Synthesis and antimicrobial activity of some new 1,3-thiazoles, 1,3,4-thiadiazoles, 1,2,4-triazoles and 1,3-thiazines incorporating acridine and 1,2,3,4-tetrahydroacridine moieties

Tarik El-Sayed Ali, Azza Mohammed El-Kazak

Abstract


Some new sulfur-nitrogen heterocyclic systems such as 1,3-thiazoles, 1,3,4-thiadiazoles, 1,2,4-triazoles and 1,3-thiazines incorporating acridine and 1,2,3,4-tetrahydroacridine moieties were synthesized via heterocyclization of the key intermediate 4-(acridin-9-yl)-1-(1,2,3,4-tetrahydroacridin-9-ylcarbonyl)thiosemicarbazide. Structures of the new comp-ounds were established by elemental analyses and spectral data. All the products were also screened in vitro for their antimicrobial activity.

1_1_6_11_800


Keyword(s)


Acridine; 1,2,3,4-Tetrahydroacridine; S,N-heterocycles; Antimicrobial Activity

European Journal of Chemistry, 1 (1), (2010), 6-11

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DOI: http://dx.doi.org/10.5155/eurjchem.1.1.6-11.12