European Journal of Chemistry

Synthesis and X-ray crystallography of (1R,3aR,7aR)-1-((S)-1-((2R,5S)-5-(3-hydroxypentan-3-yl)tetrahydrofuran-2-yl)ethyl)-7a-methyloctahydro-4H-inden-4-one



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Modou Lo
Andrea Martínez
Hugo Santalla
Fátima Garrido
Aliou Hamady Barry
Mohamed Gaye

Abstract

The crystal of the title compound, C21H36O3 contains an oxolane ring, and six defined stereocenters which are unambigously established by the crystallography study. A three dimensional supramolecular architecture is ensured by hydrogen bonds from the hydroxy group which is both engaged in inter (O-H···O2) and intramolecular C-H···O-H) hydrogen bonds. Weak C-H···O=C hydrogen bonds are involved also into the consolidation of the network.


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Lo, M.; Martínez, A.; Santalla, H.; Garrido, F.; Barry, A. H.; Gaye, M. Synthesis and X-Ray Crystallography of (1R,3aR,7aR)-1-(S)-1-(2R,5S)-5-(3-Hydroxypentan-3-yl)tetrahydrofuran-2-yl)ethyl)-7a-Methyloctahydro-4H-Inden-4-One. Eur. J. Chem. 2017, 8, 248-251.

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References

[1]. Fernandez, C.; Santalla, H.; Garrido, F.; Gomez, G.; Fall, Y. Tetrahedron Lett. 2016, 57, 2790-2792.
https://doi.org/10.1016/j.tetlet.2016.05.045

[2]. Gandara, Z.; Perez, M.; Perez-Garcia, X.; Gomez, G.; Fall, Y. Tetrahedron Lett. 2009, 50, 4874-4877.
https://doi.org/10.1016/j.tetlet.2009.06.049

[3]. Gandara, Z.; Perez, M.; Salomon, D. G.; Ferronato, M. J.; Fermento, M. E.; Curino, A. C.; Facchinetti, M. M.; Gomez, G.; Fall, Y. Bioorg. Med. Chem. Lett. 2012, 22, 6276-6279.
https://doi.org/10.1016/j.bmcl.2012.07.095

[4]. Maehr, H.; Uskokovic, M. R.; Reddy, G. S.; Adorini, L. J. Steroid Biochem. Mol. Biol. 2004, 89-90, 35-38.
https://doi.org/10.1016/j.jsbmb.2004.03.047

[5]. Martinez, A.; Gandara, Z.; Gonzalez, M.; Gomez, G.; Fall, Y. Tetrahedron Lett. 2013, 54, 3514-3517.
https://doi.org/10.1016/j.tetlet.2013.04.098

[6]. Bruker, 2016, APEX3 (Version 2016-1-0), SADABS (Version 2014/5), SAINT (Version 8.35A). Bruker AXS Inc., Madison, Wisconsin.

[7]. Sheldrick, G. M. Acta Cryst. A 2015, 71, 3-8.
https://doi.org/10.1107/S2053273314026370

[8]. Sheldrick, G. M. Acta Cryst. C 2015, 71, 3-8.
https://doi.org/10.1107/S2053229614024218

[9]. Spek, A. L. J. Appl. Cryst. 2003, 36, 7‐13.
https://doi.org/10.1107/S0021889802022112

[10]. Martinez, A.; Santalla, H.; Garrido, F.; Barry, A. H.; Gaye, M.; Fall, Y. Acta Cryst. E 2017, 73, 115-117.
https://doi.org/10.1107/S205322961700105X

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