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Eco-friendly UPLC method for determination of Levetiracetam and its toxic related substance
Nehal Fayek Farid (1,*)
, Nada Sayed Abdelwahab (2) (1) Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt
(2) Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt
(*) Corresponding Author
Received: 07 Jun 2016 | Revised: 16 Jul 2016 | Accepted: 17 Jul 2016 | Published: 30 Sep 2016 | Issue Date: September 2016
Abstract
Nowadays, analytical chemistry society is aware of the hazardous influence of chemicals on both health and environment. Additionally, chemists are more interested in eco-friendly methods of analysis. Levetiracetam (LEV) is an antiepileptic drug with no significant interaction with other medications and so it is a safe treatment in elderly people. The toxic pyridine-2-ol is reported in British Pharmacopoeia to be LEV impurity C (IMP-C) and related substance. A highly sensitive eco-friendly UPLC method was introduced for the first time for analysis of LEV and its toxic IMP. Separation has been carried out on CN column using 0.1% aqueous sodium lauryl sulphate:acetonitrile (7:93, v:v) with UV scanning at 205 nm. USP recommendations for method validation have been followed with respect to linearity, accuracy, robustness and ruggedness. The developed method was successfully applied for quantitation of LEV in its tablets dosage form and statistical analysis with the reported method showed no significant difference at confidence limit of 95%. The short run time (<3 minutes) and high sensitivity are of the most advantageous of developed method over the reported one.
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DOI: 10.5155/eurjchem.7.3.329-333.1463
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Funding information
Sigma Pharmaceutical Industries, Quesna, Menoufia, Egypt.
Citations
[1]. Noura M. Mansour, Dina.T. El-Sherbiny, Fawzia A. Ibrahim, Hussein I. El Subbagh
Validation of a specific Reversed-Phase HPLC method for the quantification of three racetams; Piracetam, Levetiracetam, and brivaracetam in the presence of Co-administered drugs in their pharmaceuticals; greenness assessment and application to biological fluid and in-vitro dissolution testing
Microchemical Journal 181, 107703, 2022
DOI: 10.1016/j.microc.2022.107703
[2]. Hazim M. Ali, Mohammed Gamal, Nada S. Abdelwahab, Nehal F. Farid
Simple GC–MS method for analysis of Levetiracetam and process-related toxic impurity
Microchemical Journal 146, 1236, 2019
DOI: 10.1016/j.microc.2019.02.063
[3]. Nada S. Abdelwahab, Nehal F. Farid, Mohamed Elagawany, Esraa H. Abdelmomen
Efficient UPLC and CE methods for the simultaneous determination of azelastine hydrochloride and its genotoxic impurity
Biomedical Chromatography 32(11), , 2018
DOI: 10.1002/bmc.4346
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DOI Link: https://doi.org/10.5155/eurjchem.7.3.329-333.1463
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European Journal of Chemistry 2016, 7(3), 329-333 | doi: https://doi.org/10.5155/eurjchem.7.3.329-333.1463 | Get rights and content
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