Synthesis, characterization and antimicrobial evaluation of 1-((5,3-diaryl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one | European Journal of Chemistry

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Published: Sep 30, 2013

DOI: https://doi.org/10.5155/eurjchem.4.3.268-271.824

Keywords:

Pyrazoles, Chalcones, Propanoic acid, Hydrazine hydrate, Antimicrobial activity, 1, 3-Dipolar cycloaddition

Section

Research Article

Issue

Vol. 4 No. 3 (2013): September 2013

Dates

Received 2013-05-08
Accepted 2013-06-09
Published 2013-09-30

Assia Sid

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Laboratory of Applied Chemistry and Materials Technology, Sciences of Material Department, Larbi Ben M’Hidi University, Oum El Bouaghi, 04000, Rue de Constantine, Algeria

Nouara Ziani

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Laboratory of Applied Chemistry and Materials Technology, Sciences of Material Department, Larbi Ben M’Hidi University, Oum El Bouaghi, 04000, Rue de Constantine, Algeria

Ouafa Demmen-Debbih

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Laboratory of Applied Chemistry and Materials Technology, Sciences of Material Department, Larbi Ben M’Hidi University, Oum El Bouaghi, 04000, Rue de Constantine, Algeria

Mahieddine Mokhtari

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Laboratory of Applied Chemistry and Materials Technology, Sciences of Material Department, Larbi Ben M’Hidi University, Oum El Bouaghi, 04000, Rue de Constantine, Algeria

Kaddour Lamara

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Laboratory of Applied Chemistry and Materials Technology, Sciences of Material Department, Larbi Ben M’Hidi University, Oum El Bouaghi, 04000, Rue de Constantine, Algeria

Abstract

1-((5,3-Diaryl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one, 6-10, have been synthesized by the reaction of chalcone derivatives, 1-5, with hydrazine hydrate in hot propanoic acid solution. All these compounds were characterized by different spectroscopic techniques (FT-IR, ¹H and ¹³C NMR) and elemental analyses. All the synthesized products were evaluated for antimicrobial activity. All the compounds exhibited significant to moderate antimicrobial activity.

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Sid, A.; Ziani, N.; Demmen-Debbih, O.; Mokhtari, M.; Lamara, K. Synthesis, Characterization and Antimicrobial Evaluation of 1-(5,3-Diaryl)-4,5-Dihydro-1H-Pyrazol-1-yl)propan-1-One. Eur. J. Chem. 2013, 4, 268-271.

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Supporting Agencies

Laboratory of Applied Chemistry and Materials Technology of the University of Oum El Bouaghi, Rue de Constantine, Algeria

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