European Journal of Chemistry 2011, 2(3), 311-313 | doi: | Get rights and content

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Synthesis and characterization of 1-formyl-3-phenyl-5-aryl-2-pyrazolines

Assia Sid (1,*) , Kaddour Lamara (2) , Mahieddine Mokhtari (3) , Nouara Ziani (4) , Paul Mosset (5)

(1) Laboratory of Applied Chemistry and Materials Technology, Chemistry Institute, University of Oum El Bouaghi, Rue de Constantine, 04000, Algeria
(2) Laboratory of Applied Chemistry and Materials Technology, Chemistry Institute, University of Oum El Bouaghi, Rue de Constantine, 04000, Algeria
(3) Laboratory of Applied Chemistry and Materials Technology, Chemistry Institute, University of Oum El Bouaghi, Rue de Constantine, 04000, Algeria
(4) Laboratory of Applied Chemistry and Materials Technology, Chemistry Institute, University of Oum El Bouaghi, Rue de Constantine, 04000, Algeria
(5) Université de Rennes 1, Laboratoire Sciences Chimiques de Rennes, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6226, Avenue du Général Leclerc, Rennes Cedex, 35042, France
(*) Corresponding Author

Received: 07 Mar 2011 | Revised: 18 Apr 2011 | Accepted: 29 Apr 2011 | Published: 30 Sep 2011 | Issue Date: September 2011


Reaction of chalcone derivatives 1-4 with hydrazine hydrate in presence of formic acid yielded 2-pyrazolines 5-8. Structures of these compounds have been elucidated by spectroscopic methods; IR, UV, 1H NMR, 13C NMR. Their purities were confirmed by elemental analyses.



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European Journal of Chemistry


Chalcones; Formic acid; Pyrazolines; Hydrazine hydrate; Fluorescence spectroscopy; Spectroscopy

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DOI: 10.5155/eurjchem.2.3.311-313.414

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[1]. Zhang, X. H.; Wu, S. K.; Gao, Z. Q.; Lee, C. S.; Lee, S. T.; Kwong, H. L. Thin Solid Films 2000, 371, 40-46.

[2]. Ramalingam, K.; Thyvekikakath, G. X.; Berlin, K. D.; Chesnut, R. W.; Brown, R. A.; Durham, N. N.; Ealick, S. E.; VanDerHelm, D. J. Med. Chem. 1977, 20, 847-850.

[3]. Korgaokar, S. S.; Patel, P. H.; Shah, M. J.; Parekh, H. H. Indian J. Pharm. Sci. 1996, 58, 222-225.

[4]. Rajendra, P. Y.; Lakshmana, R. A.; Prasoona, L.; Murali, K.; Ravi, K. P. Bioorg. Med. Chem. Lett. 2005, 15, 5030-5034.

[5]. Lombardino, J. G.; Otterness, I. G. J. Med. Chem. 1981, 24, 830-834.

[6]. Ozdemir, Z.; Kandilci, H. B.; Gumusel, B.; Calis, U.; Bilgin, A. A. Eur. J. Med. Chem. 2007, 42, 373-379.

[7]. Taylor, E. C.; Patel, H. H. Tetrahedron 1992, 48, 8089-8100.

[8]. Budakoti, A.; Abid, M.; Azam, A. Eur. J. Med. Chem. 2006, 41, 63-70.

[9]. Turan-Zitouni, G.; Ozdemir, A.; Guven, K. Arch. Pharm. (Weinheim) 2005, 338, 96-104.

[10]. Fathalla, O. A.; Zaki, M. E. A.; Swelam, S. A.; Nofal, S. M.; El-Eraky, W. I. Acta Pol. Pharm. 2003, 60, 51-60.

[11]. Levai, A. Monatsh. Chem. 1995, 126, 1245-1251.

[12]. Ali, M. A.; Shaharyar, M.; Siddiqui, A. A. Eur. J. Med. Chem. 2007, 42, 268-275.

[13]. Amir, M.; Kumar, H.; Khan, S. A. Bioorg. Med. Chem. Lett. 2008, 18, 918-922.

[14]. Budakoti, A.; Abid, M.; Azam, A. Eur. J. Med. Chem. 2007, 42, 544-551.

[15]. Pinto, D. C. G. A.; Silva, A. M. S.; Cavaleiro, J. A. S.; Foces-Foces, C.; Lamas-Saiz, A. L.; Jagerovic, N.; Elguero, J. Tetrahedron 1999, 55, 10187-10200.

[16]. Toth, G.; Levai, A.; Dinya, Z.; Snatzke, G. Tetrahedron 1991, 47, 8119-8132.

[17]. Kabesh, A.; Nyholm, R. S.; Mustafa, A.; Hilmy, M. K.; Julia, M.; Weedon, B. C. L.; Davis, W.; Ross, W. C. J.; Clar, E. J. Chem. Soc. 1951, 1951, 3254-3255.

[18]. Toth, G.; Szollosy, A.; Levai, A.; Kotovych, G. J. Chem. Soc. Perkin Trans. 2 1986, 1, 1895-1898.

[19]. Toth, G.; Levai, A.; Duddeck, H. Mag. Reson. Chem. 1992, 30, 235-239.

[20]. Toth, G.; Levai, A.; Szollosy, A.; Duddeck, H. Tetrahedron 1993, 49, 863-880.

[21]. Kamecki, J.; Perka, W.; Pijewska, L. Polish. J. Chem. 1985, 59, 285-292.

[22]. Pijewska, L.; Kamecki, J.; Perka-Karolczak, W. Pharmazie 1993, 48, 254-257.

[23]. Sharma, T. C.; Pawar, S. R.; Reddy, N. J. Acta Chim. Hung. 1983, 112, 159-162.

[24]. Raiford, L. C.; Peterson, W. J. J. Org. Chem. 1937, 1, 544-551.

[25]. Singh, P; Negi, J. S.; Joshi nee Pant, G.; Rawat, M. S. M.; Budakoti, A. Molbank 2009, 3, M614-M614.

[26]. Levai, A. J. Heterocyl. Chem. 1998, 35, 13-16.

How to cite

Sid, A.; Lamara, K.; Mokhtari, M.; Ziani, N.; Mosset, P. Eur. J. Chem. 2011, 2(3), 311-313. doi:10.5155/eurjchem.2.3.311-313.414
Sid, A.; Lamara, K.; Mokhtari, M.; Ziani, N.; Mosset, P. Synthesis and characterization of 1-formyl-3-phenyl-5-aryl-2-pyrazolines. Eur. J. Chem. 2011, 2(3), 311-313. doi:10.5155/eurjchem.2.3.311-313.414
Sid, A., Lamara, K., Mokhtari, M., Ziani, N., & Mosset, P. (2011). Synthesis and characterization of 1-formyl-3-phenyl-5-aryl-2-pyrazolines. European Journal of Chemistry, 2(3), 311-313. doi:10.5155/eurjchem.2.3.311-313.414
Sid, Assia, Kaddour Lamara, Mahieddine Mokhtari, Nouara Ziani, & Paul Mosset. "Synthesis and characterization of 1-formyl-3-phenyl-5-aryl-2-pyrazolines." European Journal of Chemistry [Online], 2.3 (2011): 311-313. Web. 4 Jun. 2023
Sid, Assia, Lamara, Kaddour, Mokhtari, Mahieddine, Ziani, Nouara, AND Mosset, Paul. "Synthesis and characterization of 1-formyl-3-phenyl-5-aryl-2-pyrazolines" European Journal of Chemistry [Online], Volume 2 Number 3 (30 September 2011)

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