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Synthesis of new curcumin analogues from Claisen-Schmidt condensation
Nouara Ziani (1,*)
, Assia Sid (2) , Albert Demonceau (3) , Quentin Willem (4) , Benjamin Dassonneville (5) , Kaddour Lamara (6) (1) Département de Chimie, Faculté des Sciences, Université Ferhat Abbas, Sétif, 19000, Algérie
(2) Laboratory of Applied Chemistry and Materials Technology, Chemistry Institute, University Larbi Ben M’hidi of Oum El Bouaghi, Rue de Constantine, 04000, Algeria
(3) Laboratoire de Chimie Macromoléculaire et de Catalyse Organique, Département de Chimie, Université de Liège, Sart-Tilman (B.6a), B-4000 Liège, Belgique
(4) Laboratoire de Chimie Macromoléculaire et de Catalyse Organique, Département de Chimie, Université de Liège, Sart-Tilman (B.6a), B-4000 Liège, Belgique
(5) Laboratoire de Chimie Macromoléculaire et de Catalyse Organique, Département de Chimie, Université de Liège, Sart-Tilman (B.6a), B-4000 Liège, Belgique
(6) Laboratory of Applied Chemistry and Materials Technology, Chemistry Institute, University Larbi Ben M’hidi of Oum El Bouaghi, Rue de Constantine, 04000, Algeria
(*) Corresponding Author
Received: 21 Feb 2013 | Revised: 04 Apr 2013 | Accepted: 05 Apr 2013 | Published: 30 Jun 2013 | Issue Date: June 2013
Abstract
A series of new curcumin analogues were obtained by Claisen-Schmidt condensation of substituted benzaldehydes with cyclohexanone derivatives using the ratio of 1:2 of ketone to aldehyde in dilute ethanolic solution under base catalyzed (NaOH) conditions at room temperature in good yields. The structures of the synthesized compounds were confirmed by data of IR, 1H NMR, and 13C NMR spectra.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.4.2.146-148.756
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Laboratory of Applied Chemistry and Materials Technology, Chemistry Institute, University Larbi Ben M’hidi of Oum El Bouaghi, Rue de Constantine, 04000, Algeria
Citations
[1]. Nouara Ziani, Kaddour Lamara, Assia Sid, Quentin Willem, Benjamin Dassonneville, Albert Demonceau
Synthesis of pyrazoline derivatives from the 1,3-dipolar cycloadditions using α,β-unsaturated cyclohexanone derivatives
European Journal of Chemistry 4(2), 176, 2013
DOI: 10.5155/eurjchem.4.2.176-179.757
[2]. Amol A. Nagargoje, Satish V. Akolkar, Dnyaneshwar D. Subhedar, Mubarak H. Shaikh, Jaiprakash N. Sangshetti, Vijay M. Khedkar, Bapurao B. Shingate
Propargylated monocarbonyl curcumin analogues: synthesis, bioevaluation and molecular docking study
Medicinal Chemistry Research 29(10), 1902, 2020
DOI: 10.1007/s00044-020-02611-7
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DOI Link: https://doi.org/10.5155/eurjchem.4.2.146-148.756
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European Journal of Chemistry 2013, 4(2), 146-148 | doi: https://doi.org/10.5155/eurjchem.4.2.146-148.756 | Get rights and content
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