2600700106
PMid:7229928

[9]. Munoz, A.; Espinosa, A.; Murillo, J. A. Analyst 1998, 123, 2285-2290.
http://dx.doi.org/10.1039/a804632h

[10]. Murillo, A.; Alanon, A.; Fernandez, P. Anal. Chim. Acta 1999, 382, 77-85.
http://dx.doi.org/10.1016/S0003-2670(98)00793-4

[11]. Segura, A.; Cruces, C.; Canabate, B. Anal.C him. Acta 2000, 417, 19-30.
http://dx.doi.org/10.1016/S0003-2670(00)00917-X

[12]. Cruces, C.; Segura, A.; Fernandez, J. F.; Fernandez, A. J. Pharm. Biomed. Anal. 2000, 23, 845-850.
http://dx.doi.org/10.1016/S0731-7085(00)00391-5

[13]. Ionescu, M. S.; Badea, V.; Baiulescu, G. E.; Cosofret, V. V. Talanta 1986, 33, 101-103.
http://dx.doi.org/10.1016/0039-9140(86)80021-2

[14]. Fernandez-Sanchez, J. F.; Segura-Carretero, A.; Cruces-Blanco, C.; Fernandez-Gutierrez, A. Anal. Chim. Acta 2002, 462, 217-224.
http://dx.doi.org/10.1016/S0003-2670(02)00348-3

[15]. United States Pharmacopoeia, XXIV, United States Pharmacopoeia Convention, Washington, DC, 2007.

[16]. Dhandapani, B.; Keerthi, J.; Babunaik, M.; Lavanya, L.; Priyamvadha, D. L.; Manjeera, K. K; Anusha, B. H.; Celestin Baboo, R. V. Int. J. Pharm. Biomed. Res. 2010, 1, 49-53.

[17]. El-Dawy, M. A.; Mabrouk, M. M.; EL Barbary R. A. Chem. Pharm. Bull. 2006, 54, 1026-1029.

[18]. Li, G. B.; Lin, X. L.; Zhu, C. F.; Hao, A. Y.; Guan, Y. F. Anal. Chim. Acta 2000, 421, 27-34.
http://dx.doi.org/10.1016/S0003-2670(00)00960-0

[19]. Chankvetadze, B.; Lomsadze, K.; Blaschke, G. J. Sep. Sci. 2001, 24, 795-801.
http://dx.doi.org/10.1002/1615-9314(20010901)24:9<795::AID-JSSC795>3.0.CO;2-V

[20]. Brode, E.; Kripp, U.; Hollmann, M. Arznei. Forschung 1984, 34, 1455-1460.
PMid:6151841

[21]. Brode, E.; Kripp, U.; Breckwoldt, W. Methods 1988, 10, 319-329.

[22]. Afshar, M.; Rouini, M. Anal. Sci. 2004, 20, 1307-1311.
http://dx.doi.org/10.2116/analsci.20.1307
PMid:15478341

[23]. Lamprecht, G.; Stoschitzky, K. J. Chromatogr. B 2009, 877, 3489-3494.
http://dx.doi.org/10.1016/j.jchromb.2009.08.024
PMid:19736049

[24]. Buszewski, B.; Nowaczyk, J.; Ligor, T.; Olszowy, P.; Ligor, M.; Wasiniak, B.; Miekisch, W.; Schubert, J. K.; Amann, A. J. Sep. Sci. 2009, 32, 2448-2454.
http://dx.doi.org/10.1002/jssc.200900094
PMid:19569094

[25]. Sultan, S. M.; Bukhari, A. M.; Perzanowski, H. J. Pharmaceut. Biomed. 1990, 8, 569-571.
http://dx.doi.org/10.1016/0731-7085(90)80081-Y

[26]. Banerjee, S. K.; Mashru, R. Indian J. Pharm. Sci. 1991, 53, 243-244.

