European Journal of Chemistry 2013, 4(3), 297-302 | doi: https://doi.org/10.5155/eurjchem.4.3.297-302.811 | Get rights and content






  OPEN ACCESS | PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS

Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl and the solubility products of their ion associates with molybdophosphoric acid


Magda Mohamed Ayad (1) , Hisham Ezzat Abdellatef (2) , Mervat Mohamed Hosny (3,*) , Nagla Abdel-Sattar Kabil (4)

(1) Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
(2) Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
(3) Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
(4) Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
(*) Corresponding Author

Received: 26 Apr 2013 | Revised: 20 Jun 2013 | Accepted: 15 Jun 2013 | Published: 30 Sep 2013 | Issue Date: September 2013

Abstract


Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl with molybdophosphoric acid as a precipitating reagent was investigated. Various experimental conditions were evaluated and results obtained showed good recoveries, (mean recovery values of 100.51, 99.68, 99.41 and relative standard deviation of 0.332, 0.404, 0.509 for sibutramine HCl, sumatriptan succinate and lomefloxacine HCl, respectively). Numerical derivatization (first and second derivative) of the data was also applied, showing more accurate results compared to classical ones. The described procedures allowed the determination of equilibrium constants those indicated high degree of completeness of the precipitation reaction. Other parameters related to ion pair complex such as solubility and solubility product were also calculated. The described procedures allowed the determination of the studied drugs in the range of 5-15 mg. The precipitate obtained by ion pairing of lomefloxacine HCl with molybdophosphoric acid was spectroscopically characterized using IR. The method was further applied successively to pharmaceutical formulations, the proposed method offering a high degree of accuracy and precision when compared to reference methods.

4_3_297_302

Keywords


Sibutramine HCl; Solubility product; Lomefloxacine HCl; Sumatriptan succinate; Molybdophosphoric acid; Conductometric determination

Full Text:

PDF /    /


DOI: 10.5155/eurjchem.4.3.297-302.811

Links for Article


| | | | |

| | | | | | |

Related Articles




Article Metrics

This Abstract was viewed 744 times | PDF Article downloaded 426 times

Funding information


Department Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Citations

/


[1]. Mohammed Wafaa Nassar, Khalid AM Attia, Ragab A Said, Ahmed El-Olemy, Mohamed A Hasan
A comparative study of different spectrophotometric methods for determination of lomefloxacin hydrochloride in the presence of its decarboxylated degradation product
Journal of Analytical & Pharmaceutical Research  7(3), , 2018
DOI: 10.15406/japlr.2018.07.00235
/


[2]. Hassan Ahmad Alhazmi, Mohammed Al Bratty
Conductometric determination of naproxen in bulk and pharmaceutical dosage form
European Journal of Chemistry  8(4), 339, 2017
DOI: 10.5155/eurjchem.8.4.339-343.1614
/


References

[1]. Sweetman, S. C. Martindale-The Complete Drug Reference, 36th edition, The Pharmaceutical Press, London, 2009.

[2]. Ariburnu, E.; Uludag, M.; Yalcinkaya, H.; Yesilada, E. J. Pharmaceut. Biomed. 2012, 64-65, 77-81.
http://dx.doi.org/10.1016/j.jpba.2012.02.004
PMid:22410500

[3]. Chorilli, M; Bonfilio, R.; Chicarelli, R. S.; Salgado, H. R. N. Anal. Method. 2011, 3, 985-990.
http://dx.doi.org/10.1039/c0ay00598c

[4]. El-Gohary, N. A.; El-Nashar, R. M.; Aboul-Enien, H. Y. Anal. Lett. 2011, 44, 241-257.
http://dx.doi.org/10.1080/00032719.2010.500760

[5]. Valarmathi, R.; Karpagam, K. S. S.; Revanthi, R. The Indian Pharm. 2004, 3, 71-72.

[6]. Maluf, D. F.; Farago, P. V.; Barreira, S. M. W.; Pedroso, C. F.; Pontarolo, R. Lat. Am. J. Pharm. 2007, 26, 909-912.

[7]. The United States Pharmacopiea 30, National Formulary 25, US Pharmacoppieal Convention, Rockville, MD, 2007.

[8]. Cheng, K. N.; Redrup, M. J.; Barrow, A.; Williams, P. N. J. Pharm. Biomed. Anal. 1998, 17, 399-408.
http://dx.doi.org/10.1016/S0731-7085(97)00220-3

[9]. Tipre, D. N.; Vavia, P. R. Indian Drugs. 1999, 36, 501-505.

