European Journal of Chemistry 2013, 4(1), 35-43. doi:10.5155/eurjchem.4.1.35-43.713

Application of 4-chloro-7-nitrobenzofurazan for the analysis of propafenone and diltiazem hydrochlorides using kinetic spectrophotometric and spectrofluorimetric methods


Magda Mohamed Ayad (1) , Hisham Ezzat Abdellatef (2) , Mervat Mohamed Hosny (3,*) , Yassmin Ahmed Sharaf (4)

(1) Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
(2) Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
(3) Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
(4) Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
(*) Corresponding Author

Received: 29 Nov 2012, Accepted: 25 Dec 2012, Published: 31 Mar 2013

Abstract


Several simple, sensitive, accurate and inexpensive spectrophotometric and spectrofluorimetric methods were developed for the determination of propafenone HCl and diltiazem HCl using 4-chloro-7-nitrobenzofurazan (NBD-Cl) accompanied with kinetic study, either in pure form or in pharmaceutical preparations. In this work, the cited drugs react with (NBD-Cl) in presence of borate buffer of pH = 7.6 at a fixed time of 30 minutes on thermostated water bath at (75-80 °C). The absorbance was measured using spectrophotometric technique at 489 and 481 nm for propafenone HCl and diltiazem HCl, respectively, or by using spectrofluorimetric technique after dilution at the specific wavelength of excitation and emission.The calibration curves were linear in the range of 4-44, 16-96 µg/mL when using spectrophotometric method, and 0.4-3.6, 1.6-8.8 µg/mL when spectrofluorimetric method was applied for propafenone HCl and diltiazem HCl, respectively. The limit of quantitation and the limit of detection were also calculated. The methods were applied successfully to commercial dosage form and can be further applied for their determination on a large scale in quality control laboratories. The obtained results statistically agreed with those obtained by reference methods. The determination of the studied drugs by the fixed concentration and rate constant methods is feasible with the calibration equations obtained, but the fixed time method proves to be more applicable.

4_1_35_43

Keywords


Diltiazem HCl; Propafenone HCl; Spectroflourimetric; Spectrophotometric; Kinetic determination; 4-Chloro-7-nitrobenzofurazan

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DOI: 10.5155/eurjchem.4.1.35-43.713

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How to cite


Ayad, M.; Abdellatef, H.; Hosny, M.; Sharaf, Y. Eur. J. Chem. 2013, 4(1), 35-43. doi:10.5155/eurjchem.4.1.35-43.713
Ayad, M.; Abdellatef, H.; Hosny, M.; Sharaf, Y. Application of 4-chloro-7-nitrobenzofurazan for the analysis of propafenone and diltiazem hydrochlorides using kinetic spectrophotometric and spectrofluorimetric methods. Eur. J. Chem. 2013, 4(1), 35-43. doi:10.5155/eurjchem.4.1.35-43.713
Ayad, M., Abdellatef, H., Hosny, M., & Sharaf, Y. (2013). Application of 4-chloro-7-nitrobenzofurazan for the analysis of propafenone and diltiazem hydrochlorides using kinetic spectrophotometric and spectrofluorimetric methods. European Journal of Chemistry, 4(1), 35-43. doi:10.5155/eurjchem.4.1.35-43.713
Ayad, Magda, Hisham Ezzat Abdellatef, Mervat Mohamed Hosny, & Yassmin Ahmed Sharaf. "Application of 4-chloro-7-nitrobenzofurazan for the analysis of propafenone and diltiazem hydrochlorides using kinetic spectrophotometric and spectrofluorimetric methods." European Journal of Chemistry [Online], 4.1 (2013): 35-43. Web. 21 Sep. 2019
Ayad, Magda, Abdellatef, Hisham, Hosny, Mervat, AND Sharaf, Yassmin. "Application of 4-chloro-7-nitrobenzofurazan for the analysis of propafenone and diltiazem hydrochlorides using kinetic spectrophotometric and spectrofluorimetric methods" European Journal of Chemistry [Online], Volume 4 Number 1 (31 March 2013)

DOI Link: https://doi.org/10.5155/eurjchem.4.1.35-43.713

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