

Synthesis and anti-tumor activities of new [1,2,4]triazolo[1,5-a]pyrimidine derivatives
Sayed Abdelkader Ahmed (1)



(1) Department of Chemistry, Faculty of Science, Beni-Suef University, Beni-Suef 62514 Egypt
(2) Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt
(3) Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
(*) Corresponding Author
Received: 26 Aug 2013 | Revised: 02 Nov 2013 | Accepted: 13 Dec 2013 | Published: 30 Jun 2014 | Issue Date: June 2014
Abstract
Condensation of 1H-1,2,4-triazol-5-amine with the appropriate sodium (E)-(2-oxocycloalkylidene)methanolate gave 7,8-dihydro-6H-cyclopenta[e][1,2,4]triazolo [1,5-a]pyrimidine, 6,7,8,9-tetrahydro-[1,2,4]triazolo[1,5-a]quinazoline, 7,8,9,10-tetra hydro-6H-cyclohepta[e][1,2,4]triazolo[1,5-a]pyrimidine and 6,7,8,9,10,11-hexahydro cycloocta[e][1,2,4]triazolo[1,5-a]pyrimidine. Structures of the newly synthesized compounds were elucidated via elemental analyses, spectral (IR, 1H NMR, 13C NMR, 2D NMR), and X-ray single crystal diffraction data. These derivatives showed potent anti-tumor cytotoxic activity in vitro using different human cancer cell lines.
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DOI: 10.5155/eurjchem.5.2.334-338.910
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Citations
[1]. Sobhi Gomha, Yasser Zaki, Abdou Abdelhamid
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DOI: 10.3390/molecules201219803

[2]. Ashraf M. Mohamed, Wael A. El-Sayed, Alhussein A. Ibrahim, Naglaa A. Abdel-Hafez, Korany A. K. Ali, Salwa F. Mohamed
Recent Trends in the Chemistry of [1,2,4]Triazole[1,5-a]pyrimidines
Organic Preparations and Procedures International 53(3), 211, 2021
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[3]. Nadia A. Abdelriheem, Yasser H. Zaki, Abdou O. Abdelhamid
Synthesis of some new pyrazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine, 1,3,4-thiadiazole and pyridine derivatives containing 1,2,3-triazole moiety
Chemistry Central Journal 11(1), , 2017
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[4]. Majid Mokaber-Esfahani, Hossein Eshghi, Ali Shiri, Marzieh Akbarzadeh, Mahdi Mirzaei
Synthesis of [1,2,4]Triazolo[3,4-b]Pteridines as a Novel Class of Heterocyclic Compounds
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DOI: 10.3184/174751915X14271341601550

[5]. Nadia Abdelriheem, Sayed Ahmad, Abdou Abdelhamid
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[6]. Abdou O. Abdelhamid, Sobhi M. Gomha, Ahmad S. Shawali
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[7]. Maksym Fizer, Mikhailo Slivka
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[8]. Hassan M. Abdel-aziz, Sobhi M. Gomha, Abdelaziz A. El-Sayed, Yahia Nasser Mabkhot, Abdulrhman Alsayari, Abdullatif Bin Muhsinah
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