[10]. Riddhi, G; Dharamsi, A. J. Drug Delivery Ther. 2013, 3, 93-97.

[11]. Sagar, K.; Alvarez, J. M. F.; Hua, C.; Smyth, M. R.; Munden, R. J. Pharmaceut. Biomed. 1992, 10, 17-21.
http://dx.doi.org/10.1016/0731-7085(92)80005-8

[12]. Ramu, B. K.; Raghubabu, K. Int. J. Appl. Biol. Pharm. Technol. 2011, 2, 86-91.

[13]. Ramu, B. K.; Raghubabu, K. Int. J. Pharm. Biomed. Sci. 2010, 1, 49-52.

[14]. Ramu, B. K.; Raghubabu, K. Int. J. Pharm. Pharm. Sci. 2011, 3, 175-178.

[15]. Ramu, B. K.; Raghubabu, K. Der Pharma Chemica 2011, 3, 223-228.

[16]. Satyanarayane, K. V. V.; Rao, P. N. E-J. Chem. 2011, 8, 269-275.

[17]. Ayad, M. M.; Abdellatef, H. E.; Hosny, M. M.; Kabil, N. A. Zag. J. Pharm. Sci. 2011, 20, 9-21.

[18]. Chitlang, S. S.; Ranjane, M.; Wankhede, S. B.; Sakarkar, D. M. Int. J. Pharm. Tech. 2009, 1, 844-851.

[19]. Sun, H.; Li, L.; Su, M. Chromatographia 2008, 67, 399-405.
http://dx.doi.org/10.1365/s10337-008-0518-5

[20]. Vilchez, J. L.; Araujo, L.; Prieto, A.; Navalon, A. J. Pharmaceut. Biomed. 2001, 26, 23-29.
http://dx.doi.org/10.1016/S0731-7085(01)00391-0

[21]. Limig, D.; Qingqin, X.; Jianmei, Y. Pharmaceut. Biomed. 2003, 33, 693-698.
http://dx.doi.org/10.1016/S0731-7085(03)00365-0

[22]. Du, L. M.; Yang, Y. Q.; Wang, Q. M. Anal. Chim. Acta 2004, 516, 237-243
http://dx.doi.org/10.1016/j.aca.2004.04.006

[23]. Geffken, D.; Salem, H. Am. J. Appl. Sci. 2006, 3, 1952-1960.
http://dx.doi.org/10.3844/ajassp.2006.1952.1960

[24]. Kaur, K.; Singh, B.; Malik, A. K. Thai J. Pharm. Sci. 2010, 34, 58-66.

[25]. Lu, J. Q.; Jin, F.; Sun, T. Q.; Zhou, X. W. Int. J. Biol. Macromol. 2007, 40, 299-304.
http://dx.doi.org/10.1016/j.ijbiomac.2006.08.010
PMid:17030362

[26]. Salem, H. Am. J. Appl. Sci. 2005, 2, 719-729.
http://dx.doi.org/10.3844/ajassp.2005.719.729

[27]. Gomes, G. C.; Salgado, H. R. N. Acta Farmaceutica Bon. 2005, 24, 406-408.

[28]. Askal, H.; Refaat, I.; Darwish, I.; Marzouq, M. Chem. Pharm. Bull. 2007, 55, 1551-1556.
http://dx.doi.org/10.1248/cpb.55.1551

[29]. Issa, Y. M.; Abdel-Gawad, F. M.; Abou-Table, M. A.; Hussein, H. M. Anal. Lett. 1997, 30, 2071-2084.
http://dx.doi.org/10.1080/00032719708001722

[30]. Amin, A. S.; Dessouki, H. A.; Agwa, I. A. Arabian J. Chem. 2008, 1, 209-215.

[31]. Suhagia, B. N.; Shah; S. A., Rathod, I. S., Patel, H. M.; Rao, Y. M. Indian J. Pharm. Sci. 2006, 68, 247-249.
http://dx.doi.org/10.4103/0250-474X.25728

[32]. Darwishm, I. A.; Sultan, M. A.; Al-Arfaj, H. A. Int. J. Res. Pharm. Sci. 2010, 1, 43-50

[33]. Elazazy, M. S.; Elmasry, M. S.; Hassan, W. S. Int. J. Electrochem. Sci. 2012, 7, 9781-9794.

