European Journal of Chemistry 2013, 4(3), 268-271. doi:10.5155/eurjchem.4.3.268-271.824

Synthesis, characterization and antimicrobial evaluation of 1-((5,3-diaryl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one


Assia Sid (1,*) , Nouara Ziani (2) , Ouafa Demmen-Debbih (3) , Mahieddine Mokhtari (4) , Kaddour Lamara (5)

(1) Laboratory of Applied Chemistry and Materials Technology, Sciences of Material Department, Larbi Ben M’Hidi University, Oum El Bouaghi, 04000, Rue de Constantine, Algeria
(2) Laboratory of Applied Chemistry and Materials Technology, Sciences of Material Department, Larbi Ben M’Hidi University, Oum El Bouaghi, 04000, Rue de Constantine, Algeria
(3) Laboratory of Applied Chemistry and Materials Technology, Sciences of Material Department, Larbi Ben M’Hidi University, Oum El Bouaghi, 04000, Rue de Constantine, Algeria
(4) Laboratory of Applied Chemistry and Materials Technology, Sciences of Material Department, Larbi Ben M’Hidi University, Oum El Bouaghi, 04000, Rue de Constantine, Algeria
(5) Laboratory of Applied Chemistry and Materials Technology, Sciences of Material Department, Larbi Ben M’Hidi University, Oum El Bouaghi, 04000, Rue de Constantine, Algeria
(*) Corresponding Author

Received: 08 May 2013, Accepted: 09 Jun 2013, Published: 30 Sep 2013

Abstract


1-((5,3-Diaryl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one, 6-10, have been synthesized by the reaction of chalcone derivatives, 1-5, with hydrazine hydrate in hot propanoic acid solution. All these compounds were characterized by different spectroscopic techniques (FT-IR, 1H and 13C NMR) and elemental analyses. All the synthesized products were evaluated for antimicrobial activity. All the compounds exhibited significant to moderate antimicrobial activity.

4_3_268_271

Keywords


Pyrazoles; Chalcones; Propanoic acid; Hydrazine hydrate; Antimicrobial activity; 1,3-Dipolar cycloaddition

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DOI: 10.5155/eurjchem.4.3.268-271.824

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[1]. Mohammad Mahmoud Ibrahim
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[2]. Ouafa Dammene Debbih, Assia Sid, Rafika Bouchene, Sofiane Bouacida, Wissam Mazouz, Noureddine Gherraf
Two hydrazones derived from 1-aryl-3-(p-substituted phenyl)prop-2-en-1-one: synthesis, crystal structure, Hirshfeld surface analysis andin vitrobiological properties
Acta Crystallographica Section C Structural Chemistry  74(6), 703, 2018
DOI: 10.1107/S2053229618006812
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[3]. Farouq Emam Hawaiz, Awaz Jamil Hussein, Mohammed Kareem Samad
One-pot three-component synthesis of some new azo-pyrazoline derivatives
European Journal of Chemistry  5(2), 233, 2014
DOI: 10.5155/eurjchem.5.2.233-236.979
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How to cite


Sid, A.; Ziani, N.; Demmen-Debbih, O.; Mokhtari, M.; Lamara, K. Eur. J. Chem. 2013, 4(3), 268-271. doi:10.5155/eurjchem.4.3.268-271.824
Sid, A.; Ziani, N.; Demmen-Debbih, O.; Mokhtari, M.; Lamara, K. Synthesis, characterization and antimicrobial evaluation of 1-((5,3-diaryl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one. Eur. J. Chem. 2013, 4(3), 268-271. doi:10.5155/eurjchem.4.3.268-271.824
Sid, A., Ziani, N., Demmen-Debbih, O., Mokhtari, M., & Lamara, K. (2013). Synthesis, characterization and antimicrobial evaluation of 1-((5,3-diaryl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one. European Journal of Chemistry, 4(3), 268-271. doi:10.5155/eurjchem.4.3.268-271.824
Sid, Assia, Nouara Ziani, Ouafa Demmen-Debbih, Mahieddine Mokhtari, & Kaddour Lamara. "Synthesis, characterization and antimicrobial evaluation of 1-((5,3-diaryl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one." European Journal of Chemistry [Online], 4.3 (2013): 268-271. Web. 21 Oct. 2019
Sid, Assia, Ziani, Nouara, Demmen-Debbih, Ouafa, Mokhtari, Mahieddine, AND Lamara, Kaddour. "Synthesis, characterization and antimicrobial evaluation of 1-((5,3-diaryl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one" European Journal of Chemistry [Online], Volume 4 Number 3 (30 September 2013)

DOI Link: https://doi.org/10.5155/eurjchem.4.3.268-271.824

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