European Journal of Chemistry 2013, 4(2), 176-179 | doi: https://doi.org/10.5155/eurjchem.4.2.176-179.757 | Get rights and content






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Synthesis of pyrazoline derivatives from the 1,3-dipolar cycloadditions using α,β-unsaturated cyclohexanone derivatives


Nouara Ziani (1,*) , Kaddour Lamara (2) , Assia Sid (3) , Quentin Willem (4) , Benjamin Dassonneville (5) , Albert Demonceau (6)

(1) Département de Chimie, Faculté des Sciences, Université Ferhat Abbas, Sétif, 19000, Algérie
(2) Laboratory of Applied Chemistry and Materials Technology, Chemistry Institute, University Larbi Ben M’hidi of Oum El Bouaghi, Rue de Constantine, 04000, Algeria
(3) Laboratory of Applied Chemistry and Materials Technology, Chemistry Institute, University Larbi Ben M’hidi of Oum El Bouaghi, Rue de Constantine, 04000, Algeria
(4) Laboratoire de Chimie Macromoléculaire et de Catalyse Organique, Département de Chimie, Université de Liège, Sart-Tilman (B.6a), B-4000 Liège, Belgique
(5) Laboratoire de Chimie Macromoléculaire et de Catalyse Organique, Département de Chimie, Université de Liège, Sart-Tilman (B.6a), B-4000 Liège, Belgique
(6) Laboratoire de Chimie Macromoléculaire et de Catalyse Organique, Département de Chimie, Université de Liège, Sart-Tilman (B.6a), B-4000 Liège, Belgique
(*) Corresponding Author

Received: 21 Feb 2013 | Revised: 04 Apr 2013 | Accepted: 05 Apr 2013 | Published: 30 Jun 2013 | Issue Date: June 2013

Abstract


A series of 2-pyrazolines (3a-d) were obtained by reaction 1,3-dipolar cycloadditions of α,β-unsaturated cyclohexanone derivatives (2a-c) with hydrazine hydrate and 4-nitrophenylhydrazine in the presence of acetic acid and ethanol as solvents. The structures of the synthesized compounds were confirmed by spectroscopic methods; IR, 1H and 13C NMR.

4_2_176_179

Keywords


Acetic acid; Pyrazolines; Spectroscopy; Hydrazine hydrate; 1,3-Dipolar cycloadditions; α,β-Unsaturated cyclohexanone derivatives

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DOI: 10.5155/eurjchem.4.2.176-179.757

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Funding information


Laboratory of Applied Chemistry and Materials Technology, Chemistry Institute, University Larbi Ben M’hidi of Oum El Bouaghi, Rue de Constantine, 04000, Algeria.

Citations

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[1]. Nouara Ziani, Assia Sid, Albert Demonceau, Quentin Willem, Benjamin Dassonneville, Kaddour Lamara
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[3]. Arumugam Jayalakshmi, Nagarajan Keerthika, Santhanagopal Ramkumar
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[4]. Beena Varghese, Saleh N. Al-Busafi, FakhrEldin O. Suliman, Salma M. Z. Al-Kindy
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DOI: 10.1039/C7RA08939B
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[5]. Elena Yu. Schmidt, Elena V. Ivanova, Inna V. Tatarinova, Igor A. Ushakov, Nadezhda I. Protsuk, Boris A. Trofimov
Base-catalyzed addition of ketones to alkynes as a springboard to cycloalka[c]pyrazoline-2-carbaldehydes
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[6]. Ali Amoozadeh, Elham Tabrizian, Mehdi Salehi, Maciej Kubicki, Salman Rahmani, Taiebeh Shamsi, Mehrnoosh Bitaraf
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[7]. Maysoon Mohammed Almahdi, Ahmed Elsadig Mohammed Saeed, Nadia Hanafy Metwally
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How to cite


Ziani, N.; Lamara, K.; Sid, A.; Willem, Q.; Dassonneville, B.; Demonceau, A. Eur. J. Chem. 2013, 4(2), 176-179. doi:10.5155/eurjchem.4.2.176-179.757
Ziani, N.; Lamara, K.; Sid, A.; Willem, Q.; Dassonneville, B.; Demonceau, A. Synthesis of pyrazoline derivatives from the 1,3-dipolar cycloadditions using α,β-unsaturated cyclohexanone derivatives. Eur. J. Chem. 2013, 4(2), 176-179. doi:10.5155/eurjchem.4.2.176-179.757
Ziani, N., Lamara, K., Sid, A., Willem, Q., Dassonneville, B., & Demonceau, A. (2013). Synthesis of pyrazoline derivatives from the 1,3-dipolar cycloadditions using α,β-unsaturated cyclohexanone derivatives. European Journal of Chemistry, 4(2), 176-179. doi:10.5155/eurjchem.4.2.176-179.757
Ziani, Nouara, Kaddour Lamara, Assia Sid, Quentin Willem, Benjamin Dassonneville, & Albert Demonceau. "Synthesis of pyrazoline derivatives from the 1,3-dipolar cycloadditions using α,β-unsaturated cyclohexanone derivatives." European Journal of Chemistry [Online], 4.2 (2013): 176-179. Web. 30 May. 2020
Ziani, Nouara, Lamara, Kaddour, Sid, Assia, Willem, Quentin, Dassonneville, Benjamin, AND Demonceau, Albert. "Synthesis of pyrazoline derivatives from the 1,3-dipolar cycloadditions using α,β-unsaturated cyclohexanone derivatives" European Journal of Chemistry [Online], Volume 4 Number 2 (30 June 2013)

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