European Journal of Chemistry

Conductometric titration method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl using silver nitrate

Main Article Content

Magda Mohamed Ayad
Hisham Ezzat Abdellatef
Mervat Mohamed Hosny
Yassmin Ahmed Sharaf


A simple, precise, rapid, and low-cost conductometric method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl in pure form and in pharmaceutical formulations using silver nitrate has been described. The method is based on the precipitation of oxalate or chloride ions coming from the cited drugs with silver ions, yielding silver oxalate or silver chloride and the conductance of the solution is measured as a function of the volume of titrant. The studied drugs were evaluated in double distilled water in the range of 1-15 mg. Various experimental conditions were established and results obtained showed good recoveries with relative standard deviation of 0.909, 0.955 and 0.983 for naftidrofuryl, propafenone and sotalol, respectively. The proposed procedures were applied successfully to the analysis of these drugs in their pharmaceutical formulations. Results were favorably comparable to the official or reference methods.


icon graph This Abstract was viewed 2451 times | icon graph Article PDF downloaded 937 times

How to Cite
Ayad, M. M.; Abdellatef, H. E.; Hosny, M. M.; Sharaf, Y. A. Conductometric Titration Method for Determination of Naftidrofuryl Oxalate, Propafenone HCl and Sotalol HCl Using Silver Nitrate. Eur. J. Chem. 2012, 3, 332-336.

Article Details

Crossref - Scopus - Google - European PMC

[1]. The British Pharmacopoeia, Volumes II and III, Her Majesty’s Stationery Office, London, UK, 2008.

[2]. Sweetman, S. C. Martindale-The Complete Drug Reference, 35th edition, The Pharmaceutical Press, London, 2007.

[3]. Belal, T. S.; Barary, M. H.; Sabry, S. M.; Ibrahim, M. A. J. Food Drug Anal. 2009, 17, 415-423.

[4]. Sabry, S. M.; Belal, T. S.; Barary, M. H.; Ibrahim, M. A. Int. J. Biomed. Sci. 2009, 5, 283-292.

[5]. Walmsley, L. M.; Wilkinson, P. A.; Brodie, R. R.; Chasseaud, L. F. J. Chromatogr. 1985, 338, 433-437.

[6]. Waaler, P. J.; Mueller, B. W. Int. J. Pharm. 1992, 87, 223-227.

[7]. Brodie, R. R.; Chasseaud, L. F.; Taylor, T. J. Chromatogr. 1979, 164, 534-540.

[8]. Garrett, E. R.; Barbhaiya, R.; J. Pharm. Sci. 1981, 70, 39-45.

[9]. Munoz, A.; Espinosa, A.; Murillo, J. A. Analyst 1998, 123, 2285-2290.

[10]. Murillo, A.; Alanon, A.; Fernandez, P. Anal. Chim. Acta 1999, 382, 77-85.

[11]. Segura, A.; Cruces, C.; Canabate, B. Anal.C him. Acta 2000, 417, 19-30.

[12]. Cruces, C.; Segura, A.; Fernandez, J. F.; Fernandez, A. J. Pharm. Biomed. Anal. 2000, 23, 845-850.

[13]. Ionescu, M. S.; Badea, V.; Baiulescu, G. E.; Cosofret, V. V. Talanta 1986, 33, 101-103.

[14]. Fernandez-Sanchez, J. F.; Segura-Carretero, A.; Cruces-Blanco, C.; Fernandez-Gutierrez, A. Anal. Chim. Acta 2002, 462, 217-224.

[15]. United States Pharmacopoeia, XXIV, United States Pharmacopoeia Convention, Washington, DC, 2007.

[16]. Dhandapani, B.; Keerthi, J.; Babunaik, M.; Lavanya, L.; Priyamvadha, D. L.; Manjeera, K. K; Anusha, B. H.; Celestin Baboo, R. V. Int. J. Pharm. Biomed. Res. 2010, 1, 49-53.

