European Journal of Chemistry 2013, 4(3), 297-302. doi:10.5155/eurjchem.4.3.297-302.811

Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl and the solubility products of their ion associates with molybdophosphoric acid


Magda Mohamed Ayad (1) , Hisham Ezzat Abdellatef (2) , Mervat Mohamed Hosny (3,*) , Nagla Abdel-Sattar Kabil (4)

(1) Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
(2) Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
(3) Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
(4) Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
(*) Corresponding Author

Received: 26 Apr 2013, Accepted: 15 Jun 2013, Published: 30 Sep 2013

Abstract


Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl with molybdophosphoric acid as a precipitating reagent was investigated. Various experimental conditions were evaluated and results obtained showed good recoveries, (mean recovery values of 100.51, 99.68, 99.41 and relative standard deviation of 0.332, 0.404, 0.509 for sibutramine HCl, sumatriptan succinate and lomefloxacine HCl, respectively). Numerical derivatization (first and second derivative) of the data was also applied, showing more accurate results compared to classical ones. The described procedures allowed the determination of equilibrium constants those indicated high degree of completeness of the precipitation reaction. Other parameters related to ion pair complex such as solubility and solubility product were also calculated. The described procedures allowed the determination of the studied drugs in the range of 5-15 mg. The precipitate obtained by ion pairing of lomefloxacine HCl with molybdophosphoric acid was spectroscopically characterized using IR. The method was further applied successively to pharmaceutical formulations, the proposed method offering a high degree of accuracy and precision when compared to reference methods.

4_3_297_302

Keywords


Sibutramine HCl; Solubility product; Lomefloxacine HCl; Sumatriptan succinate; Molybdophosphoric acid; Conductometric determination

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DOI: 10.5155/eurjchem.4.3.297-302.811

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[1]. Mohammed Wafaa Nassar, Khalid AM Attia, Ragab A Said, Ahmed El-Olemy, Mohamed A Hasan
A comparative study of different spectrophotometric methods for determination of lomefloxacin hydrochloride in the presence of its decarboxylated degradation product
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DOI: 10.15406/japlr.2018.07.00235
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[2]. Hassan Ahmad Alhazmi, Mohammed Al Bratty
Conductometric determination of naproxen in bulk and pharmaceutical dosage form
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How to cite


Ayad, M.; Abdellatef, H.; Hosny, M.; Kabil, N. Eur. J. Chem. 2013, 4(3), 297-302. doi:10.5155/eurjchem.4.3.297-302.811
Ayad, M.; Abdellatef, H.; Hosny, M.; Kabil, N. Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl and the solubility products of their ion associates with molybdophosphoric acid. Eur. J. Chem. 2013, 4(3), 297-302. doi:10.5155/eurjchem.4.3.297-302.811
Ayad, M., Abdellatef, H., Hosny, M., & Kabil, N. (2013). Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl and the solubility products of their ion associates with molybdophosphoric acid. European Journal of Chemistry, 4(3), 297-302. doi:10.5155/eurjchem.4.3.297-302.811
Ayad, Magda, Hisham Ezzat Abdellatef, Mervat Mohamed Hosny, & Nagla Abdel-Sattar Kabil. "Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl and the solubility products of their ion associates with molybdophosphoric acid." European Journal of Chemistry [Online], 4.3 (2013): 297-302. Web. 17 Sep. 2019
Ayad, Magda, Abdellatef, Hisham, Hosny, Mervat, AND Kabil, Nagla. "Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl and the solubility products of their ion associates with molybdophosphoric acid" European Journal of Chemistry [Online], Volume 4 Number 3 (30 September 2013)

DOI Link: https://doi.org/10.5155/eurjchem.4.3.297-302.811

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