European Journal of Chemistry 2013, 4(3), 268-271 | doi: https://doi.org/10.5155/eurjchem.4.3.268-271.824 | Get rights and content






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Synthesis, characterization and antimicrobial evaluation of 1-((5,3-diaryl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one


Assia Sid (1,*) , Nouara Ziani (2) , Ouafa Demmen-Debbih (3) , Mahieddine Mokhtari (4) , Kaddour Lamara (5)

(1) Laboratory of Applied Chemistry and Materials Technology, Sciences of Material Department, Larbi Ben M’Hidi University, Oum El Bouaghi, 04000, Rue de Constantine, Algeria
(2) Laboratory of Applied Chemistry and Materials Technology, Sciences of Material Department, Larbi Ben M’Hidi University, Oum El Bouaghi, 04000, Rue de Constantine, Algeria
(3) Laboratory of Applied Chemistry and Materials Technology, Sciences of Material Department, Larbi Ben M’Hidi University, Oum El Bouaghi, 04000, Rue de Constantine, Algeria
(4) Laboratory of Applied Chemistry and Materials Technology, Sciences of Material Department, Larbi Ben M’Hidi University, Oum El Bouaghi, 04000, Rue de Constantine, Algeria
(5) Laboratory of Applied Chemistry and Materials Technology, Sciences of Material Department, Larbi Ben M’Hidi University, Oum El Bouaghi, 04000, Rue de Constantine, Algeria
(*) Corresponding Author

Received: 08 May 2013 | Revised: 07 Jun 2013 | Accepted: 09 Jun 2013 | Published: 30 Sep 2013 | Issue Date: September 2013

Abstract


1-((5,3-Diaryl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one, 6-10, have been synthesized by the reaction of chalcone derivatives, 1-5, with hydrazine hydrate in hot propanoic acid solution. All these compounds were characterized by different spectroscopic techniques (FT-IR, 1H and 13C NMR) and elemental analyses. All the synthesized products were evaluated for antimicrobial activity. All the compounds exhibited significant to moderate antimicrobial activity.

4_3_268_271

Keywords


Pyrazoles; Chalcones; Propanoic acid; Hydrazine hydrate; Antimicrobial activity; 1,3-Dipolar cycloaddition

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DOI: 10.5155/eurjchem.4.3.268-271.824

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Funding information


Laboratory of Applied Chemistry and Materials Technology of the University of Oum El Bouaghi, Rue de Constantine, Algeria

Citations

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[1]. Mohammad Mahmoud Ibrahim
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[2]. Ouafa Dammene Debbih, Assia Sid, Rafika Bouchene, Sofiane Bouacida, Wissam Mazouz, Noureddine Gherraf
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DOI: 10.1107/S2053229618006812
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[3]. Farouq Emam Hawaiz, Awaz Jamil Hussein, Mohammed Kareem Samad
One-pot three-component synthesis of some new azo-pyrazoline derivatives
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[4]. Saliha Saouli, Ilhem Selatnia, Bachir Zouchoune, Assia Sid, Saber Mustapha Zendaoui, Chawki Bensouici, El-Eulmi Bendeif
Synthesis, spectroscopic characterization, crystal structure, DFT studies and biological activities of new hydrazone derivative: 1-(2,5-bis((E)-4-isopropylbenzylidene)cyclopentylidene)-2-(2,4-dinitrophenyl) hydrazine
Journal of Molecular Structure  1213, 128203, 2020
DOI: 10.1016/j.molstruc.2020.128203
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How to cite


Sid, A.; Ziani, N.; Demmen-Debbih, O.; Mokhtari, M.; Lamara, K. Eur. J. Chem. 2013, 4(3), 268-271. doi:10.5155/eurjchem.4.3.268-271.824
Sid, A.; Ziani, N.; Demmen-Debbih, O.; Mokhtari, M.; Lamara, K. Synthesis, characterization and antimicrobial evaluation of 1-((5,3-diaryl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one. Eur. J. Chem. 2013, 4(3), 268-271. doi:10.5155/eurjchem.4.3.268-271.824
Sid, A., Ziani, N., Demmen-Debbih, O., Mokhtari, M., & Lamara, K. (2013). Synthesis, characterization and antimicrobial evaluation of 1-((5,3-diaryl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one. European Journal of Chemistry, 4(3), 268-271. doi:10.5155/eurjchem.4.3.268-271.824
Sid, Assia, Nouara Ziani, Ouafa Demmen-Debbih, Mahieddine Mokhtari, & Kaddour Lamara. "Synthesis, characterization and antimicrobial evaluation of 1-((5,3-diaryl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one." European Journal of Chemistry [Online], 4.3 (2013): 268-271. Web. 27 May. 2020
Sid, Assia, Ziani, Nouara, Demmen-Debbih, Ouafa, Mokhtari, Mahieddine, AND Lamara, Kaddour. "Synthesis, characterization and antimicrobial evaluation of 1-((5,3-diaryl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one" European Journal of Chemistry [Online], Volume 4 Number 3 (30 September 2013)

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DOI Link: https://doi.org/10.5155/eurjchem.4.3.268-271.824

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