European Journal of Chemistry

Eco-friendly UPLC method for determination of Levetiracetam and its toxic related substance



Main Article Content

Nehal Fayek Farid
Nada Sayed Abdelwahab

Abstract

Nowadays, analytical chemistry society is aware of the hazardous influence of chemicals on both health and environment. Additionally, chemists are more interested in eco-friendly methods of analysis. Levetiracetam (LEV) is an antiepileptic drug with no significant interaction with other medications and so it is a safe treatment in elderly people. The toxic pyridine-2-ol is reported in British Pharmacopoeia to be LEV impurity C (IMP-C) and related substance. A highly sensitive eco-friendly UPLC method was introduced for the first time for analysis of LEV and its toxic IMP. Separation has been carried out on CN column using 0.1% aqueous sodium lauryl sulphate:acetonitrile (7:93, v:v) with UV scanning at 205 nm. USP recommendations for method validation have been followed with respect to linearity, accuracy, robustness and ruggedness. The developed method was successfully applied for quantitation of LEV in its tablets dosage form and statistical analysis with the reported method showed no significant difference at confidence limit of 95%. The short run time (<3 minutes) and high sensitivity are of the most advantageous of developed method over the reported one.


icon graph This Abstract was viewed 1688 times | icon graph Article PDF downloaded 740 times

How to Cite
(1)
Farid, N. F.; Abdelwahab, N. S. Eco-Friendly UPLC Method for Determination of Levetiracetam and Its Toxic Related Substance. Eur. J. Chem. 2016, 7, 329-333.

Article Details

Share
Crossref - Scopus - Google - European PMC
References

[1]. The British Pharmacopoeia, Her Majesty's Stationery Office (HMSO), London, 2007.

[2]. Martindale-Extra Pharmacopoeia, 34th Ed., The Complete Drug References, The pharmaceutical Press, London, UK, 2005.

[3]. Shihabi, Z. K.; Oles, K.; Hinsdale, M. J. Chromatogr. A 2003, 1004, 9-12.
http://dx.doi.org/10.1016/S0021-9673(03)00716-7

[4]. Tunca, R.; Sozmen, M.; Citil, M.; Karapehlivan, M.; Erginsoy, S.; Yapar, K. Exp. Toxicol. Pathol. 2009, 61, 243-255.
http://dx.doi.org/10.1016/j.etp.2008.05.011

[5]. Sai-Thanuja, V.; Chandan, R. S.; Gurupadayya, B. M.; Prathyusha, W.; Indupriya M. Indo Am. J. Pharm. Res. 2014, 4, 561-565.

[6]. Santosh, V. G.; Ashwini, A. K.; Madhuri, M. K. Int. J. Pharm. Pharm. Sci. 2014, 6, 121-125.

[7]. Contin, M.; Mohamed, S.; Albani F.; Riva R.; Baruzzi A. J. Chromatogr. B 2008, 873, 129-132.
http://dx.doi.org/10.1016/j.jchromb.2008.08.007

[8]. Martens-Lobenhoffer, J.; Bode-Boger, S. M. J. Chromatogr. B 2005, 819, 197-200.
http://dx.doi.org/10.1016/j.jchromb.2005.01.040

[9]. Pucci, V.; Bugamelli, F.; Mandrioli R.; Ferranti, A.; Kenndler E.; Raggi; M. A. J. Biomed. Chromatogr. 2004, 18, 37-44.
http://dx.doi.org/10.1002/bmc.289

[10]. Jignesh, S. S.; Vidyasagar G.; Barot, H. Der Pharm. Sinica 2012, 3, 576-589.

[11]. Can, NO.; Arli, G. J. AOAC Int. 2010, 93, 1077-1085.

[12]. Ghada, M. H.; Randa, A. A.; Eman A. A. J. Liq. Chromatogr. Relat. Technol. 2013, 36, 2568-2579.

[13]. Matar, K. M. J. Pharm. Biomed. Anal. 2008, 48, 822-828.
http://dx.doi.org/10.1016/j.jpba.2008.05.035

[14]. Guo, T.; Oswald, L. M.; Mendu, D. R.; Soldin, S. J. Clinica Chimica Acta 2007, 375, 115-118.
http://dx.doi.org/10.1016/j.cca.2006.06.022

[15]. Blonk, M. I.; Van der Nagel, B. C.; Smit, L. S.; Mathot A. A. J. Chromatogr. B 2010, 878, 675-681.
http://dx.doi.org/10.1016/j.jchromb.2010.01.037

[16]. Olah, E.; Bacsoi, G.; Fekete, J.; Sharma, V. K. J. Chromatogr. Sci. 2012, 50(3), 253-258
http://dx.doi.org/10.1093/chromsci/bmr053

[17]. Dong, Y. M.; An, Q.; Lu, N. W.; Li, N. Acta Chromatog. 2015, 27, 355-372.
http://dx.doi.org/10.1556/AChrom.27.2015.2.11

[18]. Green Solvents, http://molsync.com/demo/greensolvents.php

[19]. The United States Pharmacopeia, National Formulary 35, United States Pharmacopeia Convention Inc., 30th Ed., 2012.

[20]. Farid, N. F.; Abdelwahab, N. S. Spectrochim. Acta A 2015, 145, 360-367.
http://dx.doi.org/10.1016/j.saa.2015.03.009

[21]. Abdelwahab, N. S.; Farid, N. F. RSC Adv. 2014, 4, 30523-30529.
http://dx.doi.org/10.1039/C4RA03637A

[22]. Habib, N. M.; Abdelwhab, N. S.; Abdelrahman, M. M.; Ali, N. W. Anal. Chem. Lett. 2015, 5(6), 399-409.
http://dx.doi.org/10.1080/22297928.2016.1142895

[23]. Abdelwahab, N. S.; Abdelrahman, Salama, F. M.; Ahmed, A. B. Eur. J. Chem. 2015, 6(4), 475‐481.
http://dx.doi.org/10.5155/eurjchem.6.4.475-481.1324

[24]. Morcoss, M. M.; Abdelwahab, N. S.; Ali, N. W.; Elsaady, M. T. J. Iran Chem. Soc. 2016, DOI: 10. 1007/s13738-016-0881-3

[25]. Farid, N. F.; Naguib, I. A.; Mohamed, R. S.; El‐Ghobashy, M. R. Eur. J. Chem. 2016, 7(2), 201‐205.
http://dx.doi.org/10.5155/eurjchem.7.2.201-205.1421

[26]. Nemutlu, E.; Kir, S.; Ozyuncu, O.; Beksac, M. S. Chromatographia 2007, 66, S15-S24.
http://dx.doi.org/10.1365/s10337-007-0292-9

Supporting Agencies

Sigma Pharmaceutical Industries, Quesna, Menoufia, Egypt.
Most read articles by the same author(s)

Most read articles by the same author(s)

TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).