

Synthesis, characterization and antimicrobial evaluation of 1-((5,3-diaryl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one
Assia Sid (1,*)





(1) Laboratory of Applied Chemistry and Materials Technology, Sciences of Material Department, Larbi Ben M’Hidi University, Oum El Bouaghi, 04000, Rue de Constantine, Algeria
(2) Laboratory of Applied Chemistry and Materials Technology, Sciences of Material Department, Larbi Ben M’Hidi University, Oum El Bouaghi, 04000, Rue de Constantine, Algeria
(3) Laboratory of Applied Chemistry and Materials Technology, Sciences of Material Department, Larbi Ben M’Hidi University, Oum El Bouaghi, 04000, Rue de Constantine, Algeria
(4) Laboratory of Applied Chemistry and Materials Technology, Sciences of Material Department, Larbi Ben M’Hidi University, Oum El Bouaghi, 04000, Rue de Constantine, Algeria
(5) Laboratory of Applied Chemistry and Materials Technology, Sciences of Material Department, Larbi Ben M’Hidi University, Oum El Bouaghi, 04000, Rue de Constantine, Algeria
(*) Corresponding Author
Received: 08 May 2013 | Revised: 07 Jun 2013 | Accepted: 09 Jun 2013 | Published: 30 Sep 2013 | Issue Date: September 2013
Abstract
1-((5,3-Diaryl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one, 6-10, have been synthesized by the reaction of chalcone derivatives, 1-5, with hydrazine hydrate in hot propanoic acid solution. All these compounds were characterized by different spectroscopic techniques (FT-IR, 1H and 13C NMR) and elemental analyses. All the synthesized products were evaluated for antimicrobial activity. All the compounds exhibited significant to moderate antimicrobial activity.

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DOI: 10.5155/eurjchem.4.3.268-271.824
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Laboratory of Applied Chemistry and Materials Technology of the University of Oum El Bouaghi, Rue de Constantine, Algeria
Citations
[1]. Mohammad Mahmoud Ibrahim
Synthesis and characterization of new 3,5-disubstituted-4,5-dihydro-1H-pyrazole and their carbothioamide derivatives
European Journal of Chemistry 6(1), 78, 2015
DOI: 10.5155/eurjchem.6.1.78-83.1148

[2]. Ouafa Dammene Debbih, Assia Sid, Rafika Bouchene, Sofiane Bouacida, Wissam Mazouz, Noureddine Gherraf
Two hydrazones derived from 1-aryl-3-(p-substituted phenyl)prop-2-en-1-one: synthesis, crystal structure, Hirshfeld surface analysis andin vitrobiological properties
Acta Crystallographica Section C Structural Chemistry 74(6), 703, 2018
DOI: 10.1107/S2053229618006812

[3]. Farouq Emam Hawaiz, Awaz Jamil Hussein, Mohammed Kareem Samad
One-pot three-component synthesis of some new azo-pyrazoline derivatives
European Journal of Chemistry 5(2), 233, 2014
DOI: 10.5155/eurjchem.5.2.233-236.979

[4]. Saliha Saouli, Ilhem Selatnia, Bachir Zouchoune, Assia Sid, Saber Mustapha Zendaoui, Chawki Bensouici, El-Eulmi Bendeif
Synthesis, spectroscopic characterization, crystal structure, DFT studies and biological activities of new hydrazone derivative: 1-(2,5-bis((E)-4-isopropylbenzylidene)cyclopentylidene)-2-(2,4-dinitrophenyl) hydrazine
Journal of Molecular Structure 1213, 128203, 2020
DOI: 10.1016/j.molstruc.2020.128203

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