European Journal of Chemistry 2013, 4(3), 260-267. doi:10.5155/eurjchem.4.3.260-267.800

Synthesis, characterization, biological activity and equilibrium studies of cadmium(II) with 2,6-diaminopyridine and various bio-relevant ligands


Azza Abdelwahab Shoukry (1,*) , Saedah Rwede Al-Mhayawi (2)

(1) Department of Chemistry, Faculty of Science, Cairo University, 12613 Giza, Egypt
(2) Department of Chemistry, Faculty of Science for Girls, King Abdulaziz University, 50918 Jeddah, 21533 Kingdom of Saudi Arabia
(*) Corresponding Author

Received: 18 Apr 2013, Accepted: 29 May 2013, Published: 30 Sep 2013

Abstract


The complexing properties of 2,6-diaminopyridine (DAP) with cadmium(II) were investigated  via measuring pH (i.e., pH-metrically). Binary and ternary complexes of Cd(II) involving DAP and various biologically relevant ligands are investigated. The ligands used (L) were  amino acids, dicarboxylic acids, amides and DNA unit constituents. The ternary complexes are formed by simultaneous reactions. The results showed the formation of Cd(DAP)(L) complexes with amino acids and dicarboxylic acids. Amides form both Cd(DAP)(L) complex and the corresponding deprotonated amide species Cd(DAP)(LH-1). The concentration distributions of the various complex species formed in solution were also evaluated as a function of pH. The effect of dioxane as a solvent on the protonation constant of DAP and the formation constants of Cd(II)-DAP complexes were discussed. The solid complexes [Cd(DAP)L)] where L = methionine and glycine, were isolated and characterized. The isolated solid complexes have also been screened for their antimicrobial activities against some selected bacteria and fungi. The activity data show that the complexes are found to have antibacterial and antifungal activity.

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Keywords


Speciation; Effect of solvent; Bioactive ligands; Stability constant; 2,6-Diaminopyridine; Antimicrobial activity

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DOI: 10.5155/eurjchem.4.3.260-267.800

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[1]. Azza Abdelwahab Shoukry
Complex formation equilibria of imipenem with some transition metal ions. Ternary complex formation reactions involving Cu(II) with imipenem and various bio-relevant ligands
European Journal of Chemistry  4(4), 379, 2013
DOI: 10.5155/eurjchem.4.4.379-387.868
/


[2]. Azza A. Shoukry, Saedah R. Al-Mhayawi
Solution Equilibria of Binary and Ternary Complexes Involving Zinc(II) with 2,6-Diaminopyridine and Various Biologically Relevant Ligands
Journal of Solution Chemistry  44(10), 2073, 2015
DOI: 10.1007/s10953-015-0395-0
/


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How to cite


Shoukry, A.; Al-Mhayawi, S. Eur. J. Chem. 2013, 4(3), 260-267. doi:10.5155/eurjchem.4.3.260-267.800
Shoukry, A.; Al-Mhayawi, S. Synthesis, characterization, biological activity and equilibrium studies of cadmium(II) with 2,6-diaminopyridine and various bio-relevant ligands. Eur. J. Chem. 2013, 4(3), 260-267. doi:10.5155/eurjchem.4.3.260-267.800
Shoukry, A., & Al-Mhayawi, S. (2013). Synthesis, characterization, biological activity and equilibrium studies of cadmium(II) with 2,6-diaminopyridine and various bio-relevant ligands. European Journal of Chemistry, 4(3), 260-267. doi:10.5155/eurjchem.4.3.260-267.800
Shoukry, Azza, & Saedah Rwede Al-Mhayawi. "Synthesis, characterization, biological activity and equilibrium studies of cadmium(II) with 2,6-diaminopyridine and various bio-relevant ligands." European Journal of Chemistry [Online], 4.3 (2013): 260-267. Web. 23 Oct. 2019
Shoukry, Azza, AND Al-Mhayawi, Saedah. "Synthesis, characterization, biological activity and equilibrium studies of cadmium(II) with 2,6-diaminopyridine and various bio-relevant ligands" European Journal of Chemistry [Online], Volume 4 Number 3 (30 September 2013)

DOI Link: https://doi.org/10.5155/eurjchem.4.3.260-267.800

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