European Journal of Chemistry 2018, 9(4), 400-407. doi:10.5155/eurjchem.9.4.400-407.1784

Different spectrophotometric and TLC-densitometric methods for determination of olmesartan medoxomil and hydrochlorothiazide and their degradation products


Selvia Maged Adly (1,*) orcid , Maha Mohamed Abdelrahman (2) orcid , Nada Sayed Abdelwahab (3) orcid , Nourudin Wageh Ali (4) orcid

(1) Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Alshaheed Shehata Ahmed Hegazy St., Beni-Suef 62514, Egypt
(2) Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Alshaheed Shehata Ahmed Hegazy St., Beni-Suef 62514, Egypt
(3) Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Alshaheed Shehata Ahmed Hegazy St., Beni-Suef 62514, Egypt
(4) Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Alshaheed Shehata Ahmed Hegazy St., Beni-Suef 62514, Egypt
(*) Corresponding Author

Received: 31 Aug 2018, Accepted: 10 Oct 2018, Published: 31 Dec 2018

Abstract


In this work, multivariate calibration models and TLC-densitometric methods have been developed and validated for quantitative determination of olmesartan medoxomil (OLM) and hydrochlorothiazide (HCZ) in presence of their degradation products, olmesartan (OL) and salamide (SAL), respectively. In the first method, multivariate calibration models including principal component regression (PCR) and partial least square (PLS) were applied. The wavelength range 210-343 nm was used and data was auto-scaled and mean centered as pre-processing steps for PCR and PLS models, respectively. These models were tested by application to external validation set with mean percentage recoveries 99.78, 100.01, 100.41 and 100.46% for OLM, HCZ, OL and SAL, respectively, for PLS model and also, 100.22, 100.40, 102.25 and 100.13% for them, respectively, for PCR model. The second method is TLC-densitometry at which the chromatographic separation was carried out using silica gel 60F254 TLC plates and the developing system consisted of a mixture of ethyl acetate:chloroform:methanol: formic acid:tri-ethylamine (60:40:4:4:1, by volume) with UV-scanning at 254 nm. The developed methods were successfully applied for determination of OLM and HCZ in their pharmaceutical dosage form. Also, statistical comparison was made between the developed methods and the reported method using student’s-t test and F-test and results showed that there was no significant difference between them concerning both accuracy and precision.


Keywords


Salamide; Olmesartan; TLC-densitometry; Hydrochlorthiazide; Olmesrtan medoxomil; Multivartiate calibration

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DOI: 10.5155/eurjchem.9.4.400-407.1784

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How to cite


Adly, S.; Abdelrahman, M.; Abdelwahab, N.; Ali, N. Eur. J. Chem. 2018, 9(4), 400-407. doi:10.5155/eurjchem.9.4.400-407.1784
Adly, S.; Abdelrahman, M.; Abdelwahab, N.; Ali, N. Different spectrophotometric and TLC-densitometric methods for determination of olmesartan medoxomil and hydrochlorothiazide and their degradation products. Eur. J. Chem. 2018, 9(4), 400-407. doi:10.5155/eurjchem.9.4.400-407.1784
Adly, S., Abdelrahman, M., Abdelwahab, N., & Ali, N. (2018). Different spectrophotometric and TLC-densitometric methods for determination of olmesartan medoxomil and hydrochlorothiazide and their degradation products. European Journal of Chemistry, 9(4), 400-407. doi:10.5155/eurjchem.9.4.400-407.1784
Adly, Selvia, Maha Mohamed Abdelrahman, Nada Sayed Abdelwahab, & Nourudin Wageh Ali. "Different spectrophotometric and TLC-densitometric methods for determination of olmesartan medoxomil and hydrochlorothiazide and their degradation products." European Journal of Chemistry [Online], 9.4 (2018): 400-407. Web. 26 Apr. 2019
Adly, Selvia, Abdelrahman, Maha, Abdelwahab, Nada, AND Ali, Nourudin. "Different spectrophotometric and TLC-densitometric methods for determination of olmesartan medoxomil and hydrochlorothiazide and their degradation products" European Journal of Chemistry [Online], Volume 9 Number 4 (31 December 2018)

DOI Link: https://doi.org/10.5155/eurjchem.9.4.400-407.1784

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