[17]. El-Dawy, M. A.; Mabrouk, M. M.; EL Barbary R. A. Chem. Pharm. Bull. 2006, 54, 1026-1029.

[18]. Li, G. B.; Lin, X. L.; Zhu, C. F.; Hao, A. Y.; Guan, Y. F. Anal. Chim. Acta 2000, 421, 27-34.

[19]. Chankvetadze, B.; Lomsadze, K.; Blaschke, G. J. Sep. Sci. 2001, 24, 795-801.<795::AID-JSSC795>3.0.CO;2-V

[20]. Brode, E.; Kripp, U.; Hollmann, M. Arznei. Forschung 1984, 34, 1455-1460.

[21]. Brode, E.; Kripp, U.; Breckwoldt, W. Methods 1988, 10, 319-329.

[22]. Afshar, M.; Rouini, M. Anal. Sci. 2004, 20, 1307-1311.

[23]. Lamprecht, G.; Stoschitzky, K. J. Chromatogr. B 2009, 877, 3489-3494.

[24]. Buszewski, B.; Nowaczyk, J.; Ligor, T.; Olszowy, P.; Ligor, M.; Wasiniak, B.; Miekisch, W.; Schubert, J. K.; Amann, A. J. Sep. Sci. 2009, 32, 2448-2454.

[25]. Sultan, S. M.; Bukhari, A. M.; Perzanowski, H. J. Pharmaceut. Biomed. 1990, 8, 569-571.

[26]. Banerjee, S. K.; Mashru, R. Indian J. Pharm. Sci. 1991, 53, 243-244.

[27]. Wang, W.; Zhao, G.; Cheng, X.; Jiang, W. J. Shandong Medical University 2001, 39, 215-217.

[28]. Amin, A. S.; Ragab, G. H.; Saleh, H. J. Pharmaceut. Biomed. 2002, 30, 1347-1353.

[29]. Santoro, M. I. R. M.; Tsubone, C.; Gomes, F. P.; Kedor-Hackmann, E. R. M.; Garcia, P. G. Anal. Lett. 2008, 41, 2044-2057.

[30]. Garrett, E. R.; Schnelle, K. J. Pharm. Sci. 1971, 60, 833-839.

[31]. Zhang, H.; Yang, J.; Du, L.; Li, C.; Wu, H. Anal. Methods 2011, 3, 1156-1162.

[32]. Stephanie, S.; Wauer, I.; Scholz, H. J. Chromatogr. B 2001, 753, 421-425.

[33]. Rbeida, O.; Christiaens, B.; Chiap, P.; Hubert, P.; Lubda, D.; Boos, K.; Crommen, J. Pharmaceut. Biomed. 2003, 32, 829-838.

[34]. Dogrukol-Ak, D.; Dal, A., G.; Tuncel, M. Chromatographia 2007, 66, 159-163.

[35]. Iorio, M. A.; Mazzeo-Farina, A.; Doldo, A. J. Pharmaceut. Biomed. 1987, 5, 1-10.

[36]. Belal, F.; Rizk, F. A.; El-Enany, N. M, Chem. Anal. 1999, 44, 763-772.

[37]. Sartori, E. R.; Suarez, W. T.; Fatibello-Filho, O. Quim. Nova 2009, 32, 1947-1950.

[38]. Fabio, R. C.; Ava, G.; Marcio, F. B.; Luiz, H. M. Curr. Pharm. Anal. 2011, 7, 275-279.

[39]. Lingane, J. J. Electroanalytical Chemistry, 2nd Ed., Interscience, New York, 90, 1958.

Supporting Agencies


Dimensions - Altmetric - scite_ - PlumX

Downloads and views


Download data is not yet available.


Metrics Loading ...
License Terms

License Terms


Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License ( By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License ( are administered by Atlanta Publishing House LLC (European Journal of Chemistry).