European Journal of Chemistry

Reactions with hydrazonoyl halides 65: Synthesis of some new 1,3,4-thiadiazoles and triazolino[4,3-a]pyrimidines containing pyrazole moiety



Main Article Content

Abdou Osman Abdelhamid
Abdelgawad Ali Fahmi
Karema Noury Mahmoud Halim

Abstract

2,3-Dihydro-1,3,4-thiadiazoles, and triazolino[4,3-a]pyrimidines containing pyrazole moieties were prepared from the reaction of alkyl 2-[1-(4-cyano-1,5-diphenyl-1H-pyrazol-3-yl)ethylidene]hydrazinecarbodithioate and pyrimidine-2-thione derivatives with appropriate hydrazonoyl halides. The structures of all the newly synthesized compounds were confirmed by elemental analyses, spectral data, and alternative route of synthesis whenever possible.

2_3_317_323_800


icon graph This Abstract was viewed 1953 times | icon graph Article PDF downloaded 839 times

How to Cite
(1)
Abdelhamid, A. O.; Fahmi, A. A.; Halim, K. N. M. Reactions With Hydrazonoyl Halides 65: Synthesis of Some New 1,3,4-Thiadiazoles and triazolino[4,3-a]pyrimidines Containing Pyrazole Moiety. Eur. J. Chem. 2011, 2, 317-323.

Article Details

Share
Crossref - Scopus - Google - European PMC
References

[1]. Trost, B. M. Chem. Rev. 1978, 78, 363-382.
http://dx.doi.org/10.1021/cr60314a002

[2]. Ganellin, R. J. Med. Chem. 1981, 24, 913-920.
http://dx.doi.org/10.1021/jm00140a001
PMid:6120235

[3]. Dogan, H. N.; Rollas, S.; Erdeniz, H. Farmaco. 1998, 53, 462-467.
http://dx.doi.org/10.1016/S0014-827X(98)00049-4

[4]. Dogan, H. N.; Duran, A.; Rollas, S.; Sener, G.; Uysal, M. K.; Gulen, D. Bioorg. Med. Chem. 2002, 10, 2893-2898.
http://dx.doi.org/10.1016/S0968-0896(02)00143-8

[5]. Palaska, E.; Sahin, G.; Kelicen, P.; Durlu, N. T.; Altinok, G. Farmaco. 2002, 57, 101-107.
http://dx.doi.org/10.1016/S0014-827X(01)01176-4

[6]. Karakus, S.; Rollas, S. Farmaco. 2002, 57, 577-581.
http://dx.doi.org/10.1016/S0014-827X(02)01252-1

[7]. Terzioglu, N.; Gursoy. A. Eur. J. Med. Chem. 2003, 38, 781-786.
http://dx.doi.org/10.1016/S0223-5234(03)00138-7

[8]. Stetter, H.; Rauscher, E. Chem. Ber. 1960, 93, 2054-2057.
http://dx.doi.org/10.1002/cber.19600930922

[9]. Ryan, A. J.; Welling, P. G.; Wright, S. E. Food. Cosmet. Toxicol. 1969, 7(4), 287-295.
http://dx.doi.org/10.1016/S0015-6264(69)80364-0

[10]. Ebnother, A.; Jucker, E.; Lindenmann, A. Helv. Chim. Acta 1959, 42, 1201-1214.
http://dx.doi.org/10.1002/hlca.19590420415

[11]. Burger, A. Medicinal Chemistry, 2nd ed. Interscience, New York, 1945, pp. 345.

[12]. Kueffner, K.; Marx, P.; Laessig, W. Ger. Offen. DE 3, 217, 877 17 Nov 1983, pp. 53. Chem. Abstr., 100, 183105p (1984).

[13]. Abolin, A. G.; Balabanov E. I.; Bespalov, B. P.; Bukin, Y. I.; Rumyantsev, B. M.; Titov, V. V.; Yudina, G. I. Zh. Nauch. Prikl. Fotogr. 1981, 26, 182-193.

[14]. Abdelhamid, A. O.; Abdelall, E. K. A.; Zaki, Y. H. J. Heterocycl. Chem. 2010, 47, 477-482.

[15]. Abdelhamid, A. O.; Afifi, M. A. M. J. Adv. Res. 2010, 1, 137-144.
http://dx.doi.org/10.1016/j.jare.2010.03.005

[16]. Abdelhamid, A. O.; Afifi, M. A. M. Synthetic Commun. 2010, 40, 1539-1550.
http://dx.doi.org/10.1080/00397910903100726

[17]. Abdelhamid, A. O.; Abdelall, E. K. A.; Abdel-Riheem, N. A.; Ahmed, S. A. Phosphorus, Sulfur, Silicon and Relat. Elem. 2010, 185, 709-718.
http://dx.doi.org/10.1080/10426500902922933

[18]. Abdelall, E. K. A.; Mohamed, M. A.; Abdelhamid, A. O. Phosphorus, Sulfur, Silicon and Relat. Elem. 2010, 185, 1862-1874.
http://dx.doi.org/10.1080/10426500903348013

[19]. Abdelhamid, A. O. J. Heterocycl. Chem. 2009, 46, 680-686.
http://dx.doi.org/10.1002/jhet.141

[20]. Abdelhamid, A. O.; Ismail, Z. H.; Abdel-Gawad, S. M.; Ghorab, M. M.; Abdel-Aziem, A. Phosphorus, Sulfur, Silicon and Relat. Elem. 2009, 184, 58-75.
http://dx.doi.org/10.1080/10426500802077630

[21]. Rupe, H. Chem. Ber. 1897, 30, 1097-1100.
http://dx.doi.org/10.1002/cber.189703001211

[22]. Abdallah, M. A. Z. Naturforsch, 2002, 57b, 699-706.

[23]. Abdelhamid, A. O.; Parkanyi, C.; Shawali, A. S.; Abdalla, M. A. J. Heterocycl. Chem. 1984, 21, 1049-1054.
http://dx.doi.org/10.1002/jhet.5570210425

[24]. Emam, H. A.; Abdelhamid, A. O. Phosphorus, Sulfur, Silicon and Relat. Elem. 1997, 131, 37-48.
http://dx.doi.org/10.1080/10426509708031594

[25]. Abdelhamid, A. O.; Emam, H. A.; Abdel-Reheem, N. A. J. Chem. Res. 1999, 532, 2323-2335.

[26]. Abdelhamid, A. O.; Abdelaziz, H. M. Phosphorus, Sulfur, Silicon and Relat. Elem. 2007, 182, 2791-2800.
http://dx.doi.org/10.1080/10426500701521548

Supporting Agencies

Most read articles by the same author(s)

Most read articles by the same author(s)

TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).