[34]. Maria, S.; Dorneanu, V.; Ghimicescu, G. Talanta 1997, 24, 140-142.

[35]. Issa, Y. M.; Abdel-Ghani, N. T. Microchim. Acta 1999, 132, 83-88.
http://dx.doi.org/10.1007/PL00010077

[36]. Issa, Y. M.; Youssef, A. F. A.; Mutair, A. A. Il Farmaco 2005, 60, 541-546.
http://dx.doi.org/10.1016/j.farmac.2005.03.002
PMid:15890349

[37]. Lingane, J. J. Electroanalytical Chemistry, 2nd Edition, Interscience, New York, 1958.

[38]. Andropov, L. L. Theoretical Electrochemistry, Izdatelstvo Mir: Moscow, 1977.

[39]. Anis, S. M.; Hosny, M. M.; Abdellatef, H. E.; El- Balkiny, M. N. E-J. Chem. 2011, 8, 1784-1796.

[40]. Issa, Y. M.; Shoukry, A. F.; El-Nashar, R. M. J. Pharmaceut. Biomed. 2001, 26, 379-386.
http://dx.doi.org/10.1016/S0731-7085(01)00415-0

[41]. Ayad, M. M.; Abdellatef, H. E.; Hosny, M. M.; Kabil, N. Int. J. Pharm. Biomed. Res. 2012, 3, 121-126.

How to cite


Ayad, M.; Abdellatef, H.; Hosny, M.; Kabil, N. Eur. J. Chem. 2013, 4(3), 297-302. doi:10.5155/eurjchem.4.3.297-302.811
Ayad, M.; Abdellatef, H.; Hosny, M.; Kabil, N. Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl and the solubility products of their ion associates with molybdophosphoric acid. Eur. J. Chem. 2013, 4(3), 297-302. doi:10.5155/eurjchem.4.3.297-302.811
Ayad, M., Abdellatef, H., Hosny, M., & Kabil, N. (2013). Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl and the solubility products of their ion associates with molybdophosphoric acid. European Journal of Chemistry, 4(3), 297-302. doi:10.5155/eurjchem.4.3.297-302.811
Ayad, Magda, Hisham Ezzat Abdellatef, Mervat Mohamed Hosny, & Nagla Abdel-Sattar Kabil. "Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl and the solubility products of their ion associates with molybdophosphoric acid." European Journal of Chemistry [Online], 4.3 (2013): 297-302. Web. 24 Jan. 2020
Ayad, Magda, Abdellatef, Hisham, Hosny, Mervat, AND Kabil, Nagla. "Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl and the solubility products of their ion associates with molybdophosphoric acid" European Journal of Chemistry [Online], Volume 4 Number 3 (30 September 2013)

DOI Link: https://doi.org/10.5155/eurjchem.4.3.297-302.811

| | | | |

| | | | | |

Save to Zotero Save to Mendeley

European Journal of Chemistry 2013, 4(3), 297-302 | doi: https://doi.org/10.5155/eurjchem.4.3.297-302.811 | Get rights and content

Refbacks

  • There are currently no refbacks.




Copyright (c)




© Copyright 2019  Atlanta Publishing House LLC All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2019 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 4614 Lavista road, Tucker, GA, 30084, USA. Registered in USA.

hatay escort hatay escort corlu escort corum escort burgaz escort giresun escort aydin escort ordu escort erzincan escort hatay escort sivas escort rize escort edirne escort aksaray escort kibris escort isparta escort erzurum escort tekirdag escort usak escort urfa escort kastamonu escort kibris escort manisa escort giresun escort urfa escort nevsehir escort sivas escort yalova escort ordu escort hatay escort yalova escort amasya escort kayseri escort ordu escort maras escort canakkale escort yalova escort balikesir escort manisa escort urfa escort mugla escort trabzon escort bolu escort corlu escort diyarbakir escort isparta escort kutahya escort elazig escort erzurum escort sakarya escort afyon escort kutahya escort konya escort agri escort cesme escort sinop escort sivas escort konya escort kibris escort adapazari escort luleburgaz escort adana escort kibris escort rize escort sakarya escort alanya escort isparta escort burdur escort konya escort bitlis escort canakkale escort sivas escort amasya escort mus escort aydin escort van escort yalova escort kastamonu escort mardin escort bolu escort afyon escort sakarya escort isparta escort tokat escort trakya escort bayburt escort urfa escort mardin escort