European Journal of Chemistry 2022, 13(4), 483-490 | doi: | Get rights and content

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Chiral metallic anticancer drugs: A brief-review

Sofi Danish Mukhtar (1) orcid , Mohammad Suhail (2,*) orcid

(1) Department of Chemistry, Government Degree College Ganderbal, Jammu & Kashmir-191201, India
(2) Department of Chemistry, Siddhartha Degree College, Aakhlaur Kheri (Saharanpur), Uttar Pradesh-251311, India
(*) Corresponding Author

Received: 20 Jul 2022 | Revised: 10 Sep 2022 | Accepted: 19 Sep 2022 | Published: 31 Dec 2022 | Issue Date: December 2022


Chiral metallic drugs are becoming the hottest point of discussion in the field of medicinal chemistry. As we know that more than 80% drugs are chiral in nature, and prescribed in the racemic form. The main problem with chiral drugs is the different biological activities of different enantiomers. This is because the human body has a chiral environment, as there is the presence of protein, carbohydrates, enzymes, and other chiral macromolecules. Hence, if a chiral anticancer drug is being prescribed to the patient in the racemic form, it means two or more drugs are being prescribed. Therefore, the chiral separation and analysis of chiral anticancer drugs are important for improving the quality of chiral drug medication. Many metal complexes are used as anticancer drugs, but the conditions become more critical if they have chirality or a chiral moiety, because of which they exist in two or more forms. Because of the presence of chirality or chiral moiety, the complex of metals is termed a chiral metallic complex. Of course, the enantioseparation of the chiral metallic complexes must be done before their prescription. Enantioseparation of the chiral metallic complex will not only provide a pharmaceutically active form to the patient but also reduce the side effects caused by the racemic mixture. Hence, the accessible article reviews the chiral metallic complexes having ruthenium, osmium, palladium, gold, silver, and platinum, etc. as central metal atoms. Besides, the future perspectives regarding the chiral metallic anticancer drugs and the role of their enantioseparation are also discussed.


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European Journal of Chemistry


Cancer; Enantiomers; Metallic drugs; Metallic complex; Enantioseparation; Chiral anticancer drugs

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DOI: 10.5155/eurjchem.13.4.483-490.2312

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How to cite

Mukhtar, S.; Suhail, M. Eur. J. Chem. 2022, 13(4), 483-490. doi:10.5155/eurjchem.13.4.483-490.2312
Mukhtar, S.; Suhail, M. Chiral metallic anticancer drugs: A brief-review. Eur. J. Chem. 2022, 13(4), 483-490. doi:10.5155/eurjchem.13.4.483-490.2312
Mukhtar, S., & Suhail, M. (2022). Chiral metallic anticancer drugs: A brief-review. European Journal of Chemistry, 13(4), 483-490. doi:10.5155/eurjchem.13.4.483-490.2312
Mukhtar, Sofi, & Mohammad Suhail. "Chiral metallic anticancer drugs: A brief-review." European Journal of Chemistry [Online], 13.4 (2022): 483-490. Web. 30 Nov. 2023
Mukhtar, Sofi, AND Suhail, Mohammad. "Chiral metallic anticancer drugs: A brief-review" European Journal of Chemistry [Online], Volume 13 Number 4 (31 December 2022)

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