[27]. Wang, W.; Zhao, G.; Cheng, X.; Jiang, W. J. Shandong Medical University 2001, 39, 215-217.

[28]. Amin, A. S.; Ragab, G. H.; Saleh, H. J. Pharmaceut. Biomed. 2002, 30, 1347-1353.
http://dx.doi.org/10.1016/S0731-7085(02)00205-4

[29]. Santoro, M. I. R. M.; Tsubone, C.; Gomes, F. P.; Kedor-Hackmann, E. R. M.; Garcia, P. G. Anal. Lett. 2008, 41, 2044-2057.
http://dx.doi.org/10.1080/00032710802209342

[30]. Garrett, E. R.; Schnelle, K. J. Pharm. Sci. 1971, 60, 833-839.
http://dx.doi.org/10.1002/jps.2600600607
PMid:4399660

[31]. Zhang, H.; Yang, J.; Du, L.; Li, C.; Wu, H. Anal. Methods 2011, 3, 1156-1162.
http://dx.doi.org/10.1039/c0ay00728e

[32]. Stephanie, S.; Wauer, I.; Scholz, H. J. Chromatogr. B 2001, 753, 421-425.
http://dx.doi.org/10.1016/S0378-4347(00)00562-4

[33]. Rbeida, O.; Christiaens, B.; Chiap, P.; Hubert, P.; Lubda, D.; Boos, K.; Crommen, J. Pharmaceut. Biomed. 2003, 32, 829-838.
http://dx.doi.org/10.1016/S0731-7085(03)00186-9

[34]. Dogrukol-Ak, D.; Dal, A., G.; Tuncel, M. Chromatographia 2007, 66, 159-163.
http://dx.doi.org/10.1365/s10337-007-0312-9

[35]. Iorio, M. A.; Mazzeo-Farina, A.; Doldo, A. J. Pharmaceut. Biomed. 1987, 5, 1-10.
http://dx.doi.org/10.1016/0731-7085(87)80002-X

[36]. Belal, F.; Rizk, F. A.; El-Enany, N. M, Chem. Anal. 1999, 44, 763-772.

[37]. Sartori, E. R.; Suarez, W. T.; Fatibello-Filho, O. Quim. Nova 2009, 32, 1947-1950.
http://dx.doi.org/10.1590/S0100-40422009000700043

[38]. Fabio, R. C.; Ava, G.; Marcio, F. B.; Luiz, H. M. Curr. Pharm. Anal. 2011, 7, 275-279.

[39]. Lingane, J. J. Electroanalytical Chemistry, 2nd Ed., Interscience, New York, 90, 1958.


How to cite


Ayad, M.; Abdellatef, H.; Hosny, M.; Sharaf, Y. Eur. J. Chem. 2012, 3(3), 332-336. doi:10.5155/eurjchem.3.3.332-336.637
Ayad, M.; Abdellatef, H.; Hosny, M.; Sharaf, Y. Conductometric titration method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl using silver nitrate. Eur. J. Chem. 2012, 3(3), 332-336. doi:10.5155/eurjchem.3.3.332-336.637
Ayad, M., Abdellatef, H., Hosny, M., & Sharaf, Y. (2012). Conductometric titration method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl using silver nitrate. European Journal of Chemistry, 3(3), 332-336. doi:10.5155/eurjchem.3.3.332-336.637
Ayad, Magda, Hisham Ezzat Abdellatef, Mervat Mohamed Hosny, & Yassmin Ahmed Sharaf. "Conductometric titration method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl using silver nitrate." European Journal of Chemistry [Online], 3.3 (2012): 332-336. Web. 11 Nov. 2019
Ayad, Magda, Abdellatef, Hisham, Hosny, Mervat, AND Sharaf, Yassmin. "Conductometric titration method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl using silver nitrate" European Journal of Chemistry [Online], Volume 3 Number 3 (30 September 2012)

DOI Link: https://doi.org/10.5155/eurjchem.3.3.332-336